Transmission of a Newly Characterized Strain of Varicella‐Zoster Virus from a Patient with Herpes Zoster in a Long‐Term‐Care Facility, West Virginia, 2004

Lopez, Adriana; Burnett‐Hartman, Andrea N.; Nambiar, Ram; Ritz, Linda; Owens, Pamela L; Loparev, Vladimir N.; Güriş, Dalya; Schmid, Daniela

doi:10.1086/527419

Cited by 99 publications

(60 citation statements)

References 27 publications

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“…There were no unusual features in this clade 2 strain. The clade 5 sample (KY037797) contained the same vaccine-specific SNP at ORF62 position 107252 (reference sequence: Dumas strain, accession #NC001348) [7].…”

Section: Resultsmentioning

confidence: 99%

Revisiting the genotyping scheme for varicella-zoster viruses based on whole-genome comparisons

Jensen

Rivailler

Tseng

et al. 2017

Journal of General Virology

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We report whole-genome sequences (WGSs) for four varicella-zoster virus (VZV) samples from a shingles study conducted by Kaiser Permanente of Southern California. Comparative genomics and phylogenetic analysis of all published VZV WGSs revealed that strain KY037798 is in clade IX, which shall henceforth be designated clade 9. Previously published single nucleotide polymorphisms (SNP)-based genotyping schemes fail to discriminate between clades 6 and VIII and employ positions that are not clade-specific. We provide an updated list of clade-specific positions that supersedes the list determined at the 2008 VZV nomenclature meeting. Finally, we propose a new targeted genotyping scheme that will discriminate the circulating VZV clades with at least a twofold redundancy. Genotyping strategies using a limited set of targeted SNPs will continue to provide an efficient 'first pass' method for VZV strain surveillance as vaccination programmes for varicella and zoster influence the dynamics of VZV transmission.

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Section: Resultsmentioning

confidence: 99%

Revisiting the genotyping scheme for varicella-zoster viruses based on whole-genome comparisons

Jensen

Rivailler

Tseng

et al. 2017

Journal of General Virology

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“…Lopez ve ark. (7) bakım merkezinde zona zosterli bir hastadan kaynaklandığı düşünülen küçük bir salgın bildirmiş-lerdir. Zona zosterli hastadan sonra üç kişi-de suçiçeği gelişmiş, zona zosterli hastalar ile suçiçeği gelişen kişiler arasında doğru-dan temas bulunmaması nedeniyle bulaşın, havayolu ile olduğu ihtimalinden bahsetmişlerdir.…”

Section: Discussionunclassified

“…Varisella zoster virüsü; havayolu, damlacık ve lezyonlardan direkt temas ile bulaşabilmektedir (10,12) . Suçiçeği veya zona zoster ile infekte bireylerin çevrelerindeki yüzeylerde, hava filtrelerinde VZV saptanmıştır (7) . Mevcut infeksiyon kontrol önlemleri zona lezyonlarının üstü örtülü olduğu sürece toplum içinde bulunmasına izin verirken, yeni bulgular bulaşı engellemek için lezyonun üstünün kapalı olmasının yeterli olmayabileceğini göstermektedir (7,9) .…”

Section: Introductionunclassified

“…Suçiçeği veya zona zoster ile infekte bireylerin çevrelerindeki yüzeylerde, hava filtrelerinde VZV saptanmıştır (7) . Mevcut infeksiyon kontrol önlemleri zona lezyonlarının üstü örtülü olduğu sürece toplum içinde bulunmasına izin verirken, yeni bulgular bulaşı engellemek için lezyonun üstünün kapalı olmasının yeterli olmayabileceğini göstermektedir (7,9) . Günümüz koşullarında seroprevalansı düşen bu hastalık, seronegatif erişkin olgularda görülmeye devam etmektedir.…”

Section: Introductionunclassified

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Chickenpox Disease After the Zona Zoster Infection

Uyan¹,

Pullukçu²,

Taşbakan³

et al. 2017

Ankem Derg

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ÖZET GİRİŞSuçiçeği; Varisella Zoster Virüsü'nün (VZV) etken olduğu, genellikle çocuklarda gelişen, veziküller lezyonlar ve ateş yüksek-liği ile seyreden bir hastalıktır. İnkübasyon süresi 10-21 gündür. Virüs, infeksiyonun geçirilmesi sonrası dorsal kök ve gangliyonlarda latent olarak kalmaktadır. Latent virü-sün reaktivasyonu sonrası bulunduğu dermatomda ağrı ile gelişen veziküler dökün-tülü zona zoster infeksiyonu gelişebilmek-tedir. Zona zoster gelişimi açısından en önemli risk faktörleri; ileri yaş, malignite, diyabetes mellitus ve immün supresif ilaç kullanımıdır (1,2,6) .

