Trapa japonica Pericarp Extract Reduces LPS-Induced Inflammation in Macrophages and Acute Lung Injury in Mice

Kim, Yon-Suk; Hwang, Jin-Woo; Jang, Jae‐Hyuk; Son, Sangkeun; Seo, Il-bok; Jeong, Jae-Hyun; Kim, Ee-Hwa; Moon, Sang-Ho; Jeon, Byong-Tae; Park, Pyo-Jam

doi:10.3390/molecules21030392

Cited by 29 publications

(16 citation statements)

References 28 publications

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“…have focused on their nutritional and ecological value, they have also been reported to have antioxidant, anti-cancer, and anti-diabetic effects; these were associated with a reduction in blood glucose level, and inhibition of α-amylase and α-glucosidase [ 15 ]. Trapa japonica is also used as an ethno-medicine for the treatment of gastric ulcer, diarrhea, alcohol hangover, and dysentery [ 46 ]. Trapa japonica Flerov.…”

Section: Discussionmentioning

confidence: 99%

Effects of DA-5513 on alcohol metabolism and alcoholic fatty liver in rats

Nguyen

Yong

et al. 2018

Lab Anim Res

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Hangover is characterized by a number of unpleasant physical and mental symptoms that occur after heavy alcohol drinking. In addition, consistently excessive alcohol intake is considered as a major reason causes liver disease. The present study investigated the in vivo effects of DA-5513 (Morning care® Kang Hwang) on biological parameters relevant to hangover relief and alcoholic fatty liver. Blood alcohol and acetaldehyde concentrations were determined in rats administered a single dose of alcohol and treated with DA-5513 or commercially available hangover relief beverages (Yeomyung® and Ukon®). The effects of DA-5513 on alcoholic fatty liver were also determined in rats fed alcohol-containing Lieber-DeCarli diets for 4 weeks. Serum liver function markers (aspartate and alanine aminotransferase activities) and serum/liver lipid levels were assessed. Blood alcohol and acetaldehyde concentrations were lower in the groups treated with DA-5513 or Yeomyung®, as compared with control rats. However, Ukon® did not produce any significant effects on these parameters. Treatment with DA-5513 significantly reduced serum aspartate and alanine aminotransferase activities and markedly reduced serum cholesterol and triglyceride levels, as compared with control rats. Histological observations using Oil Red O staining found that DA-5513 delayed the development of alcoholic fatty liver by reversing hepatic fat accumulation. These findings suggest that DA-5513 could have a beneficial effect on alcohol-induced hangovers and has the potential to ameliorate alcoholic fatty liver.

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Section: Discussionmentioning

confidence: 99%

Effects of DA-5513 on alcohol metabolism and alcoholic fatty liver in rats

Nguyen

Yong

et al. 2018

Lab Anim Res

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“…In order to create a ideal model for studying systemic inflammation, LPS administration has been extensively used in chicken to induce inflammatory response (Munyaka et al, 2012 ). Activation of monocytes, macrophages and various cells is the result of LPS exposure, which promotes the secretion of various pro-inflammatory mediators, containing TNF-α, IL-1β, IL-6, COX-2, and iNOS (Kim et al, 2016 ). These cytokines will promote TLR4-mediated pathways activation, which involves NF-κB (Zhai et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Baicalin Alleviates Lipopolysaccharide-Induced Liver Inflammation in Chicken by Suppressing TLR4-Mediated NF-κB Pathway

