Transplantation of a New Biological Product in Rare Diseases, Such as Epidermolysis Bullosa: Response and Clinical Outcome

Chronic Diabetic Wounds and Their Treatment with Skin Substitutes

“…Due to their ubiquity and history of effective clinical outcomes, ADMs are frequently utilized in a variety of pathologies besides DFU, including rare skin conditions, such as epidermolysis bullosa, plastic surgery, and burn treatment, among others [59,60,99,100]. Recent studies and meta analyses have shown the effectiveness of ADMs in regard to their ability to influence the immune response by differentially modulating key growth factors and cytokines, resulting in enhanced wound closure and faster resolution [57,61,101].…”

“…Presently, acellular dermal matrices hold a great deal of promise for the treatment of hard-healing wounds, including diabetic wounds [57,[99][100][101]. Their continued usage and examination in regard to source tissue, structural composition, and preparation are of supreme importance, with these factors playing key roles in the degradation of specific collagen fibers and their ability to integrate and provide the most beneficial immunomodulatory effects.…”

Optimization of Novel Human Acellular Dermal Dressing Sterilization for Routine Use in Clinical Practice

“…Notably, wound healing is strictly regulated by complex interactions of different cell types, including immune cells, epithelial cells, endothelial cells, fibroblasts, as well as stem and progenitor cells [32][33][34][35]. Recently, our group members showed that hADMs may increase wound closure and induce epithelization in an experimental mice model of deep wounds and in epidermolysis bullosa patients [5]. Notably, it is well established that three subsequent phases of wound healing-inflammation, proliferation, and remodeling-are orchestrated by immune cells and their related inflammatory mediators [32][33][34][35].…”

“…A commonly considered and established alternative is the use of acellular dermal matrices (ADMs), which meet most clinical expectations and may serve as a dressing alone or in combination with cellular therapy [1,2]. In fact, the use of acellular dermal scaffolds as stem cell carriers represents an exciting option to improve wound closure, reepithelization, and wound remodeling [1,[3][4][5].…”

“…Currently available ADMs are manufactured from human cadaveric skin, while others are prepared from xenogeneic skin fragments. Here, we present a novel approach in which abdominoplasty skin was used for ADM preparation as a part of a novel BIOOPA dressing, which was successful for epidermolysis bullosa treatment [3,5]. We evaluate the effects of different doses of radiation sterilization by high-energy electron beams on the collagen structure, free radicals' development, and cellular immune responses to novel ADM prepared from human abdominoplasty skin (BIOOPA scaffold).…”