La(iii)–curcumin-functionalized gold nanocomposite as a red light-activatable mitochondria-targeting PDT agent

Abstract

Red light-activable transition metal complexes have recently emerged as the viable alternative for photodynamic/photochemotherapeutic applications. Ideal photosensitizers or photochemotherapeutic agents are still an elusive goal. Here in, we have reported...

A photoactive lysosome targeting RuII complex downregulates stemness genes in oral squamous cell carcinoma

“…Recently, a chemotherapeutic curcumin-acetazolamide-dimethylnitrothiophene compound was reported by Sessler et al, which inhibits the proliferation of CSCs of MDA-MB-231 (triple-negative breast cancer) in the dark. 56 The stable 3,4difluorobenzylidene curcumin (CDF) used by Sessler et al is also found to be active against colon cancer stem cells by Majumdar et al 57 Earlier curcumin-based PDT agents 53,[58][59][60][61][62][63][64] (Fig. 1) have been shown to participate in type-I or type-II photo processes displaying antiproliferative activity against a wide range of cancer cells, and suitable functionalization has led to organelle targeting capabilities.…”

Recent Advances on the Development of Early Transition Metal Complexes for Photo‐Assisted Cytotoxicity Applications

“…Photo-aquation of both the ligand is shown in the complex [Cr(NH 3 ) 5 Br] 2 + , [Cr(NH 3 ) 5 Cl] 2 + . [36,145] The substitution pathway of chromium complexes follows two rules known as Adamson's rules which states that: A. The ligand which lies in the axes of least average field strength is labile and the incoming ligand will approximate the total quantum yield of the octahedral complex.…”

“…Excited states of a molecule have different electronic distribution and geometries undergoing isotropic or anisotropic distortions, bond angle, bond length and have higher rotational and vibrational energy than the ground state. [36][37] In the excited state, the metal-ligand bond length of complexes can be elongated selectively allowing the facile exchange of ligands. The excited state is often a stronger reductant and oxidant than the ground state of a molecule.…”

“…According to the wavelength of irradiation, chromium also showed different proportions of photo induced oxido‐reduction and photo‐aquation. Photo‐aquation of both the ligand is shown in the complex [Cr(NH 3 ) 5 Br] 2+ , [Cr(NH 3 ) 5 Cl] 2+ [36,145] . The substitution pathway of chromium complexes follows two rules known as Adamson's rules which states that:…”

Folate-assisted targeted photocytotoxicity of red-light-activable iron(iii) complex co-functionalized gold nanoconjugates (Fe@FA-AuNPs) against HeLa and triple-negative MDA-MB-231 cancer cells

“…S5 and S6 †). [52][53][54] The folic acid and complex co-functionalized gold nanoparticles (Fe@FA-AuNPs) were prepared by the subsequent addition of a methanolic solution of the complex (0.7 × 10 −3 M, 20 mL) and an aqueous solution of FA-en-LA (0.7 × 10 −3 M, 20 mL) with constant stirring overnight under ambient conditions. A colour change from wine-red of gold nanoparticles (AuNPs) to a dark blue solution indicated the formation of a nanohybrid (Fe@FA-AuNPs).…”