Transmission of Cervical Cancer-Associated Human Papilloma Viruses from Mother to Child

Cason, John; Rice, Philip; Best, Jennifer M.

doi:10.1159/000024939

Cited by 20 publications

(18 citation statements)

References 39 publications

(60 reference statements)

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“…The risk of infection in vaginal delivery is low, and cesarean section is not recommended if the pregnant woman is found to have genital HPV infection . As per the systematic meta‐analysis by Medeiros et al.…”

Section: Resultsmentioning

confidence: 99%

Possible non‐sexual modes of transmission of human papilloma virus

Sabeena

Bhat

Kamath

et al. 2017

J of Obstet and Gynaecol

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Aim: There is strong evidence to suggest vertical and horizontal modes of transmission of human papilloma virus (HPV), an established etiologic agent of cervical cancer. Infants, children, and adults can acquire both high-risk and low-risk infections by birth or by close contact even though HPV is mainly transmitted sexually. A thorough review of the literature was performed to assess the possible non-sexual modes of transmission of HPV. Methods: An electronic search of databases for review articles, cross-sectional studies, cohort studies, and case reports on non-sexual modes of transmission among sexually unexposed women and children was carried out using search terms such as "human papilloma virus, HPV, transmission, horizontal transmission, vertical transmission, and fomites". Articles published between 1983 and 2015 were retrieved. Results: Epidemiological and clinical data support various non-sexual modes of transmission especially at the time of birth and by close contact. Even though the role of fomites in the transmission of HPV is not well established, HPV-DNA positivity has been reported in transvaginal ultrasound probes and colposcopes after routine disinfection. Conclusion: Awareness needs to be spread among the public about alternate modes of transmission. For a proper understanding of the exact natural history of HPV infection acquired via the non-sexual route, long-term prospective studies need to be undertaken.

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Section: Resultsmentioning

confidence: 99%

Possible non‐sexual modes of transmission of human papilloma virus

Sabeena

Bhat

Kamath

et al. 2017

J of Obstet and Gynaecol

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“…Thirty years later, maternal HPV infection was linked to these lesions. 12,22,33,34 The possible mechanisms of vertical transmission are not well understood. HPV DNA has been isolated from the vas deferens, seminal fluid, and spermatozoa.…”

Section: Modes Of Transmissionmentioning

confidence: 99%

Human Papillomavirus in Infants: Transmission, Prevalence, and Persistence

LaCour

Trimble

2012

Journal of Pediatric and Adolescent Gynecology

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“…The large number of mother-infant pairs analyzed made it possible to explore the consequences of the presence of HPV in the placenta, umbilical cord blood and breast milk. Studies supporting perinatal HPV transmission have been reviewed by two separate research teams, one at the Department of Virology at Kings College in London, UK (51) and the other at the University of Turku, Finland (52). However, these reports (51,52) have been met with skepticism as regards definitive interpretation.…”

Section: Hpv In Children: a Brief Overviewmentioning

confidence: 99%

“…Studies supporting perinatal HPV transmission have been reviewed by two separate research teams, one at the Department of Virology at Kings College in London, UK (51) and the other at the University of Turku, Finland (52). However, these reports (51,52) have been met with skepticism as regards definitive interpretation. Nevertheless, the potential impact of early acquired HPV neonatal infection on the efficacy of current vaccines for HPV-positive children remains undetermined.…”

Section: Hpv In Children: a Brief Overviewmentioning

confidence: 99%

The paediatric story of human papillomavirus (Review)

2014

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Human papillomavirus (HPV) is composed of a particularly heterogeneous family of DNA viruses, which has gained much attention in recent years due to the discoveries of Professor Harald zur Hausen, who first identified a connection between HPV and cervical cancer. Professor Harald zur Hausen, the ‘Father of HPV Virology’, was the recipient of the 2008 Nobel Prize. HPV can be transmitted through physical contact via autoinoculation or fomites, sexual contact, as well as vertically from the HPV-positive mother to her newborn, causing subclinical or clinical infections. In infancy and childhood, HPV-associated clinical infections include skin warts, genital warts and juvenile recurrent respiratory papillomatosis, while cervical squamous intraepithelial lesions have also been reported among adolescent girls. To date, several research teams, worldwide, have extensively investigated HPV from the paediatric point of view. This primitive effort has been performed before the recent great expansion of paediatric HPV research due to the vaccination programmes against HPV, which were introduced into clinical practice in 2006. In this review article, we present a brief overview of paediatric HPV research after the first report in 1978 involving children in the research of HPV until the time point of this great expansion. In the future, it is expected that further unresolved issues will be addressed and clarified, as the paediatric story of HPV remains a challenging research target.

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Transmission of Cervical Cancer-Associated Human Papilloma Viruses from Mother to Child

Cited by 20 publications

References 39 publications

Possible non‐sexual modes of transmission of human papilloma virus

Possible non‐sexual modes of transmission of human papilloma virus

Human Papillomavirus in Infants: Transmission, Prevalence, and Persistence

The paediatric story of human papillomavirus (Review)

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