Transportation of Organs by Air: Safety, Quality, and Sustainability Criteria

Mantecchini, Luca; Paganelli, Filippo; Morabito, Vincenzo; Ricci, A.; Peritore, D.; Trapani, Silvia; Montemurro, A.; Rizzo, Anacleto; Sordo, E. Del; Gaeta, A.; Rizzato, Lucia; Costa, Alessandro Nanni

doi:10.1016/j.transproceed.2015.12.050

Cited by 13 publications

(9 citation statements)

References 5 publications

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“…These include allowing donor registration in community locations such as the Department of Motor Vehicles, optimization of organ and medical personnel travel logistic chains, and utilization of social networks to create positive incentives for organ donation. 28 For example, in May 2012 the social media website Facebook allowed users to specify their organ donor status along with a link to the state online donor registry. Within 24 hours online organ donation registration in the US increased between 800–12,000% depending on the state.…”

Section: Donor Evaluationmentioning

confidence: 99%

Evaluation and Management of the Potential Lung Donor

Courtwright

Cantu

2017

Clinics in Chest Medicine

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SYNOPSIS The expansion of the donor lung pool has involved an evidence-driven redefinition of acceptable donors. Proceeding with transplantation with an acceptable rather than ideal donor depends on specific patient and organ-related risk factor as well as the severity of recipient illness. Although the physiological optimization of brain dead donors has not changed significantly in recent years, the use of donor management protocols has improved procurement rates. Ex vivo lung perfusion is an increasingly viable strategy to recondition lungs that would otherwise fall below the acceptable threshold for transplant. Ex vivo perfusion trials for preservation of standard donor lungs are ongoing.

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Section: Donor Evaluationmentioning

confidence: 99%

Evaluation and Management of the Potential Lung Donor

Courtwright

Cantu

2017

Clinics in Chest Medicine

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“…Cryopreservation was developed many years ago, and in the past, in vitro fertilization techniques were developed to overcome infertility for the purpose of spermatozoid and oocyte bank preservation (Makar & Toth, ). Similarly, the shortage of organs available for transplantation (Abouna, ) led to the development of cryopreservation techniques for organs (Pegg, ) and organ transport (Mantecchini et al, ). Organs are not only preserved for transplantation but also for their stem cells to be used in tissue engineering (Sheikhi, Hultenby, Niklasson, Lundqvist, & Hovatta, ).…”

Section: Introductionmentioning

confidence: 99%

“…For the majority of the studies (animal and humans), the production of cell sheets and the grafting surgery are usually performed in the same area or facility (Utheim, Utheim, Khan, & Sehic, ). The transport of cell sheets over a short distance was uncomplicated, but it becomes challenging when cell sheets must be shipped across the country (Mantecchini et al, ; Oie & Nishida, ; Shu et al, ). One solution is to preserve the CAOMECS through vitrification.…”

Section: Introductionmentioning

confidence: 99%

Vitrification and storage of oral mucosa epithelial cell sheets

Oliva

Florentino

Bardag‐Gorce

et al. 2019

J Tissue Eng Regen Med

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Shipping time and shipping delays might affect the quality of the stem cells based engineered “organs.” In our laboratory, we have developed a limbal stem cell deficient (LSCD) rabbit model. To reverse the LSCD, we cultured oral mucosal epithelial cells for 2–3 weeks and engineered cultured autologous oral mucosa epithelial cell sheets (CAOMECS), which were grafted on the LSCD cornea. The purpose of this study was to vitrify CAOMECS and to store it until the CAOMECS can be grafted onto patients. CAOMECS were vitrified in LN2 for up to 204 days. We tested two different methods of vitrification with different solutions; however, CAOMECS were only viable when they were not stored in a vitrification solution; results were only reported from this CAOMECS. On the basis of hematoxylin and eosin staining, we showed that the CAOMECS morphology was well preserved after long‐term storage in LN2. Most of the preservation solutions maintained the CAOMECS phenotype (Ki67, proliferating cell nuclear antigen (PCNA), Beta‐Catenin, ZO‐1, E‐Cadherin, CK3, CK4, CK13). The exception was the solution composed with ethylene glycol and Dimethyl sulfoxide (DMSO): this resulted in loss of DeltaN‐p63 expression. DeltaN‐p63 is an important marker for cell proliferation. The expression of proteins involved in cell–cell connection and the differentiation markers were maintained. Apoptosis was not detected in the thawed CAOMECS. We demonstrated that CAOMECS can be stored long‐term in LN2 without affecting their morphology and phenotype.

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“…When a heart becomes available at one hospital, the medical teams must quickly transport the heart to the hospital where the recipient is located [5]. Transportation of organs is mainly carried out by road-bound vehicles [6]. In large cities such as megacities, with a population of at least 10 million inhabitants [7], the high number of cars on the roads will cause traffic issues and congestion that increase the transportation time of the organ from donor to recipient hospital.…”

Section: Introductionmentioning

confidence: 99%

“…Often airborne vehicles have to be available at short notice and many people are involved in the transportation of the organ. It has been shown that multimodal transportation increases the risk and the level of uncertainty because there are many different people and vehicles involved in the transportation chain [6]. Mode of transportation must be chosen carefully when transporting an organ since the ischemia time, which is dependent on transportation time, affects the success rate of heart transplan-tation.…”

Section: Introductionmentioning

confidence: 99%

Transportation of Donated Hearts by Drone in Comparison to Road-Bound Vehicles in Mexico City

Al-Ayyad¹,

Al-Ghraibah²,

Alkhatib³

2019

TOBEJ

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Background: Organ transportation between hospitals has many challenges since the harvested organ needs to be transplanted to the recipient within an optimal time frame. It is important to transfer the organ from the donor to the recipient site quickly and professionally. Aim: The aim of this research is to investigate whether the transportation of donated hearts by drones is more efficient than transportation using road-bound vehicles. Methods: A simulation using MatLab software was performed to calculate the heart transportation time between three different hospitals in Mexico City by road-bound vehicles and by drones. This simulation was performed to demonstrate how congestion and traffic in Mexico City prevent healthy hearts from being transplanted to patients on time. The 24-hour period was divided into four 5-hour periods and these were chosen to be: Period 1 (22:00-03:00), Period 2 (04:00-09:00), Period 3 (10:00-15:00) and Period 4 (16:00-21:00). Results: The time it took to travel between the hospitals by car within each of the 5-hour periods was calculated. It was observed that, in period 2, a high volume of traffic was present causing road-bound vehicles to take a longer time to deliver hearts to hospitals. All hospitals were within reach of each other if the hearts were to be transported by drone and the delivery time by drone in all cases was less than 1.88 hours, which is the optimum time for the harvested heart to be transported without risk from the donor to the recipient. Conclusion: Using drones will increase the safety of transplants, reduce the heart transplantation waiting list and eventually, heart transplantation may be possible in different areas of the city at rush hour times.

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Transportation of Organs by Air: Safety, Quality, and Sustainability Criteria

Cited by 13 publications

References 5 publications

Evaluation and Management of the Potential Lung Donor

Evaluation and Management of the Potential Lung Donor

Vitrification and storage of oral mucosa epithelial cell sheets

Transportation of Donated Hearts by Drone in Comparison to Road-Bound Vehicles in Mexico City

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