2007
DOI: 10.1038/sj.emboj.7601796
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Transmembrane mucins Hkr1 and Msb2 are putative osmosensors in the SHO1 branch of yeast HOG pathway

Abstract: To cope with life‐threatening high osmolarity, yeast activates the high‐osmolarity glycerol (HOG) signaling pathway, whose core element is the Hog1 MAP kinase cascade. Activated Hog1 regulates the cell cycle, protein translation, and gene expression. Upstream of the HOG pathway are functionally redundant SLN1 and SHO1 signaling branches. However, neither the osmosensor nor the signal generator of the SHO1 branch has been clearly defined. Here, we show that the mucin‐like transmembrane proteins Hkr1 and Msb2 ar… Show more

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Cited by 205 publications
(268 citation statements)
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“…Recently a second mucin-like protein, Hkr1, was shown to function together with Msb2 as an osmosensor in the S. cerevisiae Hog1 pathway (Tatebayashi et al, 2007). We detected single orthologues of Msb2, but not Hkr1, in all species studied except for S. pombe and R. oryzae.…”
Section: The Fus3 and Kss1 Mapk Pathwaysmentioning
confidence: 74%
“…Recently a second mucin-like protein, Hkr1, was shown to function together with Msb2 as an osmosensor in the S. cerevisiae Hog1 pathway (Tatebayashi et al, 2007). We detected single orthologues of Msb2, but not Hkr1, in all species studied except for S. pombe and R. oryzae.…”
Section: The Fus3 and Kss1 Mapk Pathwaysmentioning
confidence: 74%
“…More recently, two membrane mucin-like molecules, Msb2p and Hkr1p, have been implicated as osmosensors that also function in the SHO1 branch of the HOG pathway (Tatebayashi et al, 2007). Genetically, Opy2p functions at or above the level of Ste50p/Ste11p at or downstream of Sho1p (Wu et al, 2006) and downstream of Msb2p and Hkr1p (Tatebayashi et al, 2007).…”
Section: Introductionmentioning
confidence: 99%
“…Two input branches, the SLN1, 16,17 and SHO1 [18][19][20] branch, converge on the core MAP kinase kinase Pbs2. These two branches are redundant for cell survival under conditions of moderate osmotic stress.…”
Section: Resultsmentioning
confidence: 99%