First report of a fibro‐adenoma in axillary mammary tissue of a renal transplant patient taking cyclosporin

Yarak, Samira; Floriano, Marcos C.; Decico, J. E.; Konishi, Chiaki; Michalany, N. S.; Enokihara, Mauro Yoshiaki; Tomimori‐Yamashita, Jane

doi:10.1111/j.1365-4632.2006.02979.x

Cited by 8 publications

(10 citation statements)

References 21 publications

(57 reference statements)

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“…In renal transplant recipients, adenomas occur rarely, and the vast majority appears in nephrogenic systems (5) and are related to the use of azathioprine (6). Three cases of post-transplant HA have been reported (7)(8)(9) that were attributed to the use of cyclosporine (7). Immunosuppressive effects increase the incidence of malignancy in transplant patients (10).…”

Section: Discussion and Future Perspectivesmentioning

confidence: 99%

The Occurrence of Primary Hepatic Adenoma in Deceased Donor Renal Transplant Recipient

et al. 2014

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ARTICLE INFO ______________________________________________________________ ______________________Main findings: We reported a case of new-onset, multi-focal hepatic adenoma in an 18 year-old man with no classic risk factors occurring forty months after a renal transplant from a cadaver donor. Histopathology of the adenoma was examined and genotype and phenotype were also analyzed. Histopathologic examination of the adenoma showed no malignancy. Genotype and phenotype analysis revealed no HNF1α or β-catenin gene mutations and no inflammatory infiltration. The patient was well and disease-free postoperatively.Case hypothesis: Hepatic adenoma occurs mostly in those taking oral contraceptives or androgenic-anabolic steroids or in those with hereditary diseases. Hepatic adenoma in a renal transplant recipient is rare and has only been reported in one case with glycogen storage disease type Ia. Immunosuppressive treatment might have contributed to the development of the neoplasm. Promising future implications: Although malignant change occurs most often in β-catenin gene mutation hepatic adenoma, surgical resection of the adenoma in a patient under immunosuppressive therapy should be considered in order to avoid the possibility of malignant transformation or hemorrhagic rupture.

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Section: Discussion and Future Perspectivesmentioning

confidence: 99%

The Occurrence of Primary Hepatic Adenoma in Deceased Donor Renal Transplant Recipient

et al. 2014

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“…Yarak et al [13] and Darwish et al [16] reported cases of fi broadenoma in accessory mammary tissue in kidney transplant recipients using Cyclosporine-A. This is one of the drugs that inhibits T-cell activation via calcineurin inhibition.…”

Section: Discussionmentioning

confidence: 99%

“…Consequently, there is an in increase in prolactin blood levels, suggesting infl uence in the steroidogenic function of the ovary and thus affecting the physiological state of the breast. Its chronic use could develop malignant cutaneous tumors and benign mucocutaneous proliferative diseases (fi broadenomas, hypertrichosis, gingival hypertrophy, papillomas, sebaceous hyperplasia and epidermic cysts) [13,16].…”

Section: Discussionmentioning

confidence: 99%

“…We conducted a systematic literature review regarding case reports of fi broadenoma in axilla by searching pubmed, using the following terms: "axillary breast" and "fi broadenoma" / "ectopic breast" and "fi broadenoma" / "axilla" [and] "fi broadenoma" / "supernumerary breast" and "fi broadenoma". We included all case reports of fi broadenoma in axilla with available abstract, totalizing 10 reports (Table 1) [1,4,8,9,[11][12][13][14][15][16]. The patients' average age was 33.2 years (minimum of 21 and maximum of 58 years), and the mean lesion size was 3.5 cm.…”

Section: Discussionmentioning

confidence: 99%

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Fibroadenoma of the Axilla in A Patient With Macroprolactinoma

Lages

2011

J Med Cases

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Ectopic breast tissues may be affected by to the same physiological and pathological alterations seen in the normal breast, including fi broadenoma. We report a 30-year-old nulliparous woman who presented with a left axillary lump, for which clinical impression of axillary lymphadenopathy was made. She was receiving treatment with cabergoline due to a prolactinoma with galactorrhea for some years, but her serum prolactin levels were still high. The patient underwent surgical resection of the nodule and the histology was identical to the fi broadenomas seen in the breast. To the best of our knowledge, this is the fi rst report of fi broadenoma of the axilla in a patient with a macroprolactinoma. fi broadenoma in an ectopic breast tissue must be kept in mind in the differential diagnosis of axillary mass.

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“…The etiology of multiple fibrodenomas of the breast is not fully understood and 17% of patients may have this condition 12 . There are some reports of multiple fibroadenomas associated with the use of immunosuppressants [11][12][13] . Therefore, cyclosporine-induced fibroadenomas should be considered in the differential diagnosis of topical and ectopic breast tumors in users of this kind of medication.…”

Section: Case Reportmentioning

confidence: 99%

Multiple bilateral fibroadenoma of the breast and axillary accessory breast: case report

Conde¹,

Morais²,

Pacheco³

et al. 2017

Rev. Bras. Mastol. (Impr.)

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RESUMOApresentamos um caso raro de múltiplos fibroadenomas envolvendo as mamas e a mama acessória axilar. À luz do conhecimento atual, a conduta mais adequada é discutida. Uma mulher de 37 anos foi encaminhada ao Serviço de Mastologia em função da queixa de nódulo em mama acessória axilar direita. No exame físico, não havia nódulos palpáveis nas mamas. Observou-se mama acessória axilar bilateral com nódulo à direita e sem alterações à esquerda. Mamografia e ultrassonografia demonstraram múltiplos nódulos de mama bilateral com características benignas e um nódulo suspeito de malignidade na axila direita. A paciente submeteu-se à punção aspirativa com agulha fina guiada por ultrassonografia do maior nódulo de cada mama e do nódulo na mama acessória axilar direita. Citologicamente, todos os nódulos apresentaram características benignas. Formulou-se a hipótese diagnóstica Trabalho realizado no Serviço de Mastologia, Hospital Materno Infantil -Goiânia (GO), Brasil. 70Conde DM, Morais LC, Pacheco CF, Ferreira RB, Silva EPS, Fonseca PSP, Pinto SA de fibroadenoma. Paciente submeteu-se à remoção cirúrgica do nódulo na axila direita. O exame histopatológico demonstrou fibroadenoma. Decidiu-se por uma conduta conservadora para as mamas acessórias axilares e múltiplos fibroadenomas mamários. Após 11 meses de seguimento, não houve recidiva do nódulo na axila direita nem alterações dos fibroadenomas. A conduta conservadora na mama acessória axilar é possível, porém o tecido mamário acessório pode ser afetado por neoplasia. Nos casos suspeitos de malignidade, a investigação deve ser conduzida com os mesmos recursos propedêuticos utilizados nas mamas normalmente posicionadas. Na presença de múltiplos fibroadenomas nas mamas, a conduta conservadora pode ser adotada com segurança.

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First report of a fibro‐adenoma in axillary mammary tissue of a renal transplant patient taking cyclosporin

Cited by 8 publications

References 21 publications

The Occurrence of Primary Hepatic Adenoma in Deceased Donor Renal Transplant Recipient

The Occurrence of Primary Hepatic Adenoma in Deceased Donor Renal Transplant Recipient

Fibroadenoma of the Axilla in A Patient With Macroprolactinoma

Multiple bilateral fibroadenoma of the breast and axillary accessory breast: case report

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