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“…In subjects with herpes zoster, the horizontal transmission rate is 16% of susceptible contacts [284] . Transmission primarily arises from the exposed skin lesions of immunocompromised subjects or subjects with disseminated zoster, and is rare if the lesions are not exposed [16,17,[285][286][287][288][289] . The risk of fetal infection is virtually zero: Localised maternal zoster (the few published data estimate 0.15-2 cases of herpes/1000 pregnancies [90,147,290,291] ) does not seem to be associated with fetal or in utero infection, nor with post-natal infection because newborns are protected by passively transmitted maternal antibodies [56,90,145,147,166,173,191] .…”

Section: Risk Of Transmissionmentioning

confidence: 99%

Microbiology laboratory and the management of mother-child varicella-zoster virus infection

Paschale

Clerici

2016

WJV

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Varicella-zoster virus, which is responsible for varicella (chickenpox) and herpes zoster (shingles), is ubiquitous and causes an acute infection among children, especially those aged less than six years. As 90% of adults have had varicella in childhood, it is unusual to encounter an infected pregnant woman but, if the disease does appear, it can lead to complications for both the mother and fetus or newborn. The major maternal complications include pneumonia, which can lead to death if not treated. If the virus passes to the fetus, congenital varicella syndrome, neonatal varicella (particularly serious if maternal rash appears in the days immediately before or after childbirth) or herpes zoster in the early years of life may occur depending on the time of infection. A Microbiology laboratory can help in the diagnosis and management of mother-child infection at four main times: (1) when a pregnant woman has been exposed to varicella or herpes zoster, a prompt search for specific antibodies can determine whether she is susceptible to, or protected against infection; (2) when a pregnant woman develops clinical symptoms consistent with varicella, the diagnosis is usually clinical, but a laboratory can be crucial if the symptoms are doubtful or otherwise unclear (atypical patterns in immunocompromised subjects, patients with post-vaccination varicella, or subjects who have received immunoglobulins), or if there is a need for a differential diagnosis between varicella and other types of dermatoses with vesicle formation; (3) when a prenatal diagnosis of uterine infection is required in order to detect cases of congenital varicella syndrome after the onset of varicella in the mother; and (4) when the baby is born and it is necessary to confirm a diagnosis of varicella (and its complications), make a differential diagnosis between varicella and other diseases with similar symptoms, or confirm a causal relationship between maternal varicella and malformations in a newborn. Core tip: Although varicella during pregnancy is infrequent and congenital varicella syndrome (CVS) is rare, every available means should be used to prevent and diagnose them. Microbiology laboratories can be crucial in these situations: Evaluating a mother's immune status with sensitive and specific tests for the detection of antibodies; allowing a rapid diagnosis with molecular biology tests when a clinical manifestation may be due to different etiologies; following pregnant women with varicella for the prenatal diagnosis of CVS with close collaboration between molecular biology investigators and specialists in imaging diagnostics.De Paschale M, Clerici P. Microbiology laboratory and the management of mother-child varicella-zoster virus infection. World

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Transmission of a Newly Characterized Strain of Varicella‐Zoster Virus from a Patient with Herpes Zoster in a Long‐Term‐Care Facility, West Virginia, 2004

Cited by 99 publications

References 27 publications

Revisiting the genotyping scheme for varicella-zoster viruses based on whole-genome comparisons

Revisiting the genotyping scheme for varicella-zoster viruses based on whole-genome comparisons

Chickenpox Disease After the Zona Zoster Infection

Microbiology laboratory and the management of mother-child varicella-zoster virus infection

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