Trastornos del ánimo, psicofármacos y tiroides

L, Danilo Quiroz; K, Sergio Gloger; F, Sergio Valdivieso; Z, José Ivelic; B, Carlos Fardella

doi:10.4067/s0034-98872004001100012

Cited by 8 publications

(4 citation statements)

References 74 publications

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“…Hypothyroidism is an adverse effect associated with lithium, probably impairing thyroid hormone release, organic binding reaction and also triggering autoimmune thyroiditis [10,20]. However, the clinical and biochemical picture of our patient was compatible with a RTH, but it has not been described, as a side effect of psychiatric drugs [10].…”

Section: Case Reportmentioning

confidence: 89%

“…Biochemical analyses showed an elevation of T 3 ([800 ng/dl) and TSH suppression (\0.01 lUI/ml). It should be noted that drugs, such as lithium, among others, can affect the thyroid function [10]. Hypothyroidism is an adverse effect associated with lithium, probably impairing thyroid hormone release, organic binding reaction and also triggering autoimmune thyroiditis [10,20].…”

Section: Case Reportmentioning

confidence: 99%

“…According to this idea, it has been shown that cerebral serotonin decreases in hypothyroidism and increases in hyperthyroidism. Furthermore, this fall in intracellular serotonin levels causes a rise in thyroid releasing hormone (TRH) concentrations completing a feedback loop between thyroid and SNC [9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

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Refractory depression in a patient with peripheral resistance to thyroid hormone (RTH) and the effect of triiodothyronine treatment

Fardella

Artigas

Gloger

et al. 2007

Endocr

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We here described a 39-year-old woman with a severe chronic mood disorder, refractory to antidepressive therapy who showed a significant improvement after a self-prescription of high doses of liothyronine (T(3)). A modified Refetoff protocol was carried out to study the role of thyroid hormones on her clinical and biochemical responses. Depression severity was assessed by the HAM-D and MADRS Depression Rating Scales. Sequencing of Thyroid Receptors (TR) alpha1 and beta1 genes was done. At the final stage of the study, plasma T3 and free T3 were >800 ng/dl (80-180) and 1409 pg/dl (230-420), respectively. No changes in the cardiovascular parameters, alkaline phosphatase isoenzymes, creatinine kinase, or ferritin were observed. However, an improvement in mood was detected by specific scores (HAM-D 24 to 8; MADRS 40 to 11). No mutations in DNA- and hormone-binding-domains of TRbeta1 and TRalpha1 genes were found in proband, suggesting that the defect could be due to an unknown mutation in either the TR gene or a post receptor abnormality. These results support the existence of a peripheral RTH manifestation as a refractory chronic depression reverted by high doses of T(3). Screening for RTH in refractory chronic depression may provide an alternative treatment for this psychiatric condition.

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Section: Case Reportmentioning

confidence: 89%

Section: Case Reportmentioning

confidence: 99%

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Refractory depression in a patient with peripheral resistance to thyroid hormone (RTH) and the effect of triiodothyronine treatment

Fardella

Artigas

Gloger

et al. 2007

Endocr

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“…Existen numerosos reportes que asocian patologías tiroideas con enfermedades neuropsiquiátricas [6][7][8][9] . La principal asociación que se ha encontrado es entre el hipotiroidismo y depresión 7,9 , describiéndose en Chile una prevalencia de hipotiroidismo de 12% en pacientes consultantes en un centro de psiquiatría ambulatoria y de 23% en pacientes con depresión refractaria a tratamiento 10,11 .…”

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