2014
DOI: 10.1093/ckj/sfu132
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Transplant renal artery stenosis: clinical manifestations, diagnosis and therapy

Abstract: Transplant renal artery stenosis (TRAS) is a well-recognized vascular complication after kidney transplant. It occurs most frequently in the first 6 months after kidney transplant, and is one of the major causes of graft loss and premature death in transplant recipients. Renal hypoperfusion occurring in TRAS results in activation of the renin–angiotensin–aldosterone system; patients usually present with worsening or refractory hypertension, fluid retention and often allograft dysfunction. Flash pulmonary edema… Show more

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Cited by 87 publications
(70 citation statements)
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References 71 publications
(87 reference statements)
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“…Magnetic resonance and CT angiography tests are noninvasive and are accurate diagnostic methods when TRAS is suspected, and they have unique advantages. 9 Magnetic resonance angiography does not require the use of an iodinated contrast agent; however, it tends to overestimate the severity of stenosis. Computed tomography angiography is generally preferred because of high spatial resolution, visualization of calcium, and better urographic images.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Magnetic resonance and CT angiography tests are noninvasive and are accurate diagnostic methods when TRAS is suspected, and they have unique advantages. 9 Magnetic resonance angiography does not require the use of an iodinated contrast agent; however, it tends to overestimate the severity of stenosis. Computed tomography angiography is generally preferred because of high spatial resolution, visualization of calcium, and better urographic images.…”
Section: Discussionmentioning
confidence: 99%
“…Multislice spiral CT provides a tool for examination of the transplanted renal artery. 8,9 The multislice spiral CT scanning technique and postprocessing procedures help to improve the accuracy and sensitivity of the detection of renal artery lesions. 10 However, CT angiography may require large amounts of iodinated contrast agent, 11 and the safety and diagnostic performance of this method should be further evaluated.…”
Section: Introductionmentioning
confidence: 99%
“…The reported incidence varies from 1% to 23% 1 2. Presentation most commonly occurs in the first 6 months following transplantation but may present at a later stage 1. Hypertension and fluid retention secondary to activation of the renin–angiotensin–aldosterone system are characteristic findings.…”
Section: Descriptionmentioning
confidence: 99%
“…Early diagnosis and treatment of TRAS is important for prevention of graft damage and the systemic effects of hypertension. As a consequence of the developments in interventional radiology, operations including endovascular-balloon-angioplasty and stent implantation are more commonly performed treatment modalities [4,5,6,7,8]. Herein, we report an interesting case with transplant renovascular hypertension and ascites, both problems of whom resolved with a successful intervention of renal angioplasty.…”
Section: Introductionmentioning
confidence: 96%
“…Renal artery stenosis (RAS) is defined as renal artery diameter reduction of more than 50%, and accounts for 10% of all cases of hypertension [6]. RAS leads to a critical decline in renal perfusion pressure and results in hypoperfusion in renal parenchyma, and activation of the renin-angiotensin-aldosterone system (RAAS).…”
Section: Introductionmentioning
confidence: 99%