Transmissibility of Hepatitis B Virus (HBV) Infection through Blood Transfusion from Blood Donors with Occult HBV Infection

Abstract

OHB donor blood infectivity was shown in our animal and human studies. However, the risk of HBV transmission in humans was low, especially from blood products obtained from donors with OHB who were anti-HBs positive.

Prevalence of HBV DNA among 20 million seronegative blood donations in China from 2010 to 2015

“…From 2010 to 2015, many blood banks began to implement NAT screening. The prevalence of HBV DNA among seronegative blood donations has been reported in other countries and several blood banks of China91011. However, to date, no study has reported on the frequency of HBV DNA positivity among seronegative blood donors throughout China.…”

Multiple HBV transfusion transmissions from undetected occult infections: revising the minimal infectious dose

“…However, one in four recipients of BD1 FFP and three/six recipients of BD2 FFP were not infected, suggesting that in these OBIs with very low viral load, fluctuation of HBV DNA levels was present as described in OBI with higher viral load 7 13 16. This series of patients provided the opportunity to revise the predicted OBI infectious dose of 1049 copies (range 117–3441) or 197 IU on the basis of clinical data,9 and of 316 copies or ~60 IU when derived from a mathematical model 23…”

Occult hepatitis B infection in blood donors from South East Asia: molecular characterisation and potential mechanisms of occurrence

“…In South East Asia, where genotypes B and C are prevalent, up to 90% of the population has evidence of past exposure to HBV 5–7. The prevalence of OBI previously reported among blood donors in Asia is 1:570–1:7517 in China,4 8 1:3248 in Hong Kong,9 1:894–1:1029 in Taiwan7 10 and 1:3832 in Thailand 11…”