Trasplante con precursores hematopoyéticos de cordón umbilical en adultos con neoplasias hematológicas en Chile: Serie clínica

P, Mauricio Burotto; C-M, Pablo Bertín; Galindo, Héctor; S, Marcelo Garrido; P, Geraldine Melgoza; N, Bruno Nervi; Ramírez, Pablo; T, Mauricio Ocqueteau; C, Pelayo Besa de; García, Vázquez; A, Verónica Jara; J, Elvira Álvarez; B, Maritsa Betancur; L, Mirtza Rivera; Z, Manuel Alvarez

doi:10.4067/s0034-98872009000800009

Cited by 2 publications

(2 citation statements)

References 22 publications

(22 reference statements)

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“…A llogeneic hematopoietic stem cell transplantation (HSCT) is a widely used therapy for the treatment of malignant and nonmalignant diseases. Since its inception, >50 000 HSCTs have been performed worldwide, including Latin America (1)(2)(3).…”

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confidence: 99%

Liver-Intestinal Involvement in Graft Versus Host Disease in Pediatric Hematopoietic Stem Cell Transplantation Patients: Ten Years of Experience in 2 Centers of Latin America

et al. 2022

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Objectives: To describe the behavior and characteristics of children with diagnosis of graft versus host disease (GVHD) with liver-intestinal involvement. Methods: Retrospective cohort study of pediatric patients with history of hematopoietic stem cell transplantation for diagnosis of GVHD with gastrointestinal (GI) or liver involvement, from 2 pediatric centers. Results: Between 2007 and 2017, 57 pediatric patients presented with liver or intestinal GVHD; 74% with GI GVHD, 11% with liver GVHD, and 15% with liver-intestinal involvement. Diarrhea (96%) and abdominal pain (55%) were the most frequent symptoms. Endoscopies were performed in 88%, and 35% required a second procedure to confirm diagnosis. Normal-appearing mucosa was observed in 17% of upper GI endoscopies and in 29% of colonoscopies. Endoscopic pathological findings were observed mainly in colon (62%). There was greater severity on colonoscopic classification in those with liver-intestinal compromise than in those with GI compromise only. Overall mortality was 26%. Conclusion: GI and liver GVHD diagnosis may present serious complications. GI involvement tends to manifest early, so it is appropriate to suspect it in the first days after transplantation, unlike liver involvement, which occurs late when other organs are involved. We did not observe a direct relationship between endoscopic and histological classification. Both GI and liver involvement in GVHD could predict greater target organ involvement.

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confidence: 99%

Liver-Intestinal Involvement in Graft Versus Host Disease in Pediatric Hematopoietic Stem Cell Transplantation Patients: Ten Years of Experience in 2 Centers of Latin America

et al. 2022

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“…Comentario. En Chile, el trasplante de sangre de cordón umbilical es una alternativa terapéutica, tanto en la población infantil como adulta, para el tratamiento de enfermedades hematológicas 3 . La inmunosupresión asociada al procedimiento es uno de los aspectos más importantes en el manejo de estos pacientes.…”

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Linfocitos T específicos contra CMV, ADV y VEB a partir de linfocitos T naive provenientes de sangre de cordón umbilical

Araos

2010

Rev. chil. infectol.

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Trasplante con precursores hematopoyéticos de cordón umbilical en adultos con neoplasias hematológicas en Chile: Serie clínica

Cited by 2 publications

References 22 publications

Liver-Intestinal Involvement in Graft Versus Host Disease in Pediatric Hematopoietic Stem Cell Transplantation Patients: Ten Years of Experience in 2 Centers of Latin America

Liver-Intestinal Involvement in Graft Versus Host Disease in Pediatric Hematopoietic Stem Cell Transplantation Patients: Ten Years of Experience in 2 Centers of Latin America

Linfocitos T específicos contra CMV, ADV y VEB a partir de linfocitos T naive provenientes de sangre de cordón umbilical

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