Introduction: Liposarcoma is the most common tumor in soft tissues, being extremely rare in the esophagus. Its diagnostic approach is difficult due to its clinical presentation, being able to be confused with motor pathologies. The definitive treatment is surgical resection, which, together with anatomopathological analysis, is considered the only diagnostic methods. Case Report: A 59-year-old female, with a clinical picture of 5 years of evolution, retrosternal pain accompanied by gastroesophageal reflux, progressive dysphagia, weight loss, and dyspnea. She was assessed with endoscopy and tomography showing a polypoid pedunculated lesion in the esophagus, on which is performed surgical treatment with a resection, diagnosing liposarcoma. Conclusion: Liposarcoma is the most common tumor found in soft tissues, being a disease of very low incidence in the esophagus. It is a slow-growing neoplasm, with uncertain pathophysiology, reaching sufficient size late in its diagnostic approach, developing obstructive symptoms in the superior digestive tract, and in more severe cases, affecting the airway. It appears mostly in adults, and surgical resection and anatomopathological analysis are the definitive surgical treatments and methods of choice for diagnosis.