Tratamento de insuficiência cardíaca com benazepril em cães com cardiomiopatia dilatada e endocardiose

Pereira, Patrícia Mendes; Camacho, Aparecido Antônio; Morais, Helio Autrán de

doi:10.1590/s0102-09352005000800002

Cited by 7 publications

(6 citation statements)

References 16 publications

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“…Serum sodium and potassium revealed a decline in the animals treated with furosemide, due to increased excretion caused by the medicine (Pereira 1996). Among animals that received enalapril maleate, it was shown no significant increase of serum potassium (Waltkins et al 1976), probably due to the actions of SRAA, leading to decreased excretion of potassium, with the increase of these values in a benefic way, as reported by Ettinger et al (1998), Maranhão et al (1988) and Pereira et al (2005).…”

Section: Discussionmentioning

confidence: 85%

Clinical evaluation of enalapril maleate and furosemide usage in dogs with degenerative myxomatous mitral valve, CHF functional class Ib

Franco¹,

Pereira²,

Camacho³

2011

Pesq. Vet. Bras.

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791Pesq. Vet. Bras. 31(9):791-797, setembro 2011 RESUMO.-[Avaliação clínica da utilização do maleato de enalapril e furosemida em cães com doença degenerativa mixomatosa da válvula mitral, classe funcional Ib.] A doença degenerativa mixomatosa da válvula mitral (DDMVM) é uma cardiopatia de alta incidência na clínica médica de pequenos animais, acometendo mormente cães idosos e raças de pequeno porte. Desta forma, foi realizada uma investigação científica objetivando avaliar clinicamente a utilização dos fármacos maleato de enalapril e furosemida em cães com a referida enfermidade na classe funcional Ib da ICC, antes e após a terapêutica implantada. Para isso, utilizaram-se 16 cães portadores da valvulopatia supracitada, distribuídos em dois grupos; com o primeiro recebendo furosemida (n=8) e o segundo maleato de enalapril (n=8), durante 56 dias. Os cães foram avaliados em quatro momentos (T0, T14, T28 e T56 dias) quanto aos sinais clínicos e parâmetros hematológicos e bioquímico-séricos, que incluíram concentrações séricas da enzima conversora da angiotensina (ECA) e aldosterona, como também avaliações radiográficas, eletrocardiográficas, ecodopplercardiográficas e da pressão arterial. Os resultados quanto aos parâmetros clínicos, avaliações hematológicas e bioquímicas séricas não revelaram alterações significativas em ambos os grupos, mas reduções significativas nos valores de ECA e aldosterona no grupo que recebeu o maleato de enalapril foram identificadas. Ao exame radiográfico obser- Degenerative myxomatous mitral valve (DMMV) is a heart disease of high incidence in small animal clinical medicine, affecting mainly older dogs and small breeds. Thus, a scientific investigation was performed in order to evaluate the clinical use of the medicines furosemide and enalapril maleate in dogs with this disease in CHF functional class Ib before and after the treatment was established. For this purpose 16 dogs with the given valve disease were used, separated into two groups: the first received furosemide (n=8) and the second received enalapril maleate (n=8) throughout 56 days. The dogs were evaluated in four stages (T0, T14, T28 and T56 day) in relation to clinical signs, hematological, biochemical and serum assessment, which included serum angiotensin converting enzyme (ACE) and aldosterone, as well as radiography, electrocardiography, Doppler-echocardiography and blood pressure. The results regarding the clinical, hematological and serum chemistry evaluations revealed no significant changes in both groups, but significant reductions in the values of ACE and aldosterone in the group receiving enalapril maleate were verified. The radiographic examination revealed reductions of VHS values and variable Pms wave of the electrocardiogram in both groups, but no changes in blood pressure values were identified. The echocardiogram showed a significant decrease of the variables LVDd/ s in the studied groups and the FS% in animals that received only enalapril. Therefore, analysis of results showed that monotherapy based on e...

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Section: Discussionmentioning

confidence: 85%

Clinical evaluation of enalapril maleate and furosemide usage in dogs with degenerative myxomatous mitral valve, CHF functional class Ib

Franco¹,

Pereira²,

Camacho³

2011

Pesq. Vet. Bras.

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“…Due to these findings, drug therapy [24] was chosen with the use of an angiotensin converting enzyme (ACE) inhibitor, benazepril, at a dose of 0.5 mg / kg for the treatment of heart failure, aiming at the relaxation of the right ventricle and, consequently, improvement in the transvalvar gradient [25]. Pharmacological blockade of ACE-activated hormones or their metabolic pathways prolongs survival in patients with Congestive Heart Failure (CHF).…”

Section: Discussionmentioning

confidence: 99%

“…Such alterations are similar to echocardiographic findings in human PD patients, in which pulmonary stenosis, right ventricular hypertrophy, reduced RV systolic function, biatrial enlargement, aortic insufficiency, mitral and tricuspid insufficiency and shunts were reported. However, the severity of these varied changes in each case according to the degree of the change and the presence of other pathologies [15,23].Due to these findings, drug therapy [24] was chosen with the use of an angiotensin converting enzyme (ACE) inhibitor, benazepril, at a dose of 0.5 mg / kg for the treatment of heart failure, aiming at the relaxation of the right ventricle and, consequently, improvement in the transvalvar gradient [25]. Pharmacological blockade of ACE-activated hormones or their metabolic pathways prolongs survival in patients with Congestive Heart Failure (CHF).…”

mentioning

confidence: 99%

Canine Animal as a Model in the Repercussion of Pulmonary Stenosis: Analysis by Two-Dimensional Echocardiography and Doppler Mode - Case Report

