Recent advances in metal directed C–H amidation/amination using sulfonyl azides and phosphoryl azides

Abstract

This article reviews the recent advances in the transition metal-catalyzed sulfonamidation and phosphoramidation of a variety of organic compounds. It also covers fundamental concepts and mechanistic aspects, including key intermediates and reaction pathways.

Ruthenium-catalysed direct C–H amidation of 4-aryl-pyrrolo[2,3-d]pyrimidines with acyl/phosphoryl azides

“…15 With the development of aryl azides, sulfonyl azides and phosphoryl azides in direct C-H amination reactions, 16 organic azides in catalytic C-H amidation reactions have been paid more attention by organic chemists. 17 However, the amidation and phosphoramination through organic azides are generally dependent on very expensive transition metals such as iridium or rhodium. Herein, we wish to report an efficient, convenient and highly site-selective C-H amidation and phosphoramidation of 4-aryl pyrrolo[2,3-d]pyrimidines with acyl azides and phosphoryl azides catalysed by [RuCl 2 ( p-cymene)] 2 using AgNTf 2 as an additive in the presence of NaOAc under mild conditions.…”