LES simulations at Re = 1 × 10 5 and wind tunnel experiments at Re = 5 × 10 5 were conducted to investigate the beneficial effect of an active flow control (AFC) technique on the aerodynamic performance of a simplified truck geometry. The paper involves the investigation of a synthetic jet actuator characterized by periodic blowing and suction that defines a zero net mass flux flow control mechanism. The actuation aims to suppress the flow separation occurring at the A-pillar (front rounded corner) of a truck cabin. The work flow is defined as it follows. First, LES at low Reynolds number are conducted for different disposition of the actuation slots. The results show a beneficial effect when the actuation slots are positioned in streamwise direction compared to spanwise (vertical) direction. Second, based on the previous considerations, wind tunnel experiments are conducted to verify and support the numerical findings. Both numerical solutions and experimental data show the same trend and the superiority of the streamwise slots actuation when compared to traditional vertical slot actuation. In particular, this work shows the weakness of a vertical slot actuation, when its location is not optimized. A small change in its positioning greatly worsen the efficacy of the separation control in terms of drag reduction and separation bubble length. The slot location directly affects the length of the separated flow region which its reduction can vary between 40-70% based on the positioning. Conversely, a streamwise actuation, spanning a larger portion of the curvature of a rounded A-pillar, is not affected by this behaviour and contributes up to 80% of the recirculation bubble reduction measured in the unactuated case. The effect of the location change and the orientation of a zero net mass flux jet slot is therefore investigated and discussed in this work.