Transport of the Lithium Ion

Gallicchio, Vincent S.

doi:10.1007/978-1-4612-3324-4_4

Cited by 5 publications

(3 citation statements)

References 35 publications

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“…Li can enter the cell via Ca channels, the conductivity of which for Li depends on the presence of Ca [ Hess et al ., ; Gallicchio , ], which means that the flux of Li is proportional to the concentrations of both Li and Ca:

F_{L i^{+}} = k {true[L i^{+} true]}_{S W} {true[C a^{2 +} true]}_{S W}

…”

Section: Resultsmentioning

confidence: 99%

Li partitioning in the benthic foraminifera Amphistegina lessonii

Langer

Sadekov

Thoms

et al. 2015

Geochem Geophys Geosyst

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The shallow water benthic foraminifer Amphistegina lessonii was grown in seawater of variable Li and Ca concentration and shell Li/Ca was determined by means of LA-ICPMS. Shell Li/Ca is positively correlated to seawater Li/Ca only when the Li concentration of seawater is changed. If the seawater Ca concentration is changed, shell Li/Ca remains constant. This indicates that Li does not compete with Ca for incorporation in the shell of A. lessonii. A recently proposed calcification model can be applied to divalent cations (e.g., Mg and Sr), which compete for binding sites of ion transporters and positions in the calcite lattice. By contrast, the transport pathway of monovalent cations such as Li is probably diffusion based (e.g., ion-channels), and monovalent cations do not compete with Ca for a position in the calcite lattice. Here we present a new model for Li partitioning into foraminiferal calcite which predicts our experimental results and should also be applicable to other alkali metals.

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F_{L i^{+}} = k {true[L i^{+} true]}_{S W} {true[C a^{2 +} true]}_{S W}

…”

Section: Resultsmentioning

confidence: 99%

Li partitioning in the benthic foraminifera Amphistegina lessonii

Langer

Sadekov

Thoms

et al. 2015

Geochem Geophys Geosyst

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“…The initial studies used red blood cells as a model system to study lithium transport in patients with BD (Tosteson 1981). Some studies indicate that the lithium inhibition of the countertransport mechanism may be significant clinically and relevant to the lithium therapeutic action (Gallicchio 1990).…”

Section: Mechanism Of Lithium Therapeutic Action In Bdmentioning

confidence: 99%

How does lithium mediate its therapeutic effects?

Patočka¹,

Šárek²

2005

JAB

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For the psychiatrist, lithium is an effective drug for both the treatment and prophylaxis of bipolar disorder. The molecular mechanisms underlying its therapeutic actions have not yet been fully explained. The effects of lithium on a number of enzymes and biological processes have been studied. Inositol monophosphatase and glycogen synthase kinase-3 (GSK-3) have been suggested as the relevant intracellular targets for lithium action. The discovery of the role of GSK-3, the Wnt signalling system, and the anti-apoptotic factor Bcl-2 has led to the suggestion that there could be a therapeutic use for lithium in neurodegenerative disorders, such as Alzheimer´s disease

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“…Numerous investigations on the transport of the lithium ion through cell membranes of erythrocytes have established five different pathways by which anion exchange and sodium-potassium co-transport control lithium uptake into the cell, whilst sodium-lithium countertransport is the main route for lithium efflux from the cell (Gallicchio 1990b, Birch 1999. The transport of lithium through other cell membranes may be different.…”

Section: 15mentioning

confidence: 99%