Trapping of ions injected from an external source into a three-dimensional quadrupole trap

Schuessler, H. A.; Chun‐Sing, O

doi:10.1016/0029-554x(81)90909-5

Cited by 21 publications

(1 citation statement)

References 16 publications

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“…It has long been recognized that ions can be injected into a quadrupole ion trap mass spectrometer (ITMS) from a remote source or from a boundary of the trap. , Interest in these methods of ion injection has recently been stimulated by advances in ITMS operation , and the introduction of effective new ionization sources for biopolymers that use matrix-assisted laser desorption/ionization (MALDI) or electrospray ionization (ESI) . The demand for high sensitivity in biological applications requires efficient interfacing of such ionization sources to the mass spectrometer and efficient detection of the trapped ions.…”

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confidence: 99%

Matrix-Assisted Laser Desorption Ion Trap Mass Spectrometry: Efficient Trapping and Ejection of Ions

Qin

Chait

1996

Anal. Chem.

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The present paper explores the coupling of a matrix-assisted laser desorption/ionization (MALDI) ion source with an ion trap mass analyzer, with particular emphasis on the development of methods for improving the efficiency of ion trapping and ejection. A technique is described for directly measuring, for the first time, the trapping efficiency of peptide ions produced in a remote external MALDI ion source. The technique was used to devise an improved scheme for trapping, which yielded efficiencies as high as 39%. An improved understanding of the resonant ejection process led us to a new resonant ejection parameter set that increased the ejection efficiency by 1 order of magnitude over more conventionally used parameter sets and allowed for marked improvements in the mass resolution of ions with m/z > 2500. The presently described improvements in the efficiencies of ion trapping and ejection together with improved methods for isolating and fragmenting ions (Qin, J.; Chait, B.T.Anal. Chem., following article in this tissue) lay the foundation for highly sensitive MALDI ion trap mass spectrometry of proteins (Qin, J.; et al. Anal. Chem. 1996, 68, 1784-1791).

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Matrix-Assisted Laser Desorption Ion Trap Mass Spectrometry: Efficient Trapping and Ejection of Ions

Qin

Chait

1996

Anal. Chem.

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A Simple Ion Source for Monoenergetic Multiply Charged Ion Beams

1985

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A b s t r a c t . A small and inexpensive electron beam ion source for multiply charged ions of noble gases is described. One of its essential characteristics is the low energy spread of the extracted ion beam, which depends on the charge state q of the ions and amounts to -q x 50 meV. The total ion current containing ionic states up to q = 6 is in the order of 10 nA. The design, construction and important parameters of the ion source are described.Eine einfachc Ionenquelle fur monoenergetische Biindcl mehrfach geladener Ionen I n h a 1 t s u b e r s i c h t. Wir beschreiben eine kleine und ohne groden Aufwand herstellbare Elek-tronenstoBquelle fur mehrfach geladene Ionen von Edelgasen. Eine ihrer hervorragendsten Eigenschaften ist die geringe Energiebreite des extrahierten Jonenbundels. Diese Energiebreite hLngt von der Ladungszahl q der Ionen ab und betragt etwa q x 50 meV. Der extrahierte Ionenstrom betragt etwa 10 nA und enthalt Ladungszustande bis zu q = 6. Funktion, Wirkungsweise und wichtige Betriebsparameter der Ionenyuelle werden beschrieben.

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Principles of Ion Traps

Werth¹

2008

Trapped Charged Particles and Fundamental Interactions

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Trapping of ions injected from an external source into a three-dimensional quadrupole trap

Cited by 21 publications

References 16 publications

Matrix-Assisted Laser Desorption Ion Trap Mass Spectrometry: Efficient Trapping and Ejection of Ions

Matrix-Assisted Laser Desorption Ion Trap Mass Spectrometry: Efficient Trapping and Ejection of Ions

A Simple Ion Source for Monoenergetic Multiply Charged Ion Beams

Principles of Ion Traps

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