Transitory anti-β2-glycoprotein I antibodies in infections

Guérin, Vanessa; Ryman, Anne; Couchouron, Anne

doi:10.1177/096120339900800618

Cited by 5 publications

(1 citation statement)

References 9 publications

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“…14 However, Loisou et al, 15 who studied 12 patients with acute parvovirus B19 infection and without a history of thrombotic events, found a dependence of anticardiolipin binding on the presence of b2-GPI, showing a similarity with their SLE patients. Moreover, Guerin et al 16 studied 41 plasma samples from patients with various acute infections, positive lupus anticoagulant and absence of any thrombotic complications and observed that eight samples were signi®cantly positive for antibodies to b2-GPI. They then suggest that these antibodies may be transitory and asymptomatic during infectious states.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary embolism and transitory anti-b2-GPI antibodies in an adult with chicken pox

Viseux

Darnige

Carmi³

et al. 2000

Lupus

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Anti-beta2-glycoprotein I antibodies are considered as a specific marker for the antiphospholipid syndrome. In contrast to lupus circulating anticoagulant and anticardiolipin (aCL) antibodies, they are usually not found at significant levels in infections. We report a case of pulmonary embolism in an adult with varicella. Transient significant levels of aCL antibodies and of IgM anti-beta2-GPI antibodies were observed. No other prothrombotic factor, including free protein S antigen deficiency, was found. The direct pathogenic role of these transient antibodies on the thrombotic event may then be suspected. They are probably associated with VZV acute infection and are absent two months after varicella.

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Section: Discussionmentioning

confidence: 99%

Pulmonary embolism and transitory anti-b2-GPI antibodies in an adult with chicken pox

Viseux

Darnige

Carmi³

et al. 2000

Lupus

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Changes in platelet activation associated with left ventricular assist system placement

Matsubayashi

Fastenau

McIntyre

2000

The Journal of Heart and Lung Transplantation

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Anticardiolipin, anti- 2-glycoprotein I and antiprothrombin antibodies in black South African patients with infectious disease

Loizou

Singh²,

Wypkema³

et al. 2003

Annals of the Rheumatic Diseases

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Objectives: To investigate IgG, IgM, and IgA, antiphospholipid antibodies (aPL), against cardiolipin (aCL), b 2 -glycoprotein I (anti-b 2 GPI), and prothrombin (anti-PT), in black South African patients with infectious disease. Unlike patients with systemic lupus erythematosus (SLE) and the antiphospholipid syndrome (APS), raised levels of aPL in infectious diseases are not usually associated with thrombotic complications. Patients and methods: Serum samples from 272 patients with a variety of infectious diseases (100 HIV positive, 112 leprosy, 25 syphilis, 25 malaria, and 10 HCV patients) were studied and compared with autoantibody levels in 100 normal controls. All three aPL were measured using commercial enzyme linked immunosorbent assay (ELISA) kits. Results: Raised levels of all thee aPL were found in all patient groups studied: aCL in 7%, anti-b 2 GPI in 6%, and aPT in 43% of 100 HIV patients, in 29%, 89%, and 21% of 112 patients with leprosy, in 8%, 8%, and 28% of 25 patients with syphilis, in 12%, 8%, and 28% of 25 patients with malaria, and in 20%, 30%, and 30% of 10 HCV patients studied, respectively. Conclusions: The prevalence of aCL and anti-b 2 GPI in black South African HIV positive patients, or those with syphilis, malaria, or hepatitis C virus is lower than reported for mixed race or white populations. aPT were the most prevalent aPL detected in these patient groups, except in patients with leprosy, for whom anti-b 2 GPI was the most prevalent, and where the spectrum of aPL was similar to that seen in patients with SLE and APS.

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Transitory anti-β2-glycoprotein I antibodies in infections

Cited by 5 publications

References 9 publications

Pulmonary embolism and transitory anti-b2-GPI antibodies in an adult with chicken pox

Pulmonary embolism and transitory anti-b2-GPI antibodies in an adult with chicken pox

Changes in platelet activation associated with left ventricular assist system placement

Anticardiolipin, anti- 2-glycoprotein I and antiprothrombin antibodies in black South African patients with infectious disease

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