Transitional Cell Carcinoma Involving The Prostate: A Clinicopathological Retrospective Study Of 76 Cases

Ngninkeu, Bertin Njinou; Lorge, Francis; Moulin, Pierre; Jamart, Jacques; Cangh, Paul J. Van

doi:10.1097/00005392-200301000-00036

Cited by 13 publications

(21 citation statements)

References 16 publications

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“…Moreover, Ngninkeu et al. noted similar 5‐year survival for patients with subepithelial vs transmural prostate invasion. Importantly, the series to date have largely been limited by relatively few patients, limited follow‐up, and inconsistent pathological re‐review.…”

Section: Discussionmentioning

confidence: 89%

Urothelial carcinoma involving the prostate: the association of revised tumour stage and coexistent bladder cancer with survival after radical cystectomy

et al. 2014

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Objective• To evaluate survival among patients with urothelial carcinoma (UC) within the prostate in order to assess the impact of depth of tumour invasion as well as the importance of a concurrent bladder tumour. Patients and Methods• We identified 201 patients who underwent radical cystectomy (RC) between 1980 and 2006 and were found to have UC involving the prostate.• All specimens were re-reviewed by a genitourinary pathologist.• Survival was estimated using the Kaplan-Meier method and compared with the log-rank test. Cox hazard regression models tested the association of clinicopathological variables with outcome. Results• In all, 93 patients had pTis disease in the prostate, 43 had pT2 tumours, and 66 patients were pT4a. The median follow-up was 10.5 years.• The 5-year cancer-specific survival for patients with pTis, pT2, and pT4a prostate UC was 73%, 57%, and 21% respectively (P < 0.001).• On multivariable analysis, higher prostate tumour stage (hazard ratio [HR] 2.09; P = 0.01), positive lymph node status (HR 2.09; P = 0.002), and concurrent ≥pT3 bladder cancer (HR 4.16; P < 0.001) were significantly associated with an increased risk of death from UC. Conclusions• Among patients with prostatic UC involvement, depth of tumour invasion was significantly associated with cancer-specific mortality, validating the staging reclassification.• Concurrent locally advanced bladder cancer also negatively impacted survival, suggesting the potential prognostic value of reporting a secondary tumour stage in such cases.

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Section: Discussionmentioning

confidence: 89%

Urothelial carcinoma involving the prostate: the association of revised tumour stage and coexistent bladder cancer with survival after radical cystectomy

et al. 2014

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“…The latter should be distinguished from invasion into prostatic stroma, which usually has a more infiltrative pattern, with irregular rather than smooth bordered urothelial nests, and is associated with a desmoplastic response. Prostatic stromal invasion carries a more ominous staging and prognostic implication [31,32].…”

Section: Prostatementioning

confidence: 99%

Secondary neoplasms of the urinary system and male genital organs

et al. 2009

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BACKGROUND AND AIMS In this review we discuss those secondary tumours involving the urinary system and male genital organs that can pose differential diagnostic difficulties with primary lesions, and highlight morphological and ancillary features that could be helpful in reaching a proper assignment of primary origin. materials AND METHODS Based on MEDLINE database searches all reports of secondary tumours involving the urinary system (kidney and bladder) and male genital organs (prostate, testis and penis) were examined. RESULTS and discussion Involvement by a secondary tumour occurs either as a metastasis or by direct extension. Among non‐genitourinary primary sites, colorectal, pulmonary, skin (melanoma) and breast are the most common contributors. Secondary spread from a genitourinary site primary tumour to another genitourinary organ occurs most frequently between the prostate and urinary bladder, given the intimate topographic proximity of the two. The prognosis is very poor, as the secondary tumour usually occurs in patients with carcinoma in the late stages. Few secondary tumours have distinctive histological and immunohistochemical features, making it difficult to make the appropriate diagnosis. Hence, knowledge of the history and clinical setting are particularly important in these cases. CONCLUSION The urinary system and male genital organs are not common sites for secondary tumours. They often go either undiagnosed or misdiagnosed in the clinical follow‐up of patients with cancer. Accurate diagnosis is essential because of differing therapeutic approaches compared with a primary neoplasm.

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“…In addition, it is not uncommon for urothelial carcinoma of the bladder to extend into the prostatic urethra and ducts . In‐situ involvement of prostatic ducts and acini is considered to be pTis disease, whereas prostatic stromal invasion arising from prostatic ductal involvement of urothelial carcinoma is considered to be pT2 disease.…”

Section: Discussionmentioning

confidence: 99%

GATA3 expression in benign prostate glands with radiation atypia: a diagnostic pitfall

Tian¹,

Dorn

Wei

et al. 2017

Histopathology

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Transitional Cell Carcinoma Involving The Prostate: A Clinicopathological Retrospective Study Of 76 Cases

Cited by 13 publications

References 16 publications

Urothelial carcinoma involving the prostate: the association of revised tumour stage and coexistent bladder cancer with survival after radical cystectomy

Urothelial carcinoma involving the prostate: the association of revised tumour stage and coexistent bladder cancer with survival after radical cystectomy

Secondary neoplasms of the urinary system and male genital organs

GATA3 expression in benign prostate glands with radiation atypia: a diagnostic pitfall

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