Transungual Delivery, Anti-Inflammatory Activity, and In Vivo Assessment of a Cyclodextrin Polypseudorotaxanes Nail Lacquer

Fernández-Campos, Francisco; Navarro, Francesc; Corrales, Adrián; Picas, Jordi; Pena, Eloy; González, Jordi; Otero-Espinar, Francisco J.

doi:10.3390/pharmaceutics12080730

Cited by 9 publications

(5 citation statements)

References 49 publications

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“…HP-β-CD complexation was used to improve the physical stability of thymol, a highly volatile antifungal molecule, and increase its retention in the film ( Cunha-Filho et al., 2021 ). Similar lacquers were developed in sulfur, silicon, and biotin supplements to treat nail inflammatory disorders ( Fernandez-Campos et al., 2020 ). The release of drugs is affected by the characteristics and concentration of the film former, plasticizer, solvent, and drug ( Sveikauskaite and Briedis, 2017 ; Cutrin-Gomez et al., 2018 ; Valdes et al., 2018 ; Aggarwal et al., 2020a ).…”

Section: Polymer-based Strategies In Fungal Disease Treatmentmentioning

confidence: 99%

Progress of polymer-based strategies in fungal disease management: Designed for different roles

Guo

et al. 2023

Front. Cell. Infect. Microbiol.

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Fungal diseases have posed a great challenge to global health, but have fewer solutions compared to bacterial and viral infections. Development and application of new treatment modalities for fungi are limited by their inherent essential properties as eukaryotes. The microorganism identification and drug sensitivity analyze are limited by their proliferation rates. Moreover, there are currently no vaccines for prevention. Polymer science and related interdisciplinary technologies have revolutionized the field of fungal disease management. To date, numerous advanced polymer-based systems have been developed for management of fungal diseases, including prevention, diagnosis, treatment and monitoring. In this review, we provide an overview of current needs and advances in polymer-based strategies against fungal diseases. We high light various treatment modalities. Delivery systems of antifungal drugs, systems based on polymers’ innate antifungal activities, and photodynamic therapies each follow their own mechanisms and unique design clues. We also discuss various prevention strategies including immunization and antifungal medical devices, and further describe point-of-care testing platforms as futuristic diagnostic and monitoring tools. The broad application of polymer-based strategies for both public and personal health management is prospected and integrated systems have become a promising direction. However, there is a gap between experimental studies and clinical translation. In future, well-designed in vivo trials should be conducted to reveal the underlying mechanisms and explore the efficacy as well as biosafety of polymer-based products.

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Section: Polymer-based Strategies In Fungal Disease Treatmentmentioning

confidence: 99%

Progress of polymer-based strategies in fungal disease management: Designed for different roles

Guo

et al. 2023

Front. Cell. Infect. Microbiol.

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“…Different clinical studies were carried out to demonstrate the effectiveness and biosafety of some developed nanosystems in patients with onychomycosis. Regenail ® a cyclodextrin polypseudorotaxanes nail lacquer was proven to minimize surface harshness without changing nail structure and met patient acceptance and satisfaction [70]. BB2603 is a nano-formulation of terbinafine hydrochloride and it was experimented clinically against (1%) Lamisil spray to evaluate systemic involvement, biosafety, and acceptability.…”

Section: Clinical Studies For Treating Onychomycosismentioning

confidence: 99%

Contemporary Techniques and Potential Transungual Drug Delivery Nanosystems for The Treatment of Onychomycosis

Abd-Elsalam

Abouelatta

2023

AAPS PharmSciTech

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The humanoid nail is considered an exceptional protective barrier that is formed mainly from keratin. Onychomycosis is the cause of 50% of nail infections that is generally caused by dermatophytes. Firstly, the infection was regarded as a cosmetic problem but because of the tenacious nature of onychomycosis and its relapses, these infections have attracted medical attention. The first line of therapy was the oral antifungal agents which were proven to be effective; nevertheless, they exhibited hepato-toxic side effects, alongside drug interactions. Following, the opportunity was shifted to the topical remedies, as onychomycosis is rather superficial, yet this route is hindered by the keratinized layers in the nail plate. A potential alternative to overcome the obstacle was applying different mechanical, physical, and chemical methods to boost the penetration of drugs through the nail plate. Unfortunately, these methods might be expensive, require an expert to be completed, or even be followed by pain or more serious side effects. Furthermore, topical formulations such as nail lacquers and patches do not provide enough sustaining effects. Recently, newer therapies such as nanovesicles, nanoparticles, and nanoemulsions have emerged for the treatment of onychomycosis that provided effective treatment with possibly no side effects. This review states the treatment strategies such as mechanical, physical, and chemical methods, and highlights various innovative dosage forms and nanosystems developed in the last 10 years with a focus on advanced findings regarding formulation systems. Furthermore, it demonstrates the natural bioactives and their formulation as nanosystems, and the most relevant clinical outcomes. Graphical Abstract

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“…[117] CODEN (USA): JDDTA disulfide linkages, gives it a hydrogel-like behavior, separating it from other body barriers 9 . The parts of nail assembly are hyponychium, nail matrix, nail fold, nail plate, nail bed, and onychodermal band Figure 1.…”

Section: Nail Anatomymentioning

confidence: 99%

Understanding the drug delivery through nails: a comprehensive review

Bhattacharjee

Dey

Barman

et al. 2021

J. Drug Delivery Ther.

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The nail unit is the largest cutaneous musculo-skeletal appendage. The management of nail disorders is an onerous task owing to the disease manifestations and anatomical structure of the nail plate. The topical treatment of nail infections/disorders has been a centerpiece of nail research in the past few decades as it offers a much safer and focused alternative to conventional oral therapy. However, transungual delivery had its challenges. This necessitated a lookout for novel approaches that enhanced treatment efficacy and reduced treatment time. Moreover, curing the nail condition using topical delivery has been challenging due to the lack of a validated animal model to determine the efficacy of the formulation and to establish a mathematical model that can help in predicting the desirable attributes of the formulation and permeation of various molecules through the nail plate. This review is based on publications retrieved by a selective search in PubMed. The purpose of this review is to provide an overview of nail anatomy and its disorders, factors affecting nail delivery, diagnostic procedures, current approaches, and promising approaches to treat nail infections/disorders including nail lacquers and the role of permeation enhancers, in-vitro models. This review also covers current available treatments and treatments under clinical trial. Keywords: Musculo-skeletal, Nail infection, Transungual, Mathematical model, In-vitro models.

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Transungual Delivery, Anti-Inflammatory Activity, and In Vivo Assessment of a Cyclodextrin Polypseudorotaxanes Nail Lacquer

Cited by 9 publications

References 49 publications

Progress of polymer-based strategies in fungal disease management: Designed for different roles

Progress of polymer-based strategies in fungal disease management: Designed for different roles

Contemporary Techniques and Potential Transungual Drug Delivery Nanosystems for The Treatment of Onychomycosis

Understanding the drug delivery through nails: a comprehensive review

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