Transporte de secreções mucóides de indivíduos saudáveis e pacientes com doença pulmonar obstrutiva crónica e bronquiectasias

Afonso, Juliana Lima; Tambascio, Joana; Souza, Hugo Celso Dutra de; Jardim, José Roberto; Martínez, José Antônio Baddini; Gastaldi, Ada Clarice

doi:10.1016/j.rppneu.2013.03.002

Cited by 5 publications

(5 citation statements)

References 18 publications

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“…BC is heterogeneous in its clinical features, causes and outcomes [6]. Respiratory secretions in individuals with BC have poor transport properties, which manifest as reduced mucociliary transport, higher contact angle, dyspnoea and decreased exercise tolerance [6]. BC is an important health problem with high morbidity, mortality and associated costs [7].…”

Section: Introductionmentioning

confidence: 99%

The Efficacy of Therapeutic Respiratory Muscle Training Interventions in People with Bronchiectasis: A Systematic Review and Meta-Analysis

Martín-Valero

Jiménez-Cebrián

Moral-Muñoz

et al. 2020

JCM

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Background: Respiratory muscle dysfunction is an important health problem with high morbidity and mortality and associated costs in patients with bronchiectasis (BC). The aim of this study was to analyse the effects of therapeutic respiratory muscle training (RMT) interventions on improving sputum clearance, ventilator function, muscle strength and functional capacity in BC. Methods: Systematic review and meta-analysis were conducted following PRISMA guidelines. Two independent investigators searched using several electronic databases. The methodological quality of nine studies was assessed using the PEDro scale. Study selection/eligibility criteria: The following were included: randomised controlled trials, randomised crossover trials and pilot studies of patients with BC that used the intervention as RMT (inspiratory/expiratory) and evaluations of respiratory muscle strength (maximal expiratory pressure/maximal inspiratory pressure). This systematic review was registered in PROSPERO (CRD42017075101). Nine studies were included, five of which obtained an A recommendation grade, three with B, and one with C. Study quality was poor to good (mean PEDro Score of 6.375 out of 10). Studies had small sample sizes (8–98). Results show improvements on PImax in favour of therapeutic respiratory muscle training intervention (MD = 6.08; 95% CI = 1.38, 10.77; p < 0.01; I2 = 92%). However, high heterogeneity was identified on meta-analysis.

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Section: Introductionmentioning

confidence: 99%

The Efficacy of Therapeutic Respiratory Muscle Training Interventions in People with Bronchiectasis: A Systematic Review and Meta-Analysis

Martín-Valero

Jiménez-Cebrián

Moral-Muñoz

et al. 2020

JCM

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“…Since MCC is fundamental in lung defense, several methods have been described to evaluate it: some analyze separately the mechanical condition of the cilia (video microscopy, photometric method) 3 13 or of the mucus (contact angle measurements, displacement of mucus by simulated cough and frog palate), 14 15 16 and others evaluate the interaction between the mucus and the cilia (clearance of inhaled radiolabeled particles, saccharin transit time [STT] test). 17 18…”

Section: Introductionmentioning

confidence: 99%

Particularities and Clinical Applicability of Saccharin Transit Time Test

Rodrigues

Freire

Uzeloto

et al. 2019

Int Arch Otorhinolaryngol

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Introduction The importance of mucociliary clearance (MCC) for the respiratory system homeostasis is clear. Therefore, evaluating this defense mechanism is fundamental in scientific research and in the clinical practice of pulmonology and of associated areas. However, MCC evaluation has not been so usual due to the complexity of methods that use radiolabeled particles. Nevertheless, as an interesting alternative, there is the saccharin transit time (STT) test. This method is reproducible, simple to perform, noninvasive, does not demand high costs, and has been widely used in studies of nasal MCC. Although the STT test is widely used, there is still lack of a detailed description of its realization. Objective The present literature review aims to provide basic information related to the STT test and to present the findings of the previous studies that used this method, discussing variations in its execution, possible influences on the obtained results and limitations of the method, as well as to relate our experience with the use of STT in researches. Data Synthesis There are several factors that can alter the results obtained from STT tests, which would raise difficulties with proper interpretation and with the discussion of the results among different studies. Conclusions Saccharin transit time is a widely used method for the evaluation of nasal MCC, and therefore, the standardization related to the previous and concurrent to test orientations, and also its execution, become essential to improve its accuracy, and allow comparisons among different studies.

