Transition of Cationic Dipeptide Nanotubes into Vesicles and Oligonucleotide Delivery

Yan, Xuehai; He, Qiang; Wang, Kewei; Duan, Lixin; Cui, Yue; Li, Junbai

doi:10.1002/ange.200603387

Cited by 127 publications

(126 citation statements)

References 39 publications

(1 reference statement)

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“…Among these, building blocks that are organized from short peptide sequences have become promising tools for biomedical applications. [12,13] Recently, stimuli-responsive morphological transformations of short peptide sequences in water have also been reported. [12,14] We considered a short tripeptide sequence (Lys-Phe-Gly or KFG) that is situated in the juxtamembrane region of the tyrosine kinase nerve growth factor (Trk NGF) receptors, which are involved in neuronal growth and differentiation.…”

mentioning

confidence: 99%

“…[12,13] Recently, stimuli-responsive morphological transformations of short peptide sequences in water have also been reported. [12,14] We considered a short tripeptide sequence (Lys-Phe-Gly or KFG) that is situated in the juxtamembrane region of the tyrosine kinase nerve growth factor (Trk NGF) receptors, which are involved in neuronal growth and differentiation. The absence of the KFG sequence in the receptor polypeptide chain seriously affects the activation of signaling cascades including the Ras superfamily, phosphoinositide 3-kinase, and the Suc1-associated neurotrophic factor target (SNT) protein.…”

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confidence: 99%

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Efficacious Anticancer Drug Delivery Mediated by a pH‐Sensitive Self‐Assembly of a Conserved Tripeptide Derived from Tyrosine Kinase NGF Receptor

et al. 2013

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We present herein a short tripeptide sequence (LysPhe-Gly or KFG) that is situated in the juxtamembrane region of the tyrosine kinase nerve growth factor (Trk NGF) receptors. KFG self-assembles in water and shows a reversible and concentration-dependent switching of nanostructures from nanospheres (vesicles) to nanotubes, as evidenced by dynamic light scattering, transmission electron microscopy, and atomic force microscopy. The morphology change was associated with a transition in the secondary structure. The tripeptide vesicles have inner aqueous compartments and are stable at pH 7.4 but rupture rapidly at pH % 6. The pH-sensitive response of the vesicles was exploited for the delivery of a chemotherapeutic anticancer drug, doxorubicin, which resulted in enhanced cytotoxicity for both drug-sensitive and drug-resistant cells. Efficient intracellular release of the drug was confirmed by fluorescence-activated cell sorting analysis, fluorescence microscopy, and confocal microscopy.

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confidence: 99%

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confidence: 99%

Efficacious Anticancer Drug Delivery Mediated by a pH‐Sensitive Self‐Assembly of a Conserved Tripeptide Derived from Tyrosine Kinase NGF Receptor

et al. 2013

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“…Most importantly, peptide self-assembled nanostructures present a very promising and efficient method for gene drug delivery due to their intrinsic properties and precisely controllable fabrication approaches. Peptide self-assembled nanotubes also could be used for gene drug delivery through the transforming of nanotube structures into nanovesicles in the endocytosis process [128]. Therefore, many conjugations of gene drugs and peptide self-assembled nanostructures have been developed recently for the gene drug delivery systems [129].…”

Section: Gene Drug Deliverymentioning

confidence: 99%

Peptide Self-Assembled Nanostructures for Drug Delivery Applications

Fan

Shen

et al. 2017

Journal of Nanomaterials

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Peptide self-assembled nanostructures are very popular in many biomedical applications. Drug delivery is one of the most promising applications among them. The tremendous advantages for peptide self-assembled nanostructures include good biocompatibility, low cost, tunable bioactivity, high drug loading capacities, chemical diversity, specific targeting, and stimuli responsive drug delivery at disease sites. Peptide self-assembled nanostructures such as nanoparticles, nanotubes, nanofibers, and hydrogels have been investigated by many researchers for drug delivery applications. In this review, the underlying mechanisms for the self-assembled nanostructures based on peptides with different types and structures are introduced and discussed. Peptide self-assembled nanostructures associated promising drug delivery applications such as anticancer drug and gene drug delivery are highlighted. Furthermore, peptide self-assembled nanostructures for targeted and stimuli responsive drug delivery applications are also reviewed and discussed.

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“…However, stabilization may be achieved by adding extra 'outer skin' layers, e.g., α,ω-diorganophosphonate Zr(IV), and the resulting materials may have potential applications in DNA delivery. One work in this direction by Li et al described nanotubes composed of cationic dipeptides that were loaded with ssDNA and then shown to spontaneously disassemble into vesicles and enter into cells (Yan et al 2007). C. R. Martin et al developed 380 nm long nanotubes, which are open at one end and closed at the other, which they refer to as "nano test tubes" (Buyukserin et al 2007).…”

Section: Nanomaterials Scaffolds For Neuroregenerationmentioning

confidence: 99%

Novel Nanomaterials for Clinical Neuroscience

Gilmore

Xiang

Quan

et al. 2008

J Neuroimmune Pharmacol

205

123

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Neurodegenerative disorders including Alzheimer's and Parkinson's diseases, amyotrophic lateral sclerosis, and stroke are rapidly increasing as population ages. The field of nanomedicine is rapidly expanding and promises revolutionary advances to the diagnosis and treatment of devastating human diseases. This paper provides an overview of novel nanomaterials that have potential to improve diagnosis and therapy of neurodegenerative disorders. Examples include liposomes, nanoparticles, polymeric micelles, block ionomer complexes, nanogels, and dendrimers that have been tested clinically or in experimental models for delivery of drugs, genes, and imaging agents. More recently discovered nanotubes and nanofibers are evaluated as promising scaffolds for neuroregeneration. Novel experimental neuroprotective strategies also include nanomaterials, such as fullerenes, which have antioxidant properties to eliminate reactive oxygen species in the brain to mitigate oxidative stress. Novel technologies to enable these materials to cross the blood brain barrier will allow efficient systemic delivery of therapeutic and diagnostic agents to the brain. Furthermore, by combining such nanomaterials with cell-based delivery strategies, the outcomes of neurodegenerative disorders can be greatly improved.

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Transition of Cationic Dipeptide Nanotubes into Vesicles and Oligonucleotide Delivery

Cited by 127 publications

References 39 publications

Efficacious Anticancer Drug Delivery Mediated by a pH‐Sensitive Self‐Assembly of a Conserved Tripeptide Derived from Tyrosine Kinase NGF Receptor

Efficacious Anticancer Drug Delivery Mediated by a pH‐Sensitive Self‐Assembly of a Conserved Tripeptide Derived from Tyrosine Kinase NGF Receptor

Peptide Self-Assembled Nanostructures for Drug Delivery Applications

Novel Nanomaterials for Clinical Neuroscience

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