Bis(N′-(3-chlorobenzoyl)isonicotinohydrazide)iron(III) Complex

Mardianingrum, Richa; Susanti, _; Ruswanto, Ruswanto

doi:10.3390/m1101

Cited by 4 publications

(4 citation statements)

References 21 publications

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“…Figure 4 presents the mass spectrum. The molecular ion peak at m / z 559.31, equal to the complex molecular weight, which was detected in the mass spectrum of Bis-(4-(tert-butyl) -N-(methylcarbamothioyl) benzamide) -Iron (III) (Mardianingrum et al, 2019).…”

Section: Mass Spectrophotometer (Ms)mentioning

confidence: 99%

“…For about 7 hours at 75 o C we reflux it while stirring it using a magnetic stirrer. After that, we evaporate it slowly (Mardianingrum et al, 2019…”

Section: Synthesis Of Metal Complexmentioning

confidence: 99%

“…The 4-(tert-butyl)-N-(methylcarbamothioyl) benzamide is a compound derived from 1-benzoyl-3-methylthiourea (Ruswanto et al, 2018). One of the many advances to drug production is to convert compounds into metal complexes, making their absorption and distribution and their pharmacological activities better (Lin et al, 2008;Mardianingrum et al, 2019;Ruswanto et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and virtual screening of bis-(4-(tert-butyl)-N-(methylcarbamothioyl) benzamide)-Iron (III) complex as an anticancer candidate

et al. 2021

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Thiourea derivatives were much used in drug discovery and drug-making, such as for an anticancer. The formation of drug complexes can increase lipophilicity through chelation formation, and the drug action is significantly upward due to the effective permeability to the center. In another study, the alteration of the compound becomes the complex with metal will grow in its activity so recently we have synthesized the Bis-(4-(Tert-Butyl)-N-(Methylcarbamothioyl) Benzamide)-Iron (III) complex. The synthesis of Fe (III) metal with the 4-(Tert-Butyl)-N-(Methylcarbamothioyl) Benzamide in ethanol by reflux at 75 o C for 7 hours. Hot Stage Microscopy, UV-Visible Spectrophotometry Infrared Spectrophotometry, and Massa Spectrophotometry were used to characterize the complex. This study concerns representing, inferring, and predicting pharmacokinetics and toxicity and molecular docking complexes. The complex weight was 0.29469 g. Its purity has been tested using the melting point determination and has obtained its range was 113 o -115 o C. The Characteristics of Bis-(4-(Tert-Butyl)-N-(Methylcarbamothioyl) Benzamide)-Iron(III) complex have a maximum wavelength of 260 nm and provide absorption of Fe-O vibrations at wavenumbers 478.2 cm -1 and 588 cm -1 , and the m/z complex of spectrophotometry mass was 559.31. The molecular docking process was performed using AutodockTools-1.5.6 software. It showed that Bis-(4-(Tert-Butyl)-N-(Methylcarbamo-thioyl)Benzamide)-Iron(III) complex could interact with ribonucleotide reductase enzyme, and it has better interaction than the 4-(Tert-Butyl)-N-(Methylcarbamothioyl)Benzamide with the binding affinity energy (ΔG)of -8.52 kcal/mole and the constant inhibition (Ki ) of 568.55 nM.

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Section: Mass Spectrophotometer (Ms)mentioning

confidence: 99%

“…For about 7 hours at 75 o C we reflux it while stirring it using a magnetic stirrer. After that, we evaporate it slowly (Mardianingrum et al, 2019…”

Section: Synthesis Of Metal Complexmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Synthesis and virtual screening of bis-(4-(tert-butyl)-N-(methylcarbamothioyl) benzamide)-Iron (III) complex as an anticancer candidate

et al. 2021

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“…Electronic spectrum measurements were performed at 200-800 nm. Uptake was observed at absorbance which corresponds to maximum wavelengths using UV-Vis (Mardianingrum et al, 2020).…”

Section: Uv-vis Spectrophotometrymentioning

confidence: 99%

Synthesis, Characterization and In Silico Study of Fe(III) Complex with N'-(4-Chlorobenzoyl)-Isonicotino-Hydrazide as Anti Tuberculosis Candidate

Ruswanto

Setiawan

Rahayuningsih

et al. 2020

Valensi

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The synthesis of Fe(III) complexes with ligands N'-(4-Chlorobenzoyl)isonicotinohydrazide can be synthesized through mixing metal and ligand dissolved in ethanol by reflux at ± 75oC for 5 hours. The instruments for the characterization of the complex were used UV-Visible and Infrared Spectrophotometry. The aims of the study are: to determine the synthesis method, characterize of the complex, and to study the interaction of the complex with target receptors. The weight of the synthesized compound was obtained by 38.1 mg. The purity of the complex has been tested using the determination of melting point and got a melting point range was 196-198oC. The maximum wavelength of Fe(III)N'-(4-Chlorobenzoyl)isonicotinohydrazid) complex was 261.0 nm and provide absorption of Fe-O vibrations at wavenumbers 530.42 cm-1. The docking process was done using AutodockTools-1.5.6 software which shows that the Fe(III)N'-(4-Chlorobenzoyl) isonicotinohydrazide complex can interact with Enoyl-Acyl Carrier Protein Reductase from Mycobacterium Tuberculosis and it has better interaction than isoniazid or N'-(4-Chlorobenzoyl)isonicotinohydrazide compound with the acquisition of free energy binding (ΔG) -9.80 kcal/mol and inhibition constant (Ki ) 0.06529 μM.

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Recent advances in iron complexes and their interaction with nucleic acids

Parveen

2023

Nucleic Acids

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Bis(N′-(3-chlorobenzoyl)isonicotinohydrazide)iron(III) Complex

Cited by 4 publications

References 21 publications

Synthesis and virtual screening of bis-(4-(tert-butyl)-N-(methylcarbamothioyl) benzamide)-Iron (III) complex as an anticancer candidate

Synthesis and virtual screening of bis-(4-(tert-butyl)-N-(methylcarbamothioyl) benzamide)-Iron (III) complex as an anticancer candidate

Synthesis, Characterization and In Silico Study of Fe(III) Complex with N'-(4-Chlorobenzoyl)-Isonicotino-Hydrazide as Anti Tuberculosis Candidate

Recent advances in iron complexes and their interaction with nucleic acids

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