Rodrigues

Pessoa

Moura

et al. 2017

MOJAP

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Pulmonary stenosis is a congenital disease characterized by narrowing of the right ventricular outflow tract. This change results in a resistance to blood flow and, consequently, an increase in the after load, leading to the elevation of systolic pressure of the right ventricle, resulting in concentric hypertrophy. Echocardiographic findings, such as right ventricular diastolic dysfunction, stenosis and pulmonary valve insufficiency, with regurgitant flow observed at color Doppler, were essential for diagnosis. A 5 years old small dog, attended at the Hospital Veterinário Universitário HVU / UFPI, was taken as an animal model to report the hemodynamic changes caused by pulmonary insufficiency and stenosis, in a comparative analysis to the same disease when it occurs in humans. Due to the similarities between hemodynamic findings in pulmonary stenosis of dogs and humans, this species proved to be a good animal model to evaluate the repercussion of this congenital heart disease by Doppler echocardiography IntroductionPulmonary stenosis (PE) is a heart disease characterized by a narrowing of the right ventricular outflow tract due to the occurrence of a fibrous ring, which may manifest as congenital or rarely acquired [1]. This change causes resistance to blood flow and an increase in after load, causing elevation of right ventricular systolic pressure, resulting in concentric hypertrophy. Some canine breeds are predisposed to the occurrence of this disease, Case PresentationIt was attended at the Hospital Veterinário Universitário da Universidade Federal do Piauí -HVU/UFPI a female dog, with no defined breed, 5 years old, weighing 4.5 kg. During the anamnesis, the owner reported that the animal presented fatigue, respiratory distress, tachypnea, tachycardia and lethargy. During the clinical examination, the animal was slightly dehydrated, pale mucosa, heart rate of 138 bpm, ascites and tachypnea. At the auscultation, it was identified grade IV / V systolic murmur, focusing on pulmonary valve. Clinical findings were compatible with heart disease.The animal was hospitalized and complementary exams such as, thoracic radiography, electrocardiography, echocardiography, abdominal ultrasonography, hemogram and biochemicals were requested. In the hemogram, no abnormalities were found, whereas in the biochemical, there was a decrease in urea and globulin levels and an increase in creatine kinase. Radiographic examination showed an increase in the cardiac silhouette, with loss of definition of the cardiac apex, globose heart, pleural The treatment with intravenous furosemide (1mg / kg), benazepril (0.5mg / kg) and sildenafil (1mg / kg) was started. However, the patient died five days after the consultation due to the aggravation of the case, and the guardian did not authorize the necropsy examination. DiscussionPulmonary stenosis is one of the most frequent congenital heart diseases that affect dogs, and may occur alone or in association with other conditions, although the patient in question presented pulmonary ...

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“…Em outras palavras, a ativação do simpático sobre o coração resulta em aumento da frequência cardíaca (FC) e força de contração do músculo cardíaco(ERICKSON, 2006). diminuição da síntese de óxido nítrico e inativação da bradicinina pela ECA, induzindo à uma hiperplasia, hipertrofia e apoptose das células musculares da parede dos vasos(PEREIRA et. al, 2005; TRALDI JUNIOR, 2008).Além da sua ação vasodilatadora, a bradicinina também tem ação inibitória sobre o crescimento e proliferação celular.…”

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ESTUDOS SOBRE A TOXICIDADE DA PEÇONHA DE Bothrops jararaca SOBRE Saccharomyces cerevisiae E O EFEITO DO EXTRATO HIDROALCOÓLICO DE Stryphnodendron fissuratum

Almeida¹,

Silva²,

Pereira³

et al. 2020

Inovação E Pluralidade Na Medicina Veterinária

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Todo o conteúdo deste livro está licenciado sob uma Licença de Atribuição Creative Commons. Atribuição 4.0 Internacional (CC BY 4.0).O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais.

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Tratamento de insuficiência cardíaca com benazepril em cães com cardiomiopatia dilatada e endocardiose

Cited by 7 publications

References 16 publications

Clinical evaluation of enalapril maleate and furosemide usage in dogs with degenerative myxomatous mitral valve, CHF functional class Ib

Clinical evaluation of enalapril maleate and furosemide usage in dogs with degenerative myxomatous mitral valve, CHF functional class Ib

Canine Animal as a Model in the Repercussion of Pulmonary Stenosis: Analysis by Two-Dimensional Echocardiography and Doppler Mode - Case Report

ESTUDOS SOBRE A TOXICIDADE DA PEÇONHA DE Bothrops jararaca SOBRE Saccharomyces cerevisiae E O EFEITO DO EXTRATO HIDROALCOÓLICO DE Stryphnodendron fissuratum

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