Folate-assisted targeted photocytotoxicity of red-light-activable iron(<scp>iii</scp>) complex co-functionalized gold nanoconjugates (Fe@FA-AuNPs) against HeLa and triple-negative MDA-MB-231 cancer cells

Pal, Maynak; Upadhyay, Aarti; Masarkar, Neha; Bera, Arpan; Mukherjee, Sukhes; Roy, Mithun

doi:10.1039/d3dt03581f

Cited by 3 publications

(1 citation statement)

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“…The typical EPR spectra of DMPO-OH species was detected when (Fe III T-CATL) 3− (50 μM) and GSH (50 μM) were reacted in the presence of 5,5-dimethyl-1-pyrroline N-oxide (DMPO, 0.04 M) in DMF–H 2 O (1 : 1, v/v), exhibiting g -values of 2.05–2.01. 46…”

Section: Resultsmentioning

confidence: 99%

Strategic design and development of a siderophore mimic: pioneering anticancer therapy via ROS generation and ferroptosis

Panwar,

Lye,

Musib

et al. 2024

Dalton Trans.

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Section: Resultsmentioning

confidence: 99%

Strategic design and development of a siderophore mimic: pioneering anticancer therapy via ROS generation and ferroptosis

Panwar,

Lye,

Musib

et al. 2024

Dalton Trans.

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Targeted Chemo‐Phototherapy in Red Light with Novel Doxorubicin and Iron(III) Complex‐Functionalized Gold Nanoconjugate (Dox‐Fe@FA‐AuNPs)

Pal,

Bera,

Masarkar

et al. 2024

Chemistry An Asian Journal

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The anticancer efficacy of doxorubicin, an anthracycline‐based and FDA‐approved chemotherapeutic drug, is significantly hindered by acquired chemoresistance and severe side effects, despite its potent anticancer properties. To overcome these challenges, we developed an innovative therapeutic formulation that integrates targeted chemotherapy and phototherapy within a single platform using gold nanoparticles (AuNPs). This novel nanoconjugate, designated as Dox‐Fe@FA‐AuNPs, is co‐functionalized with folic acid, doxorubicin, and an iron(III)‐phenolate/carboxylate complex, enabling cancer‐specific drug activation. Here, we report the synthesis, characterization, and comprehensive physico‐chemical and biological evaluations of Dox‐Fe@FA‐AuNPs. The nanoconjugate exhibited excellent solubility, stability, and enhanced cellular uptake in folate receptor‐positive cancer cells. The nanoconjugate was potently cytotoxic against HeLa and MDA‐MB‐231 cancer cells (HeLa: 105.5 ± 16.52 µg mL‐1; MDA‐MB‐231: 112.0 ± 12.31 µg mL‐1; MDA‐MB‐231 (3D): 156.31 ± 19.35 µg mL‐1) while less cytotoxic to the folate(‐) cancer cells (MCF‐7, A549 and HepG2). The cytotoxicity was attributed to the pH‐dependent release of doxorubicin, which preferentially occurs in the acidic tumor microenvironment. Additionally, under red light irradiation, the nanoconjugate generated ROS, inducing caspase‐3/7‐dependent apoptosis with a photo‐index (PI) >50, and inhibited cancer cell migration. Our findings underscore the potential of Dox‐Fe@FA‐AuNPs as a highly effective and sustainable platform for targeted chemo‐phototherapy.

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A new iron(iii) complex-functionalized selenium nanowires (Fe@SeNWs) for potential phototherapeutic applications with red light

Bhowmik,

Upadhyay,

Pal

et al. 2024

New J. Chem.

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Folate-assisted targeted photocytotoxicity of red-light-activable iron(iii) complex co-functionalized gold nanoconjugates (Fe@FA-AuNPs) against HeLa and triple-negative MDA-MB-231 cancer cells

Abstract: Photo-redox chemistry resulting from the ligand to metal charge transfer in red-light activale iron(III) complexes could be potent strategic tools for next-generation photochemotherapeutic applications. Here in, we developped iron(III) complex...

Cited by 3 publications

References 94 publications

Strategic design and development of a siderophore mimic: pioneering anticancer therapy via ROS generation and ferroptosis

Strategic design and development of a siderophore mimic: pioneering anticancer therapy via ROS generation and ferroptosis

Targeted Chemo‐Phototherapy in Red Light with Novel Doxorubicin and Iron(III) Complex‐Functionalized Gold Nanoconjugate (Dox‐Fe@FA‐AuNPs)

A new iron(iii) complex-functionalized selenium nanowires (Fe@SeNWs) for potential phototherapeutic applications with red light

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