Translocation t(14;18)/<i>IGH‐BCL2</i> in gastrointestinal follicular lymphoma

Yanai, Shunichi; Nakamura, Shotaro; Takeshita, Morishige; Fujita, Katsuhiko; Hirahashi, Minako; Kawasaki, Keisuke; Kurahara, Koichi; Sakai, Yuji; Matsumoto, Takayuki

doi:10.1002/cncr.25811

Cited by 17 publications

(9 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For the group of patients with disseminated lymphoma, the rate was 83%, in accordance with other studies (Kuppers 2005). Thus, this difference in frequency of t(14;18) might not only be related to the stage of disease at presentation (Weinberg et al 2009), but also dependent on the anatomical site (Yanai et al 2010). …”

Section: Discussionsupporting

confidence: 88%

“…Approximately 10% of follicular lymphomas arises in extranodal site (Armitage & Weisenburger 1998). This subgroup of follicular lymphomas differs from nodal follicular lymphomas with regard to histopathological, genetic and clinical characteristics (Goodlad et al 2004;Weinberg et al 2009;Yanai et al 2010;Fern andez de et al 2011).…”

Section: Introductionmentioning

confidence: 99%

“…The chromosomal translocation t(14;18)(q32;q21), involving the immunoglobulin heavy gene (IGH) and the BCL2 gene, is the genetic hallmark of follicular lymphoma with a prevalence of approximately 85% (Horsman et al 1995;Knutsen 1997). Variable rates of t(14;18) have been reported in extranodal follicular lymphomas occurring at different anatomical sites (Goodlad et al 2004;Weinberg et al 2009;Yanai et al 2010). This indicates sitespecific differences.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Follicular lymphoma of the ocular adnexal region: A nation‐based study

Rasmussen

Ralfkiær

Prause

et al. 2014

Acta Ophthalmologica

View full text Add to dashboard Cite

ABSTRACT.Purpose: To characterize the clinicopathological features of follicular lymphoma of the ocular adnexal region. Methods: Retrospective nation-based study of Danish patients with ocular adnexal follicular lymphoma from January 1st 1980 through December 31st 2009. Results: Twenty-four patients with ocular adnexal follicular lymphoma were identified. Fourteen (58%) of the patients were females. The median age was 63 years (range: 42-96 years). Eleven (46%) of the patients had primary ocular adnexal lymphoma, seven (29%) had an ocular adnexal lesion in conjunction with a concurrent systemic lymphoma and six patients (25%) presented with an ocular adnexal relapse. The most frequently affected sites were the lacrimal gland (38%) and the orbit (33%). Thirteen patients (54%) presented with Ann Arbor stage IE lymphoma, four (17%) had stage IIE, two patients (8%) stage IIIE, and five patients (21%) had stage IV lymphoma. Radiotherapy was primarily used in patients with primary lymphoma and those with a stage IE/IIE relapse (82%), while stage IIIE/IV lymphomas most frequently received alkylating chemotherapy (67%). Complete remission was observed in 19 of the patients (79%), but of these 11(58%) had a relapse. The 10-year overall survival for the entire cohort was 59%. The translocation t(14;18) was detected in 16 patients (16/24, 76%). Recurrence was only observed in patients with the t(14;18) (p = 0.05, log-rank). Conclusions: Ocular adnexal follicular lymphoma is more commonly found in elderly female patients. The lacrimal gland is relatively frequently involved. Radiotherapy is the treatment of choice for localized ocular adnexal follicular lymphoma providing a favourable prognosis for majority of patients.

show abstract

Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Follicular lymphoma of the ocular adnexal region: A nation‐based study

Rasmussen

Ralfkiær

Prause

et al. 2014

Acta Ophthalmologica

View full text Add to dashboard Cite

show abstract

“…The initial treatment may be radiotherapy, systemic chemotherapy, monoclonal antibody monotherapy, a combination of these therapies or a 'watch and wait' policy (3)(4)(5). Several studies have stated that the watch and wait strategy can be an acceptable initial approach due to the indolent nature of this disease entity (2,3,12,(26)(27)(28). On the other hand, for limited-stage follicular lymphoma of nodal origin, radiotherapy is recommended as the preferred treatment with curative potential (2,29).…”

