Transplacental Chikungunya Virus Antibody Kinetics, Thailand

Watanaveeradej,; Tp, Endy; Simasathien, Sriluck; Kerdpanich, Angkool; Polprasert, Napuschon; Aree, Chanchai; Dw, Vaughn; Nisalak, A

doi:10.3201/eid1211.051560

Cited by 33 publications

(22 citation statements)

References 10 publications

(6 reference statements)

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“…We could confirm 15 cases of recent CHIKV infection (4•7%), which included four cases with IgM+/IgG− and 11 cases who had symptomatic CHIKV infection with IgM+/IgG+. We also found a high seroprevalence of DENV infection (90•3%), a rate similar to a previous study from Bangkok, Thailand (96•9%) [13]. However, the seroprevalence of DENV in pregnant women in other countries has been found in previous studies to range from 17% to 53% [20,29].…”

Section: Discussionsupporting

confidence: 91%

Chikungunya and dengue virus infections during pregnancy: seroprevalence, seroincidence and maternal–fetal transmission, southern Thailand, 2009–2010

Laoprasopwattana

Suntharasaj

Petmanee³

et al. 2015

Epidemiol. Infect.

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Limited information is available on the seroprevalence of chikungunya virus (CHIKV) infection and maternal-fetal transmission incidence of CHIKV and dengue virus (DENV) infections during the 2008-2009 CHIKV outbreak in southern Thailand. A community-based post-epidemic seroprevalence study was conducted in parturient women admitted to the Thepa District Hospital in Songkhla Province, Thailand, for delivery from November 2009 to May 2010. The women were tested for chikungunya (CHIK) IgM/IgG and dengue (DEN) IgM/IgG. Cord blood samples were also tested for CHIK IgM or DEN IgM in women who tested positive for CHIK IgM or DEN IgM, respectively. The seroprevalence of CHIKV infection (CHIK IgM or IgG positive) was 227/319 (71·2%) with pre-outbreak seroprevalence (IgM-/IgG+) of 43·6% and the seroprevalence of DENV infection was 288/319 (90·3%). Complications during pregnancy, newborn outcomes and congenital anomalies were not different in those who had recent, remote or no CHIKV infections. None of the newborns whose mothers were CHIK or DEN IgM positive had cord blood positive for both CHIK and DEN IgM. In conclusion, both CHIKV and DENV are endemic in southern Thailand; during the recent CHIKV outbreak CHIK seroprevalence increased from 43·6% to 71·2%.

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Section: Discussionsupporting

confidence: 91%

Chikungunya and dengue virus infections during pregnancy: seroprevalence, seroincidence and maternal–fetal transmission, southern Thailand, 2009–2010

Laoprasopwattana

Suntharasaj

Petmanee³

et al. 2015

Epidemiol. Infect.

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“…As already shown for other maternal–fetal transmitted viruses including hepatitis B virus and West Nile virus, viral neutralization in exposed neonates may constitute a useful approach to prevent neonatal infection. Our study did confirm, at a large scale, the kinetics of transplacental mother-transferred CHIKV-specific IgG antibodies, which lasted longer than 6 mo for more than 50% of La Réunion Island infants [18], as previously demonstrated for Thai children [40]. Whether these passively transferred antibodies exhibit a neutralizing and protective activity remains to be determined.…”

Section: Discussionsupporting

confidence: 83%

Multidisciplinary Prospective Study of Mother-to-Child Chikungunya Virus Infections on the Island of La Réunion

et al. 2008

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BackgroundAn outbreak of chikungunya virus affected over one-third of the population of La Réunion Island between March 2005 and December 2006. In June 2005, we identified the first case of mother-to-child chikungunya virus transmission at the Groupe Hospitalier Sud-Réunion level-3 maternity department. The goal of this prospective study was to characterize the epidemiological, clinical, biological, and radiological features and outcomes of all the cases of vertically transmitted chikungunya infections recorded at our institution during this outbreak.Methods and FindingsOver 22 mo, 7,504 women delivered 7,629 viable neonates; 678 (9.0%) of these parturient women were infected (positive RT-PCR or IgM serology) during antepartum, and 61 (0.8%) in pre- or intrapartum. With the exception of three early fetal deaths, vertical transmission was exclusively observed in near-term deliveries (median duration of gestation: 38 wk, range 35–40 wk) in the context of intrapartum viremia (19 cases of vertical transmission out of 39 women with intrapartum viremia, prevalence rate 0.25%, vertical transmission rate 48.7%). Cesarean section had no protective effect on transmission. All infected neonates were asymptomatic at birth, and median onset of neonatal disease was 4 d (range 3–7 d). Pain, prostration, and fever were present in 100% of cases and thrombocytopenia in 89%. Severe illness was observed in ten cases (52.6%) and mainly consisted of encephalopathy (n = 9; 90%). These nine children had pathologic MRI findings (brain swelling, n = 9; cerebral hemorrhages, n = 2), and four evolved towards persistent disabilities.ConclusionsMother-to-child chikungunya virus transmission is frequent in the context of intrapartum maternal viremia, and often leads to severe neonatal infection. Chikungunya represents a substantial risk for neonates born to viremic parturients that should be taken into account by clinicians and public health authorities in the event of a chikungunya outbreak.

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“…Whether infection of the basolateral side of the membrane was due to cell: cell contact or virus escape into the basolateral media is not known. However, the detection of CHIKV in cells located on either side of the maternal fetal axis in this study supports case reports of CHIKV congenital infections and isolation of CHIKV from placentas [5,6,28,32].…”

Section: Discussionsupporting

confidence: 90%

“…CHIKV has been detected in the placenta and amniotic fluid of infected mothers which supports this platform as an in vitro mechanism for studying the kinetics of congenital CHIKV infections [5,6,28,29]. Virus was quantified via titration in Vero cells and by RT-PCR.…”

Section: Discussionmentioning

confidence: 86%

Antibodies for Venezuelan Equine Encephalitis Virus Protect Embryoid Bodies from Chikungunya Virus

Schultz¹,

Jones²,

Clamp³

et al. 2019

Preprint

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Chikungunya virus (CHIKV) is an alphavirus that causes febrile illness punctuated by severe polyarthralgia. After the emergence of CHIKV in the Western Hemisphere, multiple reports of congenital infections were published that documented neurological complications, cardiac defects, respiratory distress, and miscarriage. The Western Hemisphere is endemic to several alphaviruses and whether antigenic cross-reactivity can impact the course of infection has not been explored. Recent advances in biomedical engineering have produced cell co-culture models that replicate the cellular interface at the maternal fetal axis. We employed a trans-well assay to determine if cross-reactive antibodies affected the movement and replication of CHIKV across placental cells and into an embryoid body. The data show that antibodies to Venezuelan equine encephalitis virus (VEEV) significantly reduced CHIKV viral load in embryoid bodies. The data highlight that viral pathogenesis can be cell-specific and that exploiting antigenic cross-reactivity could be an avenue for reducing the impact of congenital CHIKV infections.

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Transplacental Chikungunya Virus Antibody Kinetics, Thailand

Cited by 33 publications

References 10 publications

Chikungunya and dengue virus infections during pregnancy: seroprevalence, seroincidence and maternal–fetal transmission, southern Thailand, 2009–2010

Chikungunya and dengue virus infections during pregnancy: seroprevalence, seroincidence and maternal–fetal transmission, southern Thailand, 2009–2010

Multidisciplinary Prospective Study of Mother-to-Child Chikungunya Virus Infections on the Island of La Réunion

Antibodies for Venezuelan Equine Encephalitis Virus Protect Embryoid Bodies from Chikungunya Virus

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