Translocation of heme oxygenase-1 to mitochondria is a novel cytoprotective mechanism against non-steroidal anti-inflammatory drug-induced mitochondrial oxidative stress, apoptosis, and gastric mucosal injury.

Abstract

PAGES 39392 and 39397:The same images of gastric mucosal sections were used to represent the results of different experiments in Fig. 1A and Fig. 7 by mistake. The correct gastric mucosal sections after indomethacin treatment for 12 and 24 h are now shown in Fig. 1A, and the correct gastric mucosal sections at 0, 4, and 48 h after indomethacin treatment, 48 h after indomethacin and zinc protoporphyrin treatment, and 4 h after zinc protoporphyrin treatment are now shown in Fig. 7. These corrections do not change the interpretation of the results or the conclusions of this work.

Sickle Cell Hemoglobin in the Ferryl State Promotes βCys-93 Oxidation and Mitochondrial Dysfunction in Epithelial Lung Cells (E10)

“…We found a significant portion of HO-1 colocalized in the mitochondrial compartment indicating an interesting link between HO-1 overexpression and mitochondrial dysfunction. Some previous studies have shown HO-1 translocation to mitochondria under different stress conditions, and most of these studies postulated a compensatory protective effect of HO-1 by scavenging extra heme load (65,66). It is also possible that HO-1 translocation to mitochondria can lead to localized generation of toxic levels of CO upon degradation of the heme (62).…”

Oxidized Ferric and Ferryl Forms of Hemoglobin Trigger Mitochondrial Dysfunction and Injury in Alveolar Type I Cells

“…A recent study indicated that expression of HO-1 targeted to mitochondria attenuated oxidative stress (43). These observations, taken together, suggest that mitochondrial translocation of HO-1 could serve as a cytoprotective mechanism against possible mitochondrial dysfunction induced by oxidative or metabolic insults (32). However, hemin or LPS-induced mitochondrial accumulation of HO-1 was associated with decreased mitochondrial heme content and reduced expression of heme-sensitive subunit I of complex IV with loss of activity (33).…”

“…Regardless of differences in the rates of heme release from these proteins, confocal microscopy images and immunoblotting of purified mitochondrial fractions confirmed that a portion of expressed HO-1 translocated into the mitochondria. HOs are predominantly localized in the microsomes, but translocation into the mitochondria under certain stressful conditions has been reported (32,34). Mitochondrial translocation of HO-1 might enable detoxification of accumulated heme as a result of oxidation and unfolding of Hb.…”

Redox Signaling and Bioenergetics Influence Lung Cancer Cell Line Sensitivity to the Isoflavone ME-344

“…In addition, Park et al (2011) showed that certain isoflavones can induce HO-1 in primary astrocytes and this can be accompanied by its translocation from the ER to mitochondria (Bindu et al, 2011;Bansal et al, 2013). The first intermediate step of HO-1 catalysis produces Fe 21 , an effective component of the Fenton reaction.…”