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“…Previous studies have demonstrated that patients with COPD presented loss and significant alterations in mucociliary clearance. 4 , 5 Afonso et al 4 found that the mucus relative velocity of ciliary transport on frog palate was greater in the healthy individuals than in the COPD and bronchiectasis groups: healthy group =1.0±0.19 seconds, COPD group =0.91±0.17 seconds, and bronchiectasis group =0.76±0.23 seconds. 4 …”

Section: Discussionmentioning

confidence: 99%

“…Mucociliary clearance is deficient in patients with COPD 4 , 5 mainly due to mucus hypersecretion, which is related to a significant decrease in forced expiratory volume in the first second and severe coughing. This situation increases the risk of hospitalization.…”

Section: Introductionmentioning

confidence: 99%

Effects of 12 weeks of aerobic training on autonomic modulation, mucociliary clearance, and aerobic parameters in patients with COPD

Leite¹,

Ramos²,

Kalva-Filho³

et al. 2015

COPD

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IntroductionPatients with chronic obstructive pulmonary disease (COPD) exhibit aerobic function, autonomic nervous system, and mucociliary clearance alterations. These parameters can be attenuated by aerobic training, which can be applied with continuous or interval efforts. However, the possible effects of aerobic training, using progressively both continuous and interval sessions (ie, linear periodization), require further investigation.AimTo analyze the effects of 12-week aerobic training using continuous and interval sessions on autonomic modulation, mucociliary clearance, and aerobic function in patients with COPD.MethodsSixteen patients with COPD were divided into an aerobic (continuous and interval) training group (AT) (n=10) and a control group (CG) (n=6). An incremental test (initial speed of 2.0 km·h−1, constant slope of 3%, and increments of 0.5 km·h−1 every 2 minutes) was performed. The training group underwent training for 4 weeks at 60% of the peak velocity reached in the incremental test (vVO2peak) (50 minutes of continuous effort), followed by 4 weeks of sessions at 75% of vVO2peak (30 minutes of continuous effort), and 4 weeks of interval training (5×3-minute effort at vVO2peak, separated by 1 minute of passive recovery). Intensities were adjusted through an incremental test performed at the end of each period.ResultsThe AT presented an increase in the high frequency index (ms2) (P=0.04), peak oxygen uptake (VO2peak) (P=0.01), vVO2peak (P=0.04), and anaerobic threshold (P=0.02). No significant changes were observed in the CG (P>0.21) group. Neither of the groups presented changes in mucociliary clearance after 12 weeks (AT: P=0.94 and CG: P=0.69).ConclusionTwelve weeks of aerobic training (continuous and interval sessions) positively influenced the autonomic modulation and aerobic parameters in patients with COPD. However, mucociliary clearance was not affected by aerobic training.

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Transporte de secreções mucóides de indivíduos saudáveis e pacientes com doença pulmonar obstrutiva crónica e bronquiectasias

Cited by 5 publications

References 18 publications

The Efficacy of Therapeutic Respiratory Muscle Training Interventions in People with Bronchiectasis: A Systematic Review and Meta-Analysis

The Efficacy of Therapeutic Respiratory Muscle Training Interventions in People with Bronchiectasis: A Systematic Review and Meta-Analysis

Particularities and Clinical Applicability of Saccharin Transit Time Test

Effects of 12 weeks of aerobic training on autonomic modulation, mucociliary clearance, and aerobic parameters in patients with COPD

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