Transurethral microwave thermotherapy: past, present and future

Rosette, Jean J.M.C.H. de la; Tubaro, Andrea; Höfner, K.; Carter, S. S. C.

doi:10.1007/bf00184118

Cited by 28 publications

(15 citation statements)

References 19 publications

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“…This study confirms previous findings regarding clinical improvement following high–energy TUMT [20, 21]. The clinically objective measured such as maximum uroflowmetry and more subjective measures such as symptom score both improve significantly from baseline following TUMT.…”

Section: Discussionsupporting

confidence: 80%

“…TUMT was performed using the Prostatron device (EDAP Technomed, Lyon, France) with the second–generation, high–energy protocol (Prostasoft 2.5) which provides a maximum power of 70 W with a rectal threshold set at 43.5°C [21]. The correct position of the treatment antenna was verified by ultrasound and the duration of treatment was 1 h. An extensive description of the treatment has been given elsewhere.…”

Section: Methodsmentioning

confidence: 99%

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A Randomized Study Comparing High–Energy TUMT to TURP: Quality–of–Life Results

Francisca

d’Ancona²,

Hendriks³

et al. 2000

European Urology

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Section: Discussionsupporting

confidence: 80%

Section: Methodsmentioning

confidence: 99%

A Randomized Study Comparing High–Energy TUMT to TURP: Quality–of–Life Results

Francisca

d’Ancona²,

Hendriks³

et al. 2000

European Urology

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“…Also, during the last decade many alternatives to prostatectomy have surfaced, ranging from the pharmacological approach to numerous procedural alternatives. [8][9][10][11][12][13] While none of these alternatives has achieved subjective and objective results comparable to those noted postoperatively, morbidity is sig nificantly decreased and one may question w hether transure thral prostatectomy-like results always m ust be obtained to achieve a good outcome. Urodynamic studies can also be useful in selection of candidates for alternative treat ments.14 '15 For the last 5 years, we performed transurethral micro wave thermotherapy in patients with lower urinary tract symptoms and BPH.…”

mentioning

confidence: 99%

Pressure-Flow Study Analyses in Patients Treated with High Energy Thermotherapy

Rosette¹,

Wildt²,

Höfner³

et al. 1996

The Journal of Urology

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Purpose: We evaluated the urodynamic changes after high energy microwave thermotherapy in patients with lower urinary tract symptoms and benign prostatic enlargement.Materials and Methods: A total of 120 patients was available for analysis with urodynamic investigation and pressure-flow studies before and 6 months after treatment. Several obstruction parameters were used to evaluate treatment outcome.Results: A significant decrease (p <0.001) in all obstruction parameters was noted. Mean detrusor pressure at maximum flow decreased from 64.7 to 39.1 cm. water, urethral resistance factor from 41,8 to 23.5 cm. water and linear passive urethral resistance relation from 3.0 to 1.4. Analysis of subgroups showed better results in patients with greater degrees of obstruction.Conclusions: High energy thermotherapy results in a significant and substantial decrease in bladder outlet obstruction.

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“…Earlier studies 18,19 already suggested the predictive value of urodynamic studies with pressure¯ow analysis and this study also con®rms the importance of this investigation when predicting outcome. Especially in predicting a poor response in the maximum¯ow parameter the pressure¯ow ®ndings are very useful.…”

Section: Discussionmentioning

confidence: 50%

High energy transurethral thermotherapy in the treatment of benign prostatic hyperplasia: criteria to predict treatment outcome

d’Ancona

Francisca

Hendriks

et al. 1999

Prostate Cancer Prostatic Dis

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In this study we analyzed the individual value of baseline parameters to predict the outcome of high energy transurethral microwave thermotherapy in the treatment of patients with lower urinary tract symptoms and benign prostatic hyperplasia.Two hundred and forty-seven patients with symptomatic benign prostatic hyperplasia were treated with high energy microwave thermotherapy using the software 2.5 (Prostatron). Mean age at the time of treatment was 66.3 (s.d. 8.2) y, the mean prostate volume 57.0 (s.d. 25.2) cc and the mean energy applied was 159 (s.d. 40) KJ. Multi variable analysis on baseline parameters was performed to evaluate their predictive value for response using the WHO-response evaluation criteria for IPSS, maximum¯ow and urodynamic obstruction (linPURR).At 1 y follow-up a 57% increase in maximum¯ow and a 59% decrease in symptom score was noticed following high energy transurethral thermotherapy. The percentage of good responders varies between 12% and 34% depending on the strati®cation (IPSS, Q max and linPURR), the percentage of intermediate responders in these categories varies between 17% and 60% and the percentage of poor responders varies between 20% and 49%. Independently predictive baseline parameters for poor response were patients' age, prostate size and grade of bladder outlet obstruction (BOO). The total amount of energy delivered during treatment is also correlated with response.For the case selection for high energy transurethral microwave thermotherapy three baseline parameters can be identi®ed which predict response for at least one response evaluation criterium: age, prostate size, grade of bladder outlet obstruction (BOO) and total amount of TUMT-energy. Especially the total amount of TUMT-energy is strongly predictive for all three response evaluation criteria, which suggests an important contribution of other mechanisms such as vascularisation and tissue composition to the outcome of high energy TUMT treatment.

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Transurethral microwave thermotherapy: past, present and future

Cited by 28 publications

References 19 publications

A Randomized Study Comparing High–Energy TUMT to TURP: Quality–of–Life Results

A Randomized Study Comparing High–Energy TUMT to TURP: Quality–of–Life Results

Pressure-Flow Study Analyses in Patients Treated with High Energy Thermotherapy

High energy transurethral thermotherapy in the treatment of benign prostatic hyperplasia: criteria to predict treatment outcome

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Transurethral microwave thermotherapy: past, present and future

Cited by 28 publications

References 19 publications

A Randomized Study Comparing High&ndash;Energy TUMT to TURP: Quality&ndash;of&ndash;Life Results

A Randomized Study Comparing High&ndash;Energy TUMT to TURP: Quality&ndash;of&ndash;Life Results

Pressure-Flow Study Analyses in Patients Treated with High Energy Thermotherapy

High energy transurethral thermotherapy in the treatment of benign prostatic hyperplasia: criteria to predict treatment outcome

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A Randomized Study Comparing High–Energy TUMT to TURP: Quality–of–Life Results

A Randomized Study Comparing High–Energy TUMT to TURP: Quality–of–Life Results