Medium voltage therapy for preventing and treating asystole and PEA in ICDs

Gilman, Byron L.; Brewer, James E.; Kroll, Kai; Kroll, Mark W.

doi:10.1109/iembs.2009.5332679

Cited by 4 publications

(5 citation statements)

References 12 publications

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“…Two different pulse train protocols have been tested: a very short pulse width of 0.15 milliseconds delivered at 14 pulses per train and a long pulse width of 7.5 milliseconds at 7 pulses per train to induce thoracic (skeletal) and myocardial muscle contractions. 48 In a large-animal model of VF, both skeletal-based and cardiac-based medium-voltage electric therapy significantly increased the coronary perfusion pressure compared with control, which was comparable to that generated by manual chest compression. Among different stimulation parameters, increasing the pulse train width from 50 to 200 milliseconds and the train rate from 60 to 120 trains per minute further improved the efficacy of medium-voltage electric therapy.…”

Section: Medium-voltage Electric Therapy For Peamentioning

confidence: 83%

Future of Implantable Devices for Cardiac Rhythm Management

2014

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Section: Medium-voltage Electric Therapy For Peamentioning

confidence: 83%

Future of Implantable Devices for Cardiac Rhythm Management

2014

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“…Chest compression and epinephrine are effective for PEA, whereas electrical defibrillation is not. Medium voltage therapy (MVT) has recently been attempted, where electrical stimulation by a cardiac device during ventricular fibrillation or PEA induces skeletal muscle contractions and maintains coronary blood flow in the same manner as chest compression [14,15]. Although this technique has not yet been put to practical use, it would appear to be well suited to cases such as the present one.…”

Section: Discussionmentioning

confidence: 99%

A case of variant angina treated with a pacemaker for cardiopulmonary arrest due to complete atrioventricular block and pulseless electrical activity

Kamishima

Yamada

Kawarai

et al. 2013

Journal of Arrhythmia

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a b s t r a c tA 55-year-old woman with variant angina was hospitalized for cardiopulmonary arrest because of pulseless electrical activity (PEA). Despite intensive postresuscitation drug therapy, another episode of angina occurred, with complete atrioventricular block and PEA. There was no confirmed ventricular fibrillation or ventricular tachycardia. Coronary arteriography did not show significant stenosis, and acetylcholine-loading test was positive. The patient was diagnosed with coronary spastic angina, and a pacemaker was implanted to stabilize hemodynamics during attacks. The pacemaker settings required some ingenuity: a high output was selected to avert pacing failure, and a rate drop response setting was selected to ensure efficient pacing.

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“…However, chest compression devices are controversial and may cause visceral damage (40). Other emerging solutions include electrical stimulation to activate chest wall muscles (41), and simplified methods for cardiopulmonary bypass or extracorporeal circulation.…”

Section: Respondmentioning

confidence: 99%

New Concepts in Sudden Cardiac Arrest to Address an Intractable Epidemic

Narayan

Wang

Daubert

2019

Journal of the American College of Cardiology

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Sudden cardiac arrest (SCA) is one of the largest causes of mortality globally, with an out-of-hospital survival below 10 % despite intense research. This document outlines challenges in addressing the epidemic of SCA, along the framework of Respond, Understand and Predict, and Prevent. Response could be improved by technology-assisted orchestration of community responder systems, access to AEDs, and innovations to match resuscitation resources to victims in place and time. Efforts to understand and predict SCA may be enhanced by refining taxonomy along phenotypical and pathophysiological ‘axes of risk’, extending beyond cardiovascular pathology to identify less heterogeneous cohorts, facilitated by open-data platforms and analytics including machine learning to integrate discoveries across disciplines. Prevention of SCA must integrate these concepts, recognizing that all members of society are stakeholders. Ultimately, solutions to the public health challenge of SCA will require greater awareness, societal debate and focused public policy.

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Medium voltage therapy for preventing and treating asystole and PEA in ICDs

Abstract: The inclusion of MVT technology in implantable devices may be effective in preparing the heart for successful defibrillation or in improving the metabolic condition of the heart to the extent that a pulsatile rhythm may spontaneously develop.

Cited by 4 publications

References 12 publications

Future of Implantable Devices for Cardiac Rhythm Management

Future of Implantable Devices for Cardiac Rhythm Management

A case of variant angina treated with a pacemaker for cardiopulmonary arrest due to complete atrioventricular block and pulseless electrical activity

New Concepts in Sudden Cardiac Arrest to Address an Intractable Epidemic

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