Section: Discussionmentioning

confidence: 99%

A multicenter survey of enteroscopy for the diagnosis of intestinal follicular lymphoma

et al. 2015

View full text Add to dashboard Cite

Abstract. The importance of enteroscopy examinations to investigate the entire length of the small intestines has been emphasized in follicular lymphoma patients with intestinal involvement. The aim of the present study was to determine the current state of enteroscopy examinations, including the performance rate, and the prevalence of small intestinal lesions in a patient population in Japan. A retrospective multicenter survey of 17 institutions collected the case information of 110 follicular lymphoma patients with gastrointestinal involvement. The results of the enteroscopy examinations were reviewed, and in order to identify potential factors affecting the performance rate of enteroscopy, patient gender, age at lymphoma diagnosis, histopathological grade, clinical stage, the date of the initial diagnosis and the annual volume of enteroscopy at the institution were compared between the patients who underwent one or more enteroscopy procedures and the patients who did not undergo enteroscopy. A total of 34 patients (30.9%) underwent enteroscopy, and 24 of these (70.6%) presented with involvement in the jejunum and/or ileum. It was found that more patients diagnosed in recent years and more patients treated at an ultra-high volume institution (≥101 enteroscopy examinations/year) underwent an enteroscopy. In conclusion, although the prevalence of small intestinal lesions was high (70.6%) in the follicular lymphoma patients presenting with intestinal involvement, the performance rate of enteroscopy was only 30.9%, and thus the majority of the patients have not undergone enteroscopy examinations. Further investigation is required to define the clinical significance of enteroscopy at the initial diagnostic work-up and during the follow-up period of these patients.

show abstract

“…Patients with histological grade 1 or 2 tumors were more likely to have the t(14;18) translocation than not. In addition, the complete response rate was lower in the t(14;18)-positive group compared to the t(14;18)-negative group, and a trend toward less favorable event-free survival was observed in the t(14;18)-positive group (12). Achieving bcl-2/IgH negativity following FL therapy results in a better prognosis (13).…”

Section: Discussionmentioning

confidence: 99%

Bcl-2/IgH expression in minimal bone marrow infiltration by follicular lymphoma cells

et al. 2011

View full text Add to dashboard Cite

Abstract. The purpose of this study was to investigate the roles of bcl-2 chromosomal translocation and Bcl-2 protein expression in follicular lymphoma (FL) minimal bone marrow (BM) infiltration. We identified the same bcl-2/ IgH fusion gene in paraffin-embedded lymph node (LN) samples and BM samples using immunohistochemistry (IHC), immunocytochemistry (ICC), cytologic morphology and fluorescence in situ hybridization (FISH). The presence of the Bcl-2/IgH fusion gene in the BM samples and paraffin-embedded LN samples from 56 patients with follicular lymphomas was detected using FISH. The Bcl-2 protein levels in BM and paraffin-embedded tissues were quantified using ICC and IHC, respectively. Approximately 78.6% (44/56) of the paraffin-embedded LN tissue sections that underwent FISH analysis had a bcl-2/IgH translocation. The primary lesion was also positive for the bcl-2/IgH fusion gene, as were the BM minimal infiltrates. The bcl-2/ IgH rearrangement occurred in 88.6% (39/44) of the BM specimens. The bcl-2/IgH recombination rate in stage III/IV cancers was significantly different to that observed in stage I/ II cancers (p=0.041). In 59% (23/39) of the cases with t(14;18), Bcl-2 was found to be present as assessed by ICC. Positive Bcl-2 ICC staining and the t(14;18) translocation (as detected using FISH) were positively correlated (p=0.028). We then applied the FISH method to slides that had previously been morphologically evaluated using Wright-Giemsa staining; any slides with at least one abnormal cell were subjected to FISH analysis following staining. The assessment of bcl-2/ IgH translocation status may contribute to the better detection of minimal BM infiltration by FL cells. Utilizing FISH and cytologic morphology techniques allows for earlier and more accessible BM examination.

show abstract

Translocation t(14;18)/IGH‐BCL2 in gastrointestinal follicular lymphoma

Cited by 17 publications

References 39 publications

Follicular lymphoma of the ocular adnexal region: A nation‐based study

Follicular lymphoma of the ocular adnexal region: A nation‐based study

A multicenter survey of enteroscopy for the diagnosis of intestinal follicular lymphoma

Bcl-2/IgH expression in minimal bone marrow infiltration by follicular lymphoma cells

Contact Info

Product

Resources

About