Transthyretin levels: Potential biomarker for monitoring nutritional support efficacy and clinical complications risk in patients receiving parenteral nutrition

Freitas, Renata Germano Borges de Oliveira Nascimento; Hessel, Gabriel; Vasques, Ana Carolina Junqueira; Nogueira, Roberto José Negrão

doi:10.1016/j.clnesp.2017.12.012

Cited by 6 publications

(6 citation statements)

References 22 publications

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“…23,24 In this study, although the baseline CRP was high, ROC curve analysis showed that patients with less than 104 mg/L of CRP had improved prealbumin concentrations. 24 Equivalent results were obtained in a large cohort study based on 1056 critically ill trauma patients, who were divided into three groups according to calorie intake through the enteral route. 25 Serial measurements of prealbumin concentrations suggested the group with the highest calorie feed had the greatest change in prealbumin concentration between the first and the third week.…”

Section: Prealbumin As a Nutritional Markermentioning

confidence: 52%

“…23,24 This increase was not observed with other visceral proteins measured including albumin, transferrin and retinol-binding proteins. 23,24 In this study, although the baseline CRP was high, ROC curve analysis showed that patients with less than 104 mg/L of CRP had improved prealbumin concentrations. 24 Equivalent results were obtained in a large cohort study based on 1056 critically ill trauma patients, who were divided into three groups according to calorie intake through the enteral route.…”

Section: Prealbumin As a Nutritional Markermentioning

confidence: 83%

“…21 In a series of small studies in Belgium carried out on non-injured patients, prealbumin was noted to rise earlier (within days) than albumin, transferrin and retinol-binding protein, following nutrition suppplement. 22 Similarly, two studies carried out in hospital patients with unknown 23 or wide range of diagnoses 24 and receiving only parenteral nutrition showed a rapid and significant elevation of prealbumin concentrations towards normal following a marked initial depletion. 23,24 This increase was not observed with other visceral proteins measured including albumin, transferrin and retinol-binding proteins.…”

Section: Prealbumin As a Nutritional Markermentioning

confidence: 94%

“…22 Similarly, two studies carried out in hospital patients with unknown 23 or wide range of diagnoses 24 and receiving only parenteral nutrition showed a rapid and significant elevation of prealbumin concentrations towards normal following a marked initial depletion. 23,24 This increase was not observed with other visceral proteins measured including albumin, transferrin and retinol-binding proteins. 23,24 In this study, although the baseline CRP was high, ROC curve analysis showed that patients with less than 104 mg/L of CRP had improved prealbumin concentrations.…”

Section: Prealbumin As a Nutritional Markermentioning

confidence: 94%

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Prealbumin: The clinical utility and analytical methodologies

2020

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Prealbumin is a small protein which has been widely evaluated as a nutritional and a prognostic marker. The small size and concentration of prealbumin in blood proposes challenges on measuring it with high sensitivity and specificity. Over the years, a number of analytical methodologies have been developed, which may help establish prealbumin as a useful biomarker in routine clinical practice. The aim of the short review was to explore the current literature on the clinical utility of prealbumin and the advances made in the analytical methodologies of prealbumin. We searched MEDLINE, EMBASE and the Cochrane Library for articles published between January 1980 and July 2019, with the general search terms of ‘prealbumin’, ‘prognostic marker’, ‘nutritional marker’, ‘analytical methodologies’ and ‘malnutrition’. Additionally, we selected relevant articles and comprehensive overviews from reference lists of identified studies. The routine use of prealbumin in clinical practice remains debatable; however; it can complement clinical history, anthropometric assessment and physical examination to assess malnutrition with more certainty. Consensus on the clinical applications of prealbumin in the management of malnutrition is warranted.

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Section: Prealbumin As a Nutritional Markermentioning

confidence: 52%

Section: Prealbumin As a Nutritional Markermentioning

confidence: 83%

Section: Prealbumin As a Nutritional Markermentioning

confidence: 94%

Section: Prealbumin As a Nutritional Markermentioning

confidence: 94%

See 2 more Smart Citations

Prealbumin: The clinical utility and analytical methodologies

2020

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“…This process is mediated by pro-inflammatory cytokines, such as IL-6, IL-1a and TNFα (108). It has been reported that TTR functions as a biomarker for predicting poor short-term outcome and disease severity in patients with burn injuries (109,110) or respiratory failure (111), and was strongly correlated with the score of sequential organ failure assessment, and low levels of TTR were associated with an increase in mortality (112,113). Patients with low preoperative TTR levels (<0.2 g/l) are prone to increased risk of postoperative infections and need longer mechanical ventilation after heart surgery (113).…”

Section: Transferrin (Tf)mentioning

confidence: 99%

Types of acute phase reactants and their importance in vaccination (Review)

Khalil

Al-Humadi

2020

biom rep

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Vaccines are considered to be one of the most cost-effective life-saving interventions in human history. The body's inflammatory response to vaccines has both desired effects (immune response), undesired effects [(acute phase reactions (APRs)] and trade-offs. Trade-offs are more potent immune responses which may be potentially difficult to separate from potent acute phase reactions. Thus, studying acute phase proteins (APPs) during vaccination may aid our understanding of APRs and homeostatic changes which can result from inflammatory responses. Depending on the severity of the response in humans, these reactions can be classified as major, moderate or minor. In this review, types of APPs and their importance in vaccination will be discussed.

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Energy expenditure and nutrient intake after spinal cord injury: a comprehensive review and practical recommendations

et al. 2021

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Many persons with spinal cord injury (SCI) have one or more preventable chronic diseases related to excessive caloric intake, and poor eating patterns. Appropriate nutrient consumption relative to need becomes a concern despite authoritative dietary recommendations from around the world. These recommendations were developed for the nondisabled population and do not account for the injury-induced changes in body composition, hypometabolic rate, hormonal dysregulation, and nutrition status after SCI. Because evidence-based dietary reference intake values for SCI do not exist, ensuring appropriate consumption of macronutrient and micronutrients for their energy requirements becomes a challenge. In this compressive review, we briefly evaluate aspects of energy balance and appetite control relative to SCI. We report on the evidence regarding energy expenditure, nutrient intake, and their relationship after SCI. We compare this data to several established nutritional guidelines from American Heart Association, Australian Dietary Guidelines, Dietary Guidelines for Americans, Institute of Medicine Dietary Reference Intake, Public Health England Guidelines Government Dietary Recommendations, World Health Organization Healthy Diet, and the Paralyzed Veterans of America (PVA) Clinical Practice Guidelines. We also provide practical assessment and nutritional recommendations to facilitate a healthy dietary pattern after SCI. Because of a lack of strong SCI research, there are currently limited dietary recommendations outside of the PVA guidelines that capture the unique nutrient needs after SCI. Future multicenter clinical trials are needed to develop comprehensive, evidence-based dietary reference values specific for persons with SCI across the care continuum that rely on accurate, individual assessment of energy need.

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Transthyretin levels: Potential biomarker for monitoring nutritional support efficacy and clinical complications risk in patients receiving parenteral nutrition

Cited by 6 publications

References 22 publications

Prealbumin: The clinical utility and analytical methodologies

Prealbumin: The clinical utility and analytical methodologies

Types of acute phase reactants and their importance in vaccination (Review)

Energy expenditure and nutrient intake after spinal cord injury: a comprehensive review and practical recommendations

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