Transthoracic application of electrical cardiopulmonary resuscitation for treatment of cardiac arrest

Abstract

Optimal skeletal-based and cardiac-based electrical cardiopulmonary resuscitation pulse train parameters generated levels of coronary perfusion pressure significantly greater than ventricular fibrillation and comparable with manual chest compression over a short interval of untreated cardiac arrest.

Coronary Blood Flow Produced by Muscle Contractions Induced by Intracardiac Electrical CPR during Ventricular Fibrillation

“…Previously reported mean CPP for MCC at 30 seconds of VF was 22.9 ± 9.4 mmHg (n = 15) 1 . The successful skeletal‐based and cardiac‐based IC‐ECPR protocols compared favorably with MCC (P = 0.35 and P = 0.08, respectively).…”

“…Using the same experimental protocol in our laboratory, MCC was previously applied to several porcine models of VF, in a study that compared MCC with externally applied ECPR, using external defibrillation electrodes 1 . The IC‐ECPR data derived from this study were compared with these earlier MCC data.…”

“…It has recently been reported that transthoracically applied trains of electrical pulses, called electrical cardiopulmonary resuscitation (ECPR), generated coronary perfusion pressures (CPP) similar to manual chest compressions (MCC) 1 . Neuromuscular electrical stimulation principles and research served, in part, as a model for the development of ECPR pulse train characteristics 2,3 .…”