Transition Metal Complexes of (E)-N’-(4-cyanobenzylidene)nicotinohydrazide): Synthesis, Structural and Anti-Mycobacterial Activity Study

Abstract

A B S T R A C T One step condensation of nicotinic acid hydrazide and 4-cyanobenzaldehyde formed a bidentate acylhydrazone ligand (HL 5 ). The acylhydrazone was characterized by ESI mass spectrometer, CHN analyzer, IR spectrometer, 1 H-NMR, 13 C-NMR and 2D NMR (COSY and HSQC). Thereafter, Mn(II), Mo(V), Fe(II), Cu(II) and Zn(II) complexes of the acylhydrazone ligand were synthesized and characterized based on conductivity measurements, melting point determination, CHN analysis, AAS, magnetic measurement, UV/Visible study, IR spectroscopy, ESR and TGA/DTA studies. The information obtained corroborated results from powder X-ray analysis to arrive at the model structures for the complexes. In vitro antimycobacterial properties of the compounds were evaluated against Mycobacterium tuberculosis H37Rv by using micro-diluted method. The result obtained revealed that HL 5 , Mn(II), Mo(V), Cu(II) and Zn(II) complexes exhibited promising antitubercular activity. Zn(II) complex had the highest MIC value of 0.62 μg MLG 1 , while Fe(II) complex exhibited the lowest MIC value of 1.15 μg MLG 1 . However, the result of cytotoxicity study indicated that acylhydrazone and Zn(II) complex with IC 50 of 2.17 and 1.72 μM, respectively were not toxic compared to isoniazid. Mn(II) complex was however found to be the most toxic.

Synthesis, Characterization and Bio-Potential Activities of Co(II) and Ni(II) Complexes with O and N Donor Mixed Ligands

“…As a consequence, the study of metal complexes of INH has exploded in popularity in the recent decade. Most of the compounds have anti-inflammatory, analgesic, anticonvulsant, antituberculous, anticancer, anti-HIV, and antibacterial effects, according to reports [10]. The biocompatibility of 9-fluorenone has been discovered to be quite interesting.…”

Bis(N′-(3-chlorobenzoyl)isonicotinohydrazide)iron(III) Complex

“…Isoniazid, also known as isonicotinylhydrazide (INH), is an antibiotic used for the treatment of tuberculosis. It has attracted much attention due to its demonstrated biological activity as an antituberculosis [7][8][9][10][11][12][13][14] and anticancer [15][16][17] agent.…”