Transmission of the hepatitis-C virus by tissue transplantation.

Risk of virus transmission through femoral head allografts: A Belgian appraisal

“…22 The same holds true for HCV for which a secondgeneration of antibody detection in 1992 could detect two reactive cases amongst 470 negative sera from previously negatively tested donors with the first-generation anti-HCV assay. 7 A third generation with better performance is available since 1996. 23 Syphilis testing is even today recommended.…”

“…7,28,29 By eliminating bone marrow and blood, there is no more risk for Rhesus sensitization as described with frozen, nonprocessed bone. 30,31 In removing bone marrow from the cancellous bone of the femoral neck, the risk to transplant occult pathological conditions is further decreased.…”

“…have caused CreutzfeldteJakob disease 9,10 Although HIV virus is the most present in the media, Hepatitis B virus (HBV) is the most prevalent and as such carries more risks for transmission. 7,11 Procedures have been developed to ensure the supply of safe bone. 2,12 These procedures include guidelines on donor selection, tissue quarantine and tissue processing.…”

Influence of Freeze-Drying and Irradiation on Mechanical Properties of Human Cancellous Bone: Application to Impaction Bone Grafting

“…The radiosensitivity of hepatitis viruses is higher and clinical data suggest that hepatitis Ccontaminated tissues did not transmit the virus after irradiation (67,68). While high inactivation rate have been achieved with 50 kGy doses in virus infected bone allografts model (69,70), it is actually concluded that gamma irradiation should be disregarded as a significant isolated virus inactivation method for bone allografts.…”

Quality Control in Hospital Bone Banking

“…Recommendations concerned donor screening, testing and re-testing of living donors after 6 months. The constant update for screening of donors for infectious diseases proved to be important in the subsequent years with two reports on transmission of hepatitis C virus by bone allografts (Eggen & Nordbø 1992;Conrad et al 1995). In the following years tissue banks developed better techniques for processing and preparation of bone allografts and more reliable blood tests came to market (Busch 1991(Busch , 1994Alter et al 1990).…”