Prevalence of HBV DNA among 20 million seronegative blood donations in China from 2010 to 2015

Abstract

The prevalence of HBV DNA among seronegative blood donations in China has not been studied extensively on a nationwide scale. The aim of this study was to analyse the prevalence, trend, distributions, and serological characteristics of HBV DNA positive/seronegative blood donations. We collected HBV test data from all blood banks of China from 2010 to 2015 and performed supplemental serological tests and quantitative detection of HBV DNA of the seronegative/HBV DNA positive blood donations. We analysed the prevalence of HBV DNA among seronegative blood donations screened by varying nucleotide acid test (NAT) reagents. The analysis results showed that a total of 20,084,187 seronegative blood donations were screened by NAT from 2010 to 2015 in China. The average frequency of HBV DNA among seronegative blood donations was 1/1482, but there has been a steady increase from 1/1861 in 2011 to 1/1269 in 2015. The geographical distribution of seronegative and HBV DNA positive blood donations was roughly consistent with that of HBsAg. The most common serological pattern was HBeAb and HBcAb positive. In conclusion, our study offeres fundamental data of seronegative and HBV DNA positive blood donations throughout China.

Estimation of hepatitis B–positive rates in Chinese blood donors by combining predonation and postdonation screening results

“…Because NAT was not implemented in Mianyang until January 2016, we used an estimated SC–/NAT+ rate (0.158%) for Mianyang based on their actual rate in 2016. This rate is similar to the regional SC–/NAT+ rate reported from a recent study of a total of 20,084,187 SC– donations from 2010 to 2015 …”

“…In Chongqing blood center, 88 donors with window period or occult HBV infection donations were intercepted in 2015. According to a national report of HBV NAT yield among Chinese blood centers based on quantitative detection of HBV in selected seronegative and HBV DNA–positive blood donations, the average HBV DNA positive rate was one in 1482, with an increase from one in 1861 in 2011 to one in 1269 in 2015 when data from more regions were included over the years. Recent nationwide implementation of NAT in Chinese blood banks should substantially reduce the HBV residual risks.…”

“…This rate is similar to the regional SC-/NAT+ rate reported from a recent study of a total of 20,084,187 SC-donations from 2010 to 2015. 1 In this study, the overall HBsAg-positive rate is calculated as P1 = (D1 + D2)/T; the overall HBV-positive rate (HBsAg+ HBV NAT) was P2 = (D1 + D2 + D3)/T, where D1 is the estimated number of NT+ among predonation HBsAg RT+ deferrals in 2015, D2 is the number of NT+ donors among postdonation ELISA SC+ donors in 2015, D3 is the number of postdonation SC-/NAT+ donors in 2015, and T is the total number of donors presented to make WB donations, including HBsAg RT+ donors and all other predonation deferrals, as well as eligible donors who made successful WB donations.…”

“…Hepatitis B virus (HBV) infection is a major global public health problem. Approximately 93 million chronically infected individuals live in China where 7.2% of those under 59 years are HBV infected . The high HBV prevalence among eligible blood donors continuously poses threats to Chinese blood safety.…”

“…Approximately 93 million chronically infected individuals live in China where 7.2% of those under 59 years are HBV infected. 1,2 The high HBV prevalence among eligible blood donors continuously poses threats to Chinese blood safety. The standard donor selection and donation screening (SC) process implemented in late 1990s has significantly reduced the transfusion-transmitted HBV infection rate.…”