Transition metal-catalyzed C–H/C–C activation and coupling with 1,3-diyne

Abstract

This review focuses on providing a broad overview of the recent developments in the field of transition metal-catalyzed C-H/C-C bond activation and coupling with 1,3-diyne for assembling alkynylated heterocycles, bis-heterocycles,...

Recent advances in metal directed C–H amidation/amination using sulfonyl azides and phosphoryl azides

“…17,36 To address these issues, the development of catalysts based on first-row transition metals is crucial. The use of non-toxic, cost-effective, and Earth-abundant 3d metal catalysts 10,193 is especially appealing for environmentally friendly transformations. 17,194,195…”

“…17,36 To address these issues, the development of catalysts based on first-row transition metals is crucial. The use of non-toxic, cost-effective, and Earth-abundant 3d metal catalysts 10,193 is especially appealing for environmentally friendly transformations. 17,194,195 Late transition metal complex catalysts have proven effective in catalyzing C-H sulfonamidation and phosphoramidation reactions on various substrates using sulfonyl and phosphoryl azides.…”

Enantioselective Reaction of Diynes and Multiynes for the Synthesis of Axially Chiral Compounds

“…Diynes and multiynes have been wildly exploited in organic synthesis and recognized as highly versatile substrates for the synthesis of cyclic compounds, especially functionalized complicated polycyclic skeletons, which is challenging to construct from other substrates [1] . In the past decades, a numerous of reactions based on diynes and multiynes were developed, such as C−H/C−C activation reaction, [1a,b] hydroelementation reaction, [1c] hexadehydro‐Diels‐Alder reaction, [1d,e] radical cascade cyclization, [1f] [2+2+2] cycloaddition reaction [1g] and others, [1h–j] and a series of synthetically useful carbocycles and heterocycles containing bioactive molecules and natural products were produced efficiently.…”

1,3‐Diynes as Precursors for the Synthesis of Triazene‐ and Diethylaniline‐Bearing Push‐Pull NLOphores

“…[21] The presence of two triple bonds in close proximity makes 1,3-diynes desirable substrates for a variety of chemical transformations, including cycloadditions [22] and metal-catalyzed coupling reactions. [23] The classification of 1,3diynes can be based on the arrangement of their end groups, resulting in two categories: symmetric and unsymmetric. The synthesis of symmetric diynes can be easily accomplished by oxidative coupling of terminal alkynes; Glaser-Eglinton-Hay coupling reactions are the most commonly utilized method for this transformation.…”