Transition metal complexes of s-triazine derivative: new class of anticonvulsant, anti-inflammatory, and neuroprotective agents

Some novel nanostructure Schiff base compounds: Antimicrobial and thermal behaviors

“…Pharmaceutical properties of the metal complexes derived from zinc metal ion and Schiff base ligands have been widely studied, including various areas of medicinal chemistry. There are several metal complexes that are formerly in use for these purposes and this has encouraged further research on new metallodrugs such as metal‐mediated antibiotics and anticancer and antiviral compounds . Schiff base complexes as catalysts play an important role in a variety of chemical and photochemical reactions.…”

“…There are several metal complexes that are formerly in use for these purposes and this has encouraged further research on new metallodrugs such as metal-mediated antibiotics and anticancer and antiviral compounds. [7] Schiff base complexes as catalysts play an important role in a variety of chemical and photochemical reactions. In recent years, some of the chelate complexes have been used as a catalyst for solar energy storage systems.…”

Novel Synthesis of Imidazo‐based and Benzimidazo‐based privileged Templates on s‐Triazine Nucleus through a Phenoxyl Spacer

“…On cooling the reaction mixture, the solid obtained was triturated with water and dried to give 4, yield 4.743 g, 85%; mp 180-182°C. IR (KBr, cm À1 ): 3320 cm À1 (NH), 1585 cm À1 (C═N), 1345 cm À1 (C─O─C), 824 cm À1 (CN, s-triazine); 1 H NMR: Preparation of 6-(4-(1H-imidazol-2-yl)phenoxy)-N 2 ,N 4dicyclopropyl-1,3,5-triazine-2,4-diamine (5). Solution of an imidate ester 4 (0.95 g, 0.0028 mol) and ethylenediamine (1.2 g, 0.02 mol) in ethanol (20 mL) was refluxed for 11 h. The solvent was the distilled off under reduce pressure, and the residue obtained was poured into crushed ice.…”

“…Considering the immensely rich diverse biological properties of s ‐triazine , imidazoles , and benzimidazoles , it was found of paramount interest to incorporate all these biologically active privileged pharmacophores into a single molecular framework by utilizing the reactivity of an active synthon imidate ester (Fig. ).…”

Study of new β-lactams-substituted s-triazine derivatives as potential bioactive agents

“…Besides its wellknown antibiotic activity, this ring system exhibits a wide range of activities, attracting the attention of researchers (Chimento et al, 2013;Jaishree et al, 2012;Bhati and Kumar, 2008;Halve et al, 2007). Moreover, s-triazine derivatives have gained great therapeutic importance in the field of medicinal chemistry since they display a fascinating array of pharmacological properties, such as antimicrobial (Patel et al, 2013b), antifungal (Saleh et al, 2010), antibacterial (Patel et al, 2012), anticancer (Kumar et al, 2013), anti-HIV (Chen et al, 2012), anti-inflammatory (Shanmugakala et al, 2014), antimalarial (Ojha et al, 2011), etc. In our continuous effort toward synthesis of bioactive s-triazine derivatives (Patel et al, 2014b), we report the synthesis of various benzonitrile/nicotinonitrile and azetidin-2-one incorporated s-triazine compounds by applying an efficient Pd-catalyzed C-C Suzuki coupling using catalyst system Pd(OAC) 2 , Xphos (2-dicyclohexylphosphino-2 0 ,4 0 ,6 0 -triisopropylbiphenyl), and K 3 PO 4 as a base in toluene solvent. The antimicrobial activity of synthesized compounds has been carried out against two Gram-positive bacteria, three Gram-negative bacteria, and two fungal species.…”