Transition metal coordination compounds of an antiobesity serotoninergic ligand: spectroscopic characterization and adipogenesis activity

Londoño-Lemos, Milton Enrique; Martínez-Bulit, Pablo; López-Sandoval, Horacio; Gracia-Mora, Isabel; Sánchez-Bartéz, Francisco; Castro-Jiménez, Tannya; Duarte-Hernández, Angélica M.; Flores‐Parra, Angelina; Contreras, Rosalinda; Barba-Behrens, Noráh

doi:10.1007/s11243-017-0163-7

Cited by 3 publications

(2 citation statements)

References 36 publications

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“…On the other hand, we recently synthesized and characterized coordination compounds derived from a precursor to serotonin called L-5-Hydroxytryptophan (L-5-HTP). Like leptin, the anorectic serotonergic drugs activate the hypothalamic neurons of the arcuate nucleus (ARC) that express the pro-opiomelanocortin peptide (POMC), so inducing the production of endogenous serotonin would induce to increase the bioavailability of endogenous leptin and thus reversing its endogenous resistance in adipose tissue in obese subjects [13]. As is the case with the Belviq, which recently reported the role of leptin in this serotoninergic drug [14].…”

Section: Bmentioning

confidence: 99%

Untitled

2018

GJPPS

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Obesity affects about 300 million people in the world. More alarming is the fact that there is a strong correlation between the development of childhood obesity and its prevalence in adulthood. The Food and drug administration (FDA), has approved four long-term anti-obesity drugs in adults: Belviq, Contrave, Qsymia and liraglutide in the past two years. Therefore, new pharmacological alternatives are investigated. It is very important to know the intestine-brain axis and hence leptin, which regulates food intake and energy balance, in subjects of normal weight and is a key hormone in the food and body regulation in children and adults.

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Section: Bmentioning

confidence: 99%

Untitled

2018

GJPPS

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“…Several articles have studied the possible application of proteins [ 13 , 14 ], nucleotides [ 15 , 16 , 17 , 18 , 19 ] and simple amino acids [ 20 , 21 ] for the synthesis of fluorescent NCs. These molecules possess several advantageous sulfur- or nitrogen-containing functional groups to bind the soft noble metal ions in the preliminary coordinative interaction [ 22 , 23 , 24 , 25 , 26 , 27 , 28 ]. They also have great pH-dependent redox activity [ 29 , 30 ] to form ultra-small cores having metal atoms with predominantly zero oxidation states.…”

Section: Introductionmentioning

confidence: 99%

Fluorescence Quenching of Tyrosine-Ag Nanoclusters by Metal Ions: Analytical and Physicochemical Assessment

Ungor

Bélteki

Horváth

et al. 2022

IJMS

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A new synthesis method is described for the first time to produce silver nanoclusters (AgNCs) by using the tyrosine (Tyr) amino acid. Several important parameters (e.g., molar ratios, initial pH, reaction time etc.) were optimized to reach the highest yield. The formed Tyr-AgNCs show characteristic blue emission at λem = 410 nm, and two dominant fluorescence lifetime components were deconvoluted (τ1 ~ 3.7 and τ2 ~ 4.9 ns). The NCs contained metallic cores stabilized by dityrosine. For possible application, the interactions with several metal ions from the tap water and wastewater were investigated. Among the studied cations, four different ions (Cu2+, Ni2+, Fe3+, and Rh3+) had a dominant effect on the fluorescence of NCs. Based on the detected quenching processes, the limit of detection of the metal ions was determined. Static quenching (formation of a non-luminescent complex) was observed in all cases by temperature-dependent measurements. The calculated thermodynamic parameters showed that the interactions are spontaneous ranked in the following order of strength: Cu2+ > Fe3+ > Rh3+ > Ni2+. Based on the sign and relations of the standard enthalpy (ΔH°) and entropy changes (ΔS°), the dominant forces were also identified.

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