Transpulmonary dilution-derived extravascular lung water as a measure of lung edema

Abstract

The thermodilution-derived extravascular lung water is a useful adjunct to assess lung vascular injury, cardiogenic edema and overhydration and to guide treatment in critically ill patients. The effects on morbidity and mortality of this approach need to be studied further.

An inhaled tumor necrosis factor‐alpha‐derived TIP peptide improves the pulmonary function in experimental lung injury

“…Nevertheless, this study intentionally focussed on a selection of clinically available parameters to characterise acute effects of the TIP peptide. The EVLWI shows an excellent correlation to gravimetric standard methods, while a systemic overestimation in young pigs does not compromise the suitability of the EVLWI in trend monitoring . Our findings indicate an immediate decrease of the lung fluid content through the TIP peptide.…”

Predictors of pulmonary edema formation during fluid loading in the critically ill with presumed hypovolemia*

“…The cardiac index (CI), global enddiastolic volume index, and pulmonary blood volume index (PBVI) were measured and indexed for body surface area. For techniques, we refer to other studies (16,17). The EVLW was indexed for predicted body weight (18).…”

Impact of misplaced subclavian vein catheter into jugular vein on transpulmonary thermodilution measurement variables

“…MTt means the time that half of the injected cold saline has passed the thermistor, and DSt means the duration of the exponential decrease of the dilution curve (Sakka et al, 1999;Reuter et al, 2005). Cardiac output (CO), global end-diastolic volume (GEDV), intra-thoracic blood volume (ITBV), and extra-vascular lung water (EVLW) are calculated according to the three values described above: both GEDV and ITBV are the preload indicators, and EVLW is a sensitive indicator of pulmonary edema (Katzenelson et al, 2004;Michard et al, 2005;Kuzkov et al, 2006;Khan et al, 2007;Bendjelid et al, 2010;Belda et al, 2011;Eichhorn et al, 2012;Kiefer et al, 2012). The combined measurement of CO, GEDV, and EVLW could provide a synthetic platform for hemodynamic management in critically ill patients.…”