DNA-Cleavage by Fullerene-Based Synzymes

Fullerene Polymers: Synthesis and Properties

“…This fact pointed out that CD not only furnished water solubility to the final polymer but also prevented further branching in the C 60 cage due to its bulkiness. Interestingly, this polymer has been successfully employed as a highly efficient DNA-cleaving agent under visible light conditions . The quantitative DNA-cleaving achieved suggests strong application prospects of water-soluble C 60 -polymers in photodynamic cancer therapy.…”

New Concepts and Applications in the Macromolecular Chemistry of Fullerenes

“…In recent years, several groups have developed different synthetic strategies with the aim to obtain water‐soluble C 60 polymers able to exploit the unique features of fullerenes in a hostile environment such as the aqueous one, in which fullerenes are practically insoluble. The interest of these water soluble C 60 ‐containing polymers lies in their use as efficient DNA‐cleaving agents in the photodynamic cancer therapy (PCT),7 as mimic of the superoxide dismutase,8 as carriers for drug/gene delivery applications,9 and for biological studies in general10 just to name a few potential applications. Among the different strategies used to solubilize fullerenes in water, the covalent linkage of a polysaccharide such as pullulans11 or curdlan sulfates12 to the C 60 cage has been very successful.…”

23 Fullerenes

“…78 Similarly, polymeric fullerocyclodextrins, synthesised by reaction of diamines with [60]fullerene complexed with cyclodextrin, have efficient DNA-cleavage properties in the presence of visible light. 79 Fullerene malonates have been shown to interact with nitric oxide synthase (NOS) distorting its structure, and in doing so, provide a unique mechanism for the isoform-selective inhibition of nNOS. 80 Studies on other water soluble [60]fullerene malonates indicate that this class of molecule is capable of eliminating both superoxide anion and H 2 O 2 and are effective inhibitors of lipid peroxidation.…”