et al. 2017

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As a kind of potent stimulus, lipopolysaccharide (LPS) has the ability to cause cell damage by activating toll-like receptor(TLR)4, then nuclear factor kappa B (NF-κB) translocates into the nucleus and changes the expression of related inflammatory genes. Baicalin is extracted from Radix Scutellariae, which possesses anti-inflammation, antioxidant and antibacterial properties. However, the effects of it on LPS-induced liver inflammation have not been fully elucidated. This study aims to investigate the anti-inflammatory effects of Baicalin on the LPS-induced liver inflammation and its underlying molecular mechanisms in chicken. The results of histopathological changes, serum biochemical analysis, NO levels and myeloperoxidase activity showed that Baicalin pretreatment ameliorated LPS-induced liver inflammation. ELISA and qPCR assays showed that Baicalin dose-dependently suppressed the production of IL-1β, IL-6, and TNF-α. Furthermore, the mRNA expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) were significantly decreased by Baicalin. TLR4 is an important sensor in LPS infection. Molecular studies showed that the expression of TLR4 was inhibited by Baicalin pretreatment. In addition, Baicalin pretreatment inhibited NF-kB signaling pathway activation. All results demonstrated the protective effects of Baicalin pretreatment against LPS-induced liver inflammation in chicken via negative regulation of inflammatory mediators through the down-regulation of TLR4 expression and the inhibition of NF-kB activation.

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“…Dysregulation of inflammation causes upregulation of cytokines and adhesion expression, which is involved in numerous inflammatory disorders, including endotoxemia and sepsis ( 34 , 35 ). IL-6 and TNF-α are the two most notable pro-inflammatory cytokines secreted by macrophages, and hypersecretion of these cytokines induces widespread tissue damage in the body ( 36 , 37 ). In the present study, LPS was utilized as an agent to induce a pro-inflammatory state.…”

Section: Discussionmentioning

confidence: 99%

Bidirectional effects of moxifloxacin on the pro‑inflammatory response in lipopolysaccharide‑stimulated mouse peritoneal macrophages

Qiu

Yuan

et al. 2018

Mol Med Report

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Sepsis is a systemic inflammatory condition in response to life-threatening infections, and macrophages are a key source of inflammatory cytokines. Moxifloxacin (MXF) has antibacterial activity in Gram-positive and Gram-negative bacteria. The present study investigated the effects of MXF on a lipopolysaccharide (LPS)-stimulated inflammatory response and gene expression in macrophages. Peritoneal macrophages were isolated from male C57BL/6J mice and treated with LPS and/or MXF. The mRNA and protein expression of toll-like receptor 4 (TLR4), sphingosine kinase 1 (SPHK1) and nuclear factor (NF)-κB was determined by quantitative polymerase chain reaction, western blotting and immunofluorescence analysis. The expression of tumor necrosis factor (TNF)-α and interleukin (IL)-6 was determined with ELISAs. The data demonstrated that MXF dose-dependently decreased the viability of macrophages, and 8 and 16 µg/ml MXF prevented the LPS-induced increase in TLR4, SPHK1, NF-κB p65, TNF-α and IL-6 expression. The inhibition was most effective at a concentration of 16 µg/ml MXF, whereas, 64 µg/ml MXF exerted a pro-inflammatory effect. Collectively, the data demonstrated a bidirectional effect of MXF: Lower MXF concentrations (8 and 16 µg/ml) inhibited the inflammatory response; however, a higher MXF concentration (64 µg/ml) had a pro-inflammatory effect on LPS-treated mouse peritoneal macrophages. In conclusion, these results suggested the importance of MXF as an inhibitor of the inflammatory response at an optimal dose. MXF inhibition of the inflammatory response may be mediated by TLR4 signaling.

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Trapa japonica Pericarp Extract Reduces LPS-Induced Inflammation in Macrophages and Acute Lung Injury in Mice

Cited by 29 publications

References 28 publications

Effects of DA-5513 on alcohol metabolism and alcoholic fatty liver in rats

Effects of DA-5513 on alcohol metabolism and alcoholic fatty liver in rats

Baicalin Alleviates Lipopolysaccharide-Induced Liver Inflammation in Chicken by Suppressing TLR4-Mediated NF-κB Pathway

Bidirectional effects of moxifloxacin on the pro‑inflammatory response in lipopolysaccharide‑stimulated mouse peritoneal macrophages

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