Peptide Self-Assembled Nanostructures for Drug Delivery Applications

Fan, Taotao; Yu, Xiaoyan; Shen, Bing; Sun, Leming

doi:10.1155/2017/4562474

Cited by 84 publications

(88 citation statements)

References 150 publications

(170 reference statements)

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“…Peptide aggregation or ordered self-assembly presents additional advantages, since it reduces susceptibility to proteolytic degradation, it affects the pharmacokinetics and pharmacodynamics [72,[79][80][81], and it allows the local release of a high peptide concentration at a single site in the membrane [82][83][84]. Finally, aggregates of membrane-active peptides could be even considered for the entrapment of small-molecule drugs inside the hydrophobic core of the particles, for targeted delivery [85][86], leading to the development of new therapeutic tools based on synergistic effects [87].…”

Section: Discussionmentioning

confidence: 99%

Aggregation determines the selectivity of membrane-active anticancer and antimicrobial peptides: The case of killerFLIP

Vaezi¹,

Bortolotti²,

Luca³

et al. 2020

Biochimica et Biophysica Acta (BBA) - Biomembranes

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Host defense peptides selectively kill bacterial and cancer cells (including those that are drugresistant) by perturbing the permeability of their membranes, without being significantly toxic to the host. Coulombic interactions between these cationic and amphipathic peptides and the negatively charged membranes of pathogenic cells contribute to the selective toxicity. However, a positive charge is not sufficient for selectivity, which can be achieved only by a finely tuned balance of electrostatic and hydrophobic driving forces. A common property of amphipathic peptides is the formation of aggregated structures in solution, but the role of this phenomenon in peptide activity and selectivity has received limited attention. Our data on the anticancer peptide killerFLIP demonstrate that aggregation strongly increases peptide selectivity, by reducing the effective peptide hydrophobicity and thus the affinity towards membranes composed of neutral lipids (like the outer layer of healthy eukaryotic cell membranes). Aggregation is therefore a useful tool to modulate the selectivity of membrane active peptides and peptidomimetics.

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Section: Discussionmentioning

confidence: 99%

Aggregation determines the selectivity of membrane-active anticancer and antimicrobial peptides: The case of killerFLIP

Vaezi¹,

Bortolotti²,

Luca³

et al. 2020

Biochimica et Biophysica Acta (BBA) - Biomembranes

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“…40 The high surface-tovolume ratio of nanostructures makes them very suitable to attach lots of targeting molecules that improve the sensitivity of the detecting results. 41,42 The unique properties of nanomaterials or nanostructures confer the nanodiagnostic platforms on an ability of rapid and real-time detection by only using very small volumes of samples from patients. Thus, nanodiagnostic approaches have huge potential to be low-cost, user-friendly, and robust systems.…”

Section: Nanodiagnostics For Infectious Diseasesmentioning

confidence: 99%

Application of nanodiagnostics in point-of-care tests for infectious diseases

Wang¹,

Yu²,

Kong³

et al. 2017

IJN

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Although tremendous efforts have been put into the treatment of infectious diseases to prevent epidemics and mortality, it is still one of the major health care issues that have a profound impact on humankind. Therefore, the development of specific, sensitive, accurate, rapid, low-cost, and easy-to-use diagnostic tools is still in urgent demand. Nanodiagnostics, defined as the application of nanotechnology to medical diagnostics, can offer many unique opportunities for more successful and efficient diagnosis and treatment for infectious diseases. In this review, we provide an overview of the nanodiagnostics for infectious diseases from nanoparticle-based, nanodevice-based, and point-of-care test (POCT) platforms. Most importantly, emphasis focused on the recent trends in the nanotechnology-based POCT system. The current state-of-the-art and most promising point-of-care nanodiagnostic technologies, including miniaturized diagnostic magnetic resonance platform, magnetic barcode assay system, cell phone-based polarized light microscopy platform, cell phone-based dongle platform, and paper-based POCT platform, for infectious diseases were fully examined. The limitations, challenges, and future trends of the nanodiagnostics in POCTs for infectious diseases are also discussed.

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“…A range of self-organized nanostructures with distinct shapes such as fibrous, tubular, rod, particles, and various other shapes are also formed through selfassembly of peptides (Gazit, 2004;Panda and Chauhan, 2014;Prakash Sharma et al, 2015). In the past few years, research on medium sized peptides, small peptides, ultra small peptides, and peptide-conjugates have opened up new avenues for designing and synthesis of peptide-based self-assembled nanostructures for different biological applications (Fan et al, 2017;Guyon et al, 2018;Ni and Zhuo, 2019;Tesauro et al, 2019). These selfassembled peptide-based nanomaterials can be designed with ease to act as new scaffolds to mimic various biomaterials, tissues, etc.…”

Section: Product Namementioning

confidence: 99%

Nanoscale Self-Assembly for Therapeutic Delivery

Yadav

Sharma

Kumar

2020

Front. Bioeng. Biotechnol.

178

136

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Self-assembly is the process of association of individual units of a material into highly arranged/ordered structures/patterns. It imparts unique properties to both inorganic and organic structures, so generated, via non-covalent interactions. Currently, selfassembled nanomaterials are finding a wide variety of applications in the area of nanotechnology, imaging techniques, biosensors, biomedical sciences, etc., due to its simplicity, spontaneity, scalability, versatility, and inexpensiveness. Self-assembly of amphiphiles into nanostructures (micelles, vesicles, and hydrogels) happens due to various physical interactions. Recent advancements in the area of drug delivery have opened up newer avenues to develop novel drug delivery systems (DDSs) and selfassembled nanostructures have shown their tremendous potential to be used as facile and efficient materials for this purpose. The main objective of the projected review is to provide readers a concise and straightforward knowledge of basic concepts of supramolecular self-assembly process and how these highly functionalized and efficient nanomaterials can be useful in biomedical applications. Approaches for the self-assembly have been discussed for the fabrication of nanostructures. Advantages and limitations of these systems along with the parameters that are to be taken into consideration while designing a therapeutic delivery vehicle have also been outlined. In this review, various macro-and small-molecule-based systems have been elaborated. Besides, a section on DNA nanostructures as intelligent materials for future applications is also included.

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Peptide Self-Assembled Nanostructures for Drug Delivery Applications

Cited by 84 publications

References 150 publications

Aggregation determines the selectivity of membrane-active anticancer and antimicrobial peptides: The case of killerFLIP

Aggregation determines the selectivity of membrane-active anticancer and antimicrobial peptides: The case of killerFLIP

Application of nanodiagnostics in point-of-care tests for infectious diseases

Nanoscale Self-Assembly for Therapeutic Delivery

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