Transplant‐associated inflammatory breast disease

First report of a fibro‐adenoma in axillary mammary tissue of a renal transplant patient taking cyclosporin

“…Regression of FAs is possible after discontinuation of CsA, 12 or switching to alternative agents, such as tacrolimus (FK) or mycophenolate 13–15 . Although both CsA and FK are calcineurim inhibitors and have similar characteristics, the adverse effects and calcineurim phosphatase inhibitory profiles are different 13–15 .…”

“…5,10,11 Regression of FAs is possible after discontinuation of CsA, 12 or switching to alternative agents, such as tacrolimus (FK) or mycophenolate. [13][14][15] Although both CsA and FK are calcineurim inhibitors and have similar characteristics, the adverse effects and calcineurim phosphatase inhibitory profiles are different. [13][14][15] The conversion of immunosuppressive drugs is recommended for those patients who have a progressive reduction in renal function or other CsA adverse-effects like FAs.…”

“…[13][14][15] Although both CsA and FK are calcineurim inhibitors and have similar characteristics, the adverse effects and calcineurim phosphatase inhibitory profiles are different. [13][14][15] The conversion of immunosuppressive drugs is recommended for those patients who have a progressive reduction in renal function or other CsA adverse-effects like FAs. [13][14][15][16] Currently, among renal transplant patients, there are no reports on the association of ectopic breast FA and CsA.…”

“…[13][14][15] The conversion of immunosuppressive drugs is recommended for those patients who have a progressive reduction in renal function or other CsA adverse-effects like FAs. [13][14][15][16] Currently, among renal transplant patients, there are no reports on the association of ectopic breast FA and CsA. This case is the first report in the medical literature.…”

“…The association of GH and FA has not been reported in the scientific literature. [3][4][5]12,14,[15][16][17][18] Our patient also did not develop GH, suggesting that the mechanism is not the same as that of FA, probably because of endocrine changes 5 and gene mutations. 17 The excisional biopsy was made because of the size, localization and differential diagnosis with malignant tumors.…”