Transmural Dispersion of Repolarization Determines Scroll Wave Behavior During Ventricular Tachyarrhythmias  - A Simulation Study -

Haraguchi, Ryo; Ashihara, Takashi; Namba, T.; Tsumoto, Kunichika; Murakami, Shingo; Kurachi, Yoshihisa; Ikeda, Takanori; Nakazawa, Kimitaka

doi:10.1253/circj.cj-10-0071

Cited by 12 publications

(15 citation statements)

References 35 publications

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“…Many physiological studies have attempted to reproduce the functions of tissues/organs such as cardiac contractions [72], skeletal muscle function [73] and pulmonary gas exchange [74] in simulations. High specification computers have been used to perform the calculations in these cases.…”

Section: Resultsmentioning

confidence: 99%

Systems‐based understanding of pharmacological responses with combinations of multidisciplinary methodologies

Kariya

Honma

Suzuki

2013

Biopharm & Drug Disp

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The importance of systems-based pharmacological approaches to drug discovery and development has increasingly been recognized. This reviews summarizes recent advances in the development of systems pharmacology and introduces the methods used for analysis. To understand the cellular response at the molecular level, pathway maps must be prepared to show how the function of the constituent molecules within cells are linked and integrated to form molecular networks. First, the methods used to prepare these pathway maps, such as databases, knowledge bases and software platforms, are introduced. Then the mathematical theories used to analyse the behavior of molecular networks are summarized. To quantitatively predict cellular responses, simulations are performed that are based on the rate equations for each reaction within the pathway map. If the number of reactions described in the pathway map is small, and if the parameter values for the rate constants are available, it is possible accurately to simulate the behavior of the molecular networks. However, to analyse complex maps, mathematical abstraction is required. Such abstraction methods are important to integrate cellular responses and to understand tissue/organ and in vivo pharmacological/toxicological responses. The scope and limitations of the methods are also discussed.

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Section: Resultsmentioning

confidence: 99%

Systems‐based understanding of pharmacological responses with combinations of multidisciplinary methodologies

Kariya

Honma

Suzuki

2013

Biopharm & Drug Disp

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“…Increased sympathetic activity and varying cardiac autonomic functions are closely associated with a heterogeneity of ventricular repolarization and the risk of ventricular arrhythmia 31 . In another study, it was demonstrated by a mechanical method that the degree of increase in transmural myocardial repolarization time might indicate the degree of sustained ventricular tachycardia 32 . In one study, it was shown that the Tp‐e interval increased by sympathetic ganglion stimulation but not intravenous norepinephrine infusion 33 .…”

Section: Discussionmentioning

confidence: 99%

Variation of Tpeak‐end, corrected Tpeak‐end, QT, and corrected QT intervals, Tpeak‐end/QT, Tpeak‐end/corrected QT ratios and heart rate variability according to decades in the healthy male subjects aged between 30 and 79 years

Cosgun

Oren

2020

Journal of Arrhythmia

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This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. AbstractBackground: Heart rate variability (HRV) is a predictor of cardiac autonomic functions. Ventricular repolarization markers can indicate ventricular arrhythmias. We aimed to evaluate variations of HRV and these repolarization markers in five healthy male groups between age 30 and 79 years according to decades. Materials and Methods:The study group consisted of 500 healthy male subjects between October 2018 and May 2019. The male subjects were divided into five categories according to their ages. Then, electrocardiograms (ECG), transthoracic echocardiograms (TTE), and treadmill exercise test (TET) were performed. T-wave peak-end (Tp-e) interval was defined as the time between the peak point and end of T-wave. Tp-e, corrected Tp-e (cTp-e), QT, and corrected QT (QTc) were measured from the resting ECGs and HRV temporal parameters (SDNN, SDNN Index, SDANN Index, RMSSD, sNN50, and pNN50), and HRV frequency parameters (VLF, LF, HF, and LF/HF) were obtained from 24-hour Holter monitorization recordings. One-way ANOVA test was used for the differences between the groups. Pearson correlation test was used to determine the correlations between the values of all groups. Results:Considering the repolarization parameters, there are significant differences in five groups in terms of Tp-e interval, but not Tp-e/QT and Tp-e/QTc ratios.Considering the HRV parameters, there were statistically significant differences between the five male healthy groups in terms of HRV temporal parameters and there are no significant differences in terms of HRV frequency parameters. Conclusion:As the age increases, basal Tp-e interval increases and HRV temporal parameters decrease significantly in the male subjects aged between 30 and 79 years, but HRV frequency parameters do not change. K E Y W O R D Shealthy male subjects, heart rate variability, Tp-e interval, Tp-e/QT ratio, Tp-e/QTc ratio, variation according to decades | 509 COSGUN aNd OREN

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“…As a quantitative index of TDR, the Tp-e interval exerts an important guiding significance on predictions of ventricular arrhythmia and evaluation of the risk therein. The conduction of excitation can be influenced when the Tp-e interval is prolonged, causing reentry and even inducing TdP [25–27]. The Tp-e interval is normally in the range of 85 ± 11 ms with an upper limit of 110 ms in white and Hispanic women [28].…”

Section: Discussionmentioning

confidence: 99%

A Comparison of the Effect of Sevoflurane and Propofol on Ventricular Repolarisation after Preoperative Cefuroxime Infusion

Gao

Wang

et al. 2019

BioMed Research International

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The aim of this study is to investigate the changes in QT, QTc, and Tp-e intervals and Tp-e/QT ratio on surface electrocardiogram (ECG) signals during anaesthesia induction using propofol or sevoflurane after preoperative cefuroxime infusion. Some 120 cases of gynaecological patients are randomly divided into propofol (P) and sevoflurane (S) groups (n=60). After cefuroxime (1.5 g) was infused in the two groups of patients, propofol target controlled infusion (TCI) was conducted in the P group for 5 min to realise a plasma concentration of 4 μg/ml while patients in the S group inhaled anaesthesia by infusing 1.3 MAC sevoflurane for 6 min. The 12-lead ECGs were separately collected before infusing cefuroxime (T1), after infusing cefuroxime (T2), and after infusing propofol or sevoflurane (T3) to measure QT and Tp-e intervals, calculate QTc and Tp-e/QT, and record MAP and HR. Finally, we demonstrated that QT, QTc, and Tp-e intervals and Tp-e/QT ratio had no change (P > 0.05) after cefuroxime infusion in the two groups of patients compared with that before infusing antibiotics. Moreover, after conducting preoperative cefuroxime infusion, using propofol and sevoflurane had no influence on Tp-e interval, but sevoflurane can significantly prolong QT and QTc intervals (P < 0.05).

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Transmural Dispersion of Repolarization Determines Scroll Wave Behavior During Ventricular Tachyarrhythmias - A Simulation Study -

Cited by 12 publications

References 35 publications

Systems‐based understanding of pharmacological responses with combinations of multidisciplinary methodologies

Systems‐based understanding of pharmacological responses with combinations of multidisciplinary methodologies

Variation of Tpeak‐end, corrected Tpeak‐end, QT, and corrected QT intervals, Tpeak‐end/QT, Tpeak‐end/corrected QT ratios and heart rate variability according to decades in the healthy male subjects aged between 30 and 79 years

A Comparison of the Effect of Sevoflurane and Propofol on Ventricular Repolarisation after Preoperative Cefuroxime Infusion

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