Chikungunya and dengue virus infections during pregnancy: seroprevalence, seroincidence and maternal–fetal transmission, southern Thailand, 2009–2010

Laoprasopwattana, Kamolwish; Suntharasaj, Thitima; Petmanee, P.; Suddeaugrai, Oranart; Geater, Alan

doi:10.1017/s0950268815001065

Cited by 36 publications

(42 citation statements)

References 26 publications

(44 reference statements)

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“…If widespread herd immunity for CHIKV exists, previously infected individuals will be protected from reinfection, which would dampen future CHIKV outbreak. Seroprevalence surveys conducted shortly after CHIKV outbreaks in several countries suggest that widespread infection generally declined after ~70% of the individuals have developed antibodies to CHIKV [35]. For DENV, however, cross-protection from heterologous infection is limited.…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of antibodies to dengue and chikungunya viruses in Thailand

et al. 2017

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The abundance of Aedes mosquito species enabled widespread transmission of mosquito-borne chikungunya virus (CHIKV) and dengue virus (DENV) in Southeast Asia. Periodic seroprevalence surveys are therefore necessary to assess the viral burden in the population and the effectiveness of public health interventions. Since the current seroprevalence for CHIKV and DENV in Thailand are unknown, we evaluated evidence of past infection among Thais. Eight-hundred and thirty-five serum samples obtained from individuals living in central and southern Thailand were assessed for anti-CHIKV and anti-DENV IgG antibodies using commercial enzyme-linked immunosorbent assays. Overall, 26.8% (224/835) of individuals were seropositive for CHIKV, the majority of whom were also DENV-seropositive (91.1%, 204/224). Approximately half of all adults in their fifth decade of life had attained CHIKV seropositivity. Children under 15 years of age in southern Thailand were significantly more likely to be CHIKV-seropositive compared to those residing in central Thailand. In contrast, 79.2% (661/835) of Thais were DENV-seropositive, 30.9% (204/661) of whom also had antibodies to CHIKV. CHIKV/DENV dual seropositivity among Thais was 24.4% (204/835). The age-standardized seroprevalence for DENV was three times that of CHIKV (80.5% vs. 27.2%). Relatively high CHIKV seroprevalence among adults living in central Thailand revealed an under-recognized CHIKV burden in the region, while the low-to-moderate transmission intensity of DENV (seroprevalence <50% at 9 years) is expected to reduce the impact of DENV vaccination in Thailand. This most recent seroprevalence data provide serological baselines for two of the most common mosquito-borne viruses in this region.

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Section: Discussionmentioning

confidence: 99%

Seroprevalence of antibodies to dengue and chikungunya viruses in Thailand

et al. 2017

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“…Most of the reports concerning the effect of CHIKV infection during pregnancy describe no major effect on pregnancy outcomes or newborns if the mother was infected before the peripartum period (248)(249)(250). However, CHIKV-specific IgM antibodies were detected in the cord blood of the infants, providing evidence for intrauterine transmission of the virus (249,250).…”

Section: Humansmentioning

confidence: 99%

Emerging Role of Zika Virus in Adverse Fetal and Neonatal Outcomes

et al. 2016

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SUMMARYThe rapid spread of the Zika virus (ZIKV) in the Americas and its potential association with thousands of suspected cases of microcephaly in Brazil and higher rates of Guillain-Barré syndrome meet the conditions for a Public Health Emergency of International Concern, as stated by the World Health Organization in February 2016. Two months later, the Centers for Disease Control and Prevention (CDC) announced that the current available evidence supports the existence of a causal relationship between prenatal Zika virus infection and microcephaly and other serious brain anomalies. Microcephaly can be caused by several factors, and its clinical course and prognosis are difficult to predict. Other pathogens with proven teratogenicity have been identified long before the current ZIKV epidemic. Despite the growing number of cases with maternal signs of infection and/or presence of ZIKV in tissues of affected newborns or fetuses, it is currently difficult to assess the magnitude of increase of microcephaly prevalence in Brazil, as well as the role of other factors in the development of congenital neurological conditions. Meanwhile, health agencies and medical organizations have issued cautious guidelines advising health care practitioners and expectant couples traveling to, returning from, or living in affected areas. Analogous to dengue virus (DENV) epidemics, ZIKV has the potential to become endemic in all countries infested byAedesmosquitoes, while new mutations could impact viral replication in humans, leading to increased virulence and consequently heightened chances of viral transmission to additional naive mosquito vectors. Studies are urgently needed to answer the questions surrounding ZIKV and its role in congenital neurological conditions.

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“…Chikungunya and dengue virus co-infections have been reported from India [4], Thailand [5], Yemen [6] and among returning travelers from Colombia [7] and Angola [8]. As both the viruses share common vector, chikungunya-dengue co-infection is likely to occur elsewhere.…”

Section: Discussionmentioning

confidence: 99%

Chikungunya virus and dengue virus coinfection: a case report from Bangladesh

et al. 2018

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A case of concurrent chikungunya virus and dengue virus infection is reported here. The patient presented with fever and generalized body ache. Diagnostic work-up revealed chikungunya-dengue co-infection. Dengue is endemic in Bangladesh while chikungunya is a recently emerging infection. As both the viruses are transmitted by a common vector, Aedes spp., such co-infections are likely to increase in coming years.

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Chikungunya and dengue virus infections during pregnancy: seroprevalence, seroincidence and maternal–fetal transmission, southern Thailand, 2009–2010

Cited by 36 publications

References 26 publications

Seroprevalence of antibodies to dengue and chikungunya viruses in Thailand

Seroprevalence of antibodies to dengue and chikungunya viruses in Thailand

Emerging Role of Zika Virus in Adverse Fetal and Neonatal Outcomes

Chikungunya virus and dengue virus coinfection: a case report from Bangladesh

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