Transmission of tubercle bacilli: The effects of chemotherapy

The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis

“…How long, if at all, do patients with MDR tuberculosis require isolation or separation in hospital, and do they actually require hospitalisation for transmission-control purposes? On the basis of household contact studies, Rouillon and colleagues 465 in 1976 first proposed 2 weeks of effective treatment as the minimum duration necessary to render tuberculosis patients non-infectious. The authors emphasise that most patients are not smear-negative or culture-negative after 2 weeks (converting, on average, at about 2 months), concluding that smear and culture predicted patient infectiousness before the onset of effective therapy, but not once started.…”

Misdiagnosis of tuberculosis: Sputum culture is a useful diagnostic tool in Quetta, Pakistan

“…Detection of most of the infectious cases of pulmonary tuberculosis is an indispensable component of the TB control (Rouillon et al, 1976). The diagnosis may be possible by various approaches including sign and symptoms investigations, chest x-ray findings, sputum smear microscopy, sputum culture, and MTB PCR (Lydia et al, 2004).…”

Impacto económico-social del Programa Nacional de Control de la Tuberculosis (PNCT) en la población cubana

“…Desde entonces se insistía en la importancia estratégica del tratamiento breve (Rouillon et al, 1976;OPS, 1979aOPS, , 1979cWHO, 1991b;Sudre et al, 1992;OMS, 1993). ¿ Serían necesarias nuevas drogas antituberculosas o tal vez bastaría con mejorar la organización del tratamiento?…”