Transition metal Kinamycin model as a DNA photocleaver for hypoxic environments: bis(9-diazo-4,5-diazafluorene)copper(II) nitrate†

Metal-assisted light-induced DNA cleavage activity of 2-(methylthio)phenylsalicylaldimine Schiff base copper(II) complexes having planar heterocyclic bases

“…While several types of copper complexes cleaving DNA in the absence or presence of a reducing agent are recently reported [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32], examples of copper complexes showing photoinduced DNA cleavage are generally limited to the porphyrin species [9]. Among non-porphyrinic copper(II) complexes, Zaleski and coworkers [33] have recently reported a binary complex, viz. bis(9-diazo-4,5-diazafluorene)copper(II) nitrate, that shows DNA photocleavage activity.…”

DNA-Cleavage by Fullerene-Based Synzymes

“…A possible reason could be that the amount of 1 used was extremely small compared to the DNA used for the cleaving experiment. Other poly(fullerocyclodextrin)s (2,3) subjected to similar cleaving experiments demonstrated high cleaving efficiency. Further details of the cleaving process using all the polyfullerenes and the characterization of the cleaved DNA samples using various spectral and analytical techniques including laser light scattering and photoluminescence studies will be reported in a full paper.…”

“…[7] The ability of these derivatives to promote 1 O 2 formation using visible region excitation would have significant advantages for in vivo photodynamic therapy applications owing to (i) the typical broad absorption of the fullerene derivatives in the visible region, and (ii) the increased optical penetration depth of the longer wavelength radiations. [2,9] Tabata and Ikada demonstrated for a water-soluble C 60 -poly(ethylene glycol) conjugate that, following its intravenous injection, local irradiation of visible light to the tumor site induced tumor necrosis, in contrast to the conjugate injection alone. That the cleaving process does indeed occur in the presence of visible light was demonstrated by us in a simple experiment between DNA and pristine fullerene.…”

“…It has been reported that it is possible to optically or chemically generate reactive intermediates that perform controlled DNA-cleavage reactions. [2] Fullerenes are electron-deficient photosensitizers, and several groups reported DNA photocleavage mediated by these compounds. [3] Particularly, fullerene derivatives are more attractive because these compounds are preferentially accumulated in tumor-bearing tissue rather than in normal tissue.…”

Characterization, Crystal Structure and Initial DNA Binding Mechanism Research of Multi‐nuclear Homometallic Complexes of 4,5‐Diazafluoren‐9‐one with Copper(II) and Cobalt(II)

“…11 The reactive exocyclic keto function in dafo offers distinct advantages for further derivatization to yield multinuclear metal complexes having interesting catalytic and biological properties. In addition, ruthenium complexes of dafo have been found suitable as building blocks for construction of photoactive supramolecular assemblies.…”