Transition Metal Complexes with Amino Acids, Peptides and Carbohydrates in Catalytic Asymmetric Synthesis: A Short Review

Abstract

The present review is devoted to the application of transition metal complexes with such ligands as amino acids, peptides and carbohydrates in catalysis. The literature published over the past 20 years is surveyed. Among the distinctive features of these ligands are their versatility, optical activity, stability and availability. Furthermore, depending on the specific synthetic task to be solved, these ligands open up almost infinite opportunity for modification. Largely thanks to their multifaceted reactivity, transition metal complexes with amino acids, peptides and carbohydrates can catalyze most of the known chemical reactions affording optically pure compounds. In this review, the emphasis is placed upon C(sp3)–H activation, cross-coupling and hydrogenation (including traditional hydrogenation in the presence of hydrogen gas and hydrogenation with hydrogen transfer) reactions. The choice is not accidental, since these reactions on the one hand display the catalytic versatility of the above complexes, and on the other hand, they are widely employed in industry.

γ-Amino Alcohols via Energy Transfer Enabled Brook Rearrangement

“…Amino alcoholsone of the most sought-after chemical motifsare equipped with the potent amine (NH 2 ) and hydroxyl (OH) functional groups within their core motif. These entities are known to bind with Lewis acids and transition metals making them flexible building blocks in synthetic, material, as well as in polymer chemistry . As per the 2019 FDA-approved report, out of 24 small-molecule drugs, 13 were found to have either amino acid (AA) or amino alcohol residues, outlining the success of amino alcohols in modern drug design .…”

Synthesis and Biological Activities of Some Metal Complexes of Peptides: A Review

“…The methods for synthesis, heavy metal toxicity, the biosynthesis of metallothioneins and phytochelatins in microalgae, the interaction of metal complexes with peptides, the functions and nature of zinc signals, structure of metal–peptides, relationship of SAR, and biological activity are reported in the following literature reviews: [ 1 , 24 , 25 , 27 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 ]. Some metal complexes can be used as potential therapeutics to treat Alzheimer’s [ 29 , 40 , 41 , 42 ], neurodegenerative disorders, Wilson’s [ 43 ], Parkinson’s disease [ 44 , 45 ] and Menkes disease [ 46 ].…”