Transition metal complex/gold nanoparticle hybrid materials

Perevedentseva

et al. 2022

Sci Rep

Hybrid core–shell nanodiamond-gold nanoparticles were synthesized and characterized as a novel multifunctional material with tunable and tailored properties for multifunctional biomedical applications. The combination of nanostructured gold and nanodiamond properties afford new options for optical labeling, imaging, sensing, and drug delivery, as well as targeted treatment. ND@Au core–shell nanoparticles composed of nanodiamond (ND) core doped with Si vacancies (SiV) and Au shell were synthesized and characterized in terms of their biomedical applications. Several bioimaging modalities based on the combination of optical and spectroscopic properties of the hybrid nano-systems are demonstrated in cellular and developing zebrafish larvae models. The ND@Au nanoparticles exhibit isolated ND’s Raman signal of sp3 bonded carbon, one-photon fluorescence of SiV with strong zero-phonon line at 740 nm, two-photon excited fluorescence of nanogold with short fluorescence lifetime and strong absorption of X-ray irradiation render them possible imaging agent for Raman mapping, Fluorescence imaging, two-photon Fluorescence Lifetime Imaging (TP-FLIM) and high-resolution hard-X-ray microscopy in biosystems. Potential combination of the imaging facilities with other theranostic functionalities is discussed.

Section: Introductionmentioning

confidence: 99%

Multimodal bioimaging using nanodiamond and gold hybrid nanoparticles

Perevedentseva

et al. 2022

Sci Rep

“…[40][41][42][43][44] Lanthanum(III), with a f 0 electronic configuration, resembles group(II) metals with remarkable redox stability. [45][46][47] La(III), being a heavy atom, exhibits a profound effect on the photosensitizing ability of photosensitizers and has been previously reported to increase photodynamic efficacy by modulating the singlet oxygen generation via the chelation of La(III) with hypocrellin B (HB) or hypocrellin A (HA). 48,49 Several other La(III) complexes exhibit enhanced photodynamic activity in vitro only in the presence of higher energy light, limiting their applications in PDT.…”

Section: Introductionmentioning

confidence: 99%

La(iii)–curcumin-functionalized gold nanocomposite as a red light-activatable mitochondria-targeting PDT agent

Musib

Ramu

Raza

et al. 2022

Inorg. Chem. Front.

“…Diagnostic and therapeutic agents play critical roles in the combat against this malignant disease. Because of their unique physicochemical properties such as large specific surface area, easy functionalization, and excellent optical, electrical, and magnetic properties, a variety of inorganic nanoparticles (NPs) have been extensively studied for early detection and treatment of cancers since 1996 [ 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ]. For instance, due to their morphology (size, shape, and structure)-dependent localized surface plasmon resonance (LSPR), colloidal gold NPs (AuNPs) have been employed for the development of simple colorimetric sensing systems for sensitive detection of various cancer-related biomarkers and carcinogens [ 2 , 3 , 4 , 9 , 10 , 11 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

The Peptide Functionalized Inorganic Nanoparticles for Cancer-Related Bioanalytical and Biomedical Applications

Jian

Sun

et al. 2021

Molecules

In order to improve their bioapplications, inorganic nanoparticles (NPs) are usually functionalized with specific biomolecules. Peptides with short amino acid sequences have attracted great attention in the NP functionalization since they are easy to be synthesized on a large scale by the automatic synthesizer and can integrate various functionalities including specific biorecognition and therapeutic function into one sequence. Conjugation of peptides with NPs can generate novel theranostic/drug delivery nanosystems with active tumor targeting ability and efficient nanosensing platforms for sensitive detection of various analytes, such as heavy metallic ions and biomarkers. Massive studies demonstrate that applications of the peptide–NP bioconjugates can help to achieve the precise diagnosis and therapy of diseases. In particular, the peptide–NP bioconjugates show tremendous potential for development of effective anti-tumor nanomedicines. This review provides an overview of the effects of properties of peptide functionalized NPs on precise diagnostics and therapy of cancers through summarizing the recent publications on the applications of peptide–NP bioconjugates for biomarkers (antigens and enzymes) and carcinogens (e.g., heavy metallic ions) detection, drug delivery, and imaging-guided therapy. The current challenges and future prospects of the subject are also discussed.