Translating Metabolomics to Cardiovascular Biomarkers

Metabolomic Changes in the Rat Retina After Optic Nerve Crush

“…18 The main goal of metabolomic studies is the identification of metabolic markers 19 that may help to discriminate healthy versus pathological conditions, such as infection, 20,21 cancer, [22][23][24] and chronic, 25 cardiovascular, [25][26][27][28] or neurodegenerative diseases. 25,[29][30][31][32][33] Identification of metabolites as biomarkers for neurological diseases has been carried out since the 1990s (reviewed in Ref.…”

Recent Advances and Applications of Metabolomics to Investigate Neurodegenerative Diseases

“…In this sense, "metabolic fingerprinting" approach (Fiehn, 2002) has been demonstrated as a powerful tool in the investigation of AD, ALS, and PD (Tables 1-3) revealing a number of potential biomarkers (Table 4). Similar to other pathological processes such as cancer (Armitage & Barbas, 2014), diabetes (Bain et al, 2009), or cardiovascular diseases (Senn, Hazen, & Tang, 2012), metabolomics is playing an important role in the understanding of pathological processes linked to neurological disorders and is offering unique insights into metabolic alterations as will be discussed later in this chapter. Most of research is based on cerebrospinal fluid (CSF) and blood analysis, although there are a number of studies that have examined other samples such as other tissues or urine (vide infra).…”

The Path to Personalized Cardiovascular Medicine

“…261,[319][320][321] Advanced NMR-and MS-based technologies have been initiated to use in profiling metabolomic changes associated with various CVD ranging from atherosclerosis, AF, and diabetes mellitus to pulmonary hypertension, MI, and HF. 319,320,[322][323][324] Several noninvasive, 1 H-NMR-based metabolomic studies have been applied to assess the severity of CAD; however, they have reached the conclusion that this approach is poor for predicting disease risk compared to standard angiography or clinical measurements of lipids and lipoproteins. [325][326][327] Interestingly, alterations in low and very low density lipoproteins (LDL and VLDL, respectively) appear to be associated with hypertension; this finding deserves further rigorous investigation.…”