1998
DOI: 10.1001/archopht.116.2.157
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Transpupillary Thermotherapy

Abstract: To evaluate the efficacy and safety of transpupillary thermotherapy in treating choroidal melanoma. Methods and Patients: To perform transpupillary thermotherapy, infrared diode laser energy at 810 nm was used with a beam diameter of about 3 mm and 1-minute exposure time. All 50 patients had choroidal melanoma. We performed transpupillary thermotherapy in 21 tumors that had responded insufficiently to 800 Gy ruthenium 106 brachytherapy; it was combined with 800 Gy 106 Ru brachytherapy for 10 tumors greater tha… Show more

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Cited by 111 publications
(9 citation statements)
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References 46 publications
(73 reference statements)
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“…Tumor necrosis is induced by direct cell destruction. Although originally developed as an adjunct to plaque brachytherapy (BT),25 interest in TTT as a primary therapy grew based on the assumption that it may provide improved visual outcomes as compared with plaque radiotherapy. However, longer follow-up of initial studies using TTT as primary treatment for small posterior tumors revealed a high risk of local recurrence: 10% at 3 years, increasing to 33% at 10 years 2628.…”
Section: Treatment Of the Primary Tumormentioning
confidence: 99%
See 1 more Smart Citation
“…Tumor necrosis is induced by direct cell destruction. Although originally developed as an adjunct to plaque brachytherapy (BT),25 interest in TTT as a primary therapy grew based on the assumption that it may provide improved visual outcomes as compared with plaque radiotherapy. However, longer follow-up of initial studies using TTT as primary treatment for small posterior tumors revealed a high risk of local recurrence: 10% at 3 years, increasing to 33% at 10 years 2628.…”
Section: Treatment Of the Primary Tumormentioning
confidence: 99%
“…Thus, current evidence limits TTT to use as an adjunct to plaque BT. Several studies of combined TTT and BT have been published to date;25,30,31 however, they consist of varying treatment regimes with regard to the timing of TTT and the use of various isotopes. Most recently, the largest retrospective comparative study to date of 133 patients treated either with BT + TTT (n = 63) or with BT alone (n = 70) revealed there to be significant benefits from simultaneous TTT + BT.…”
Section: Treatment Of the Primary Tumormentioning
confidence: 99%
“…Similarly, small choroidal melanomas may be treated with argon or krypton laser photocoagulation. There are some publications concerning the application of diode laser radiation with wavelength 0.810 µm for treatment of intraocular tumors [3][4][5]. Unfortunately there are many cases of failure, of unwanted adverse effects and the application of the lasers for tumor treatment is often limited by these ones.…”
Section: Introductionmentioning
confidence: 99%
“…Oosterhuis u. Mitarb. haben flber eine Serie von insgesamt 50 mit TTT behandelten Patienten berichtet [13]. Eine Gruppe wurde wegen unzureichender Tumorregression nach Brachytherapie (Ru106) nachbehandeit